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Brazilian Journal of Pharmaceutical Sciences

versão On-line ISSN 2175-9790


SILVA, Elthon Gomes Fernandes da et al. Study of sensory-motor and somatic development of the offspring of rats (Wistar) treated with caffeine. Braz. J. Pharm. Sci. [online]. 2009, vol.45, n.4, pp.743-749. ISSN 2175-9790.

The influence of caffeine, administered to rats, on the somatic and sensory-motor development of the offspring was investigated. Female Wistar rats were divided into a control group and a treated group and received drinking water and a 0.1% solution of caffeine orally, respectively. The offspring, also divided into a control group and a treated group, received daily monitoring until the 20th day of life to verify alterations in somatic neural development. The offspring of the treated group had reduced weight on the day of birth and on the 1st, 5th, 15th and 20th days of life; shorter snout-anus length (evaluation done daily); shorter snout-tail length on the day of birth and on the 1st, 5th and 10th days of life, and signs of retardation of somatic and sensory-motor maturation. These results allowed the conclusion that administration of caffeine to rats affects somatic and sensory-motor development of offspring.

Palavras-chave : Caffeine [effects]; Postnatal development; Central nervous system [stimulants].

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