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Brazilian Journal of Pharmaceutical Sciences

versão On-line ISSN 2175-9790

Resumo

DURAIRAJ, Brindha  e  DORAI, Arthi. Antiplatelet activity of white and pink Nelumbo nucifera Gaertn flowers. Braz. J. Pharm. Sci. [online]. 2010, vol.46, n.3, pp.579-583. ISSN 2175-9790.  http://dx.doi.org/10.1590/S1984-82502010000300023.

Nelumbo nucifera Gaertn (Nelumbonaceae) a plant used in Ayurvedic medicine (common name: lotus), is a perennial, large and rhizomatous aquatic herb most prevalent in South India. Preliminary phytochemical screening of both white and pink Nelumbo nucifera flowers revealed the presence of phytochemical constituents (flavonoids, alkaloids, phenols etc,). Hence, an attempt has been made to screen the effect of Nelumbo nucifera flowers (both types) on platelet aggregation. The antiplatelet activity of hydroethanolic extract of both types of flowers was studied using platelet-rich plasma in different concentrations (100-500µg/ml). Both white and pink Nelumbo nucifera flower extracts showed dose-dependent effective antiplatelet activity with maximum activity at 500µg/ml concentration; prevention of platelet aggregation was 50% of that achieved with standard aspirin. Furthermore, the antiplatelet activity of white flowers was relatively high (p<0.05; ANOVA) compared to pink flowers. In conclusion, these observations suggest that both varieties of Nelumbo nucifera flower extracts exert different levels of inhibitory action on platelets in vitro (secretion and platelet aggregation suppression) due to differences in phytochemical content (alkaloids, flavonoids, phenols, tannins, phytosteroids, glycosides and saponins).

Palavras-chave : Nelumbo nucifera Gaertn [phytochemical constituents]; Nelumbo nucifera Gaertn [pharmacognosy]; Nelumbo nucifera Gaertn [Antiplatelet activity]; Ayurvedic medicine; Natural products; Aspirin.

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