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Brazilian Journal of Pharmaceutical Sciences

versão On-line ISSN 2175-9790

Resumo

PARISE FILHO, Roberto et al. Prodrugs available on the Brazilian pharmaceutical market and their corresponding bioactivation pathways. Braz. J. Pharm. Sci. [online]. 2010, vol.46, n.3, pp.393-420. ISSN 2175-9790.  http://dx.doi.org/10.1590/S1984-82502010000300003.

The aim of this paper was to emphasize the importance of prodrug design to therapy, by examining examples available on the Brazilian pharmaceutical market. The principles of prodrug design are briefly discussed herein. Examples of prodrugs from many important therapeutic classes are shown and their advantages relative to the drugs they are derived from are also discussed. Considering the importance of these therapeutic classes, from both therapy and economic standpoints, prodrug design is a very valuable aspect in the research of new drugs and for the pharmaceutical industry as a whole.

Palavras-chave : Prodrug design; Molecular modification; Drug development.

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