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Brazilian Journal of Pharmaceutical Sciences
versão On-line ISSN 2175-9790
GALDINO, Pablinny Moreira et al. Central activities of hydroalcoholic extract from Lafoensia pacari A. St.-Hil. stem bark. Braz. J. Pharm. Sci. [online]. 2010, vol.46, n.3, pp.455-462. ISSN 2175-9790. http://dx.doi.org/10.1590/S1984-82502010000300008.
Lafoensia pacari A. St.-Hil. can be found from Amapá to Rio Grande do Sul states, and also in Paraguay and Bolivia. It is popularly known as pacari or mangava-brava and is used to promote weight loss, as an anti-thermal or tonic, to treat gastritis, ulcers, scarring, itching, discouragement, and cancer. In the open field tests, the hydroalcoholic extract from L. pacari stem bark (HEP) decreased the number of rearings, number of invaded squares, and increased immobility time compared to control animals. In the pentobarbital-induced sleep time test, HEP decreased latency time to sleep and increased sleeping time. In the rota-rod test, no changes in the studied parameters were observed. In the elevated plus maze, HEP increased the percentage time and percentage entries in the open arms, indicating that this extract exerts an anxiolytic-like activity.
Palavras-chave : Lafoensia pacari A. St.-Hil [pharmacognosy]; Hydroalcoholic extract; Central Nervous System [experimental study]; Anxiety [experimental study].