Brazilian Journal of Pharmaceutical Sciences
On-line version ISSN 2175-9790
BURRA, Shashidher; YAMSANI, Madhusudhanrao and VOBALABOINA, Venkateswarlu. The Liquisolid technique: an overview. Braz. J. Pharm. Sci. [online]. 2011, vol.47, n.3, pp.475-482. ISSN 2175-9790. http://dx.doi.org/10.1590/S1984-82502011000300005.
A novel "Powder Solution Technology" involves absorption and adsorption efficiency which makes use of liquid medications, drug suspensions admixed with suitable carriers, coating materials and formulated into free flowing, dry looking, non adherent and compressible powder forms. Based upon a new mathematical model expression, improved flow characteristics and hardness of the formulation has been achieved by changing the proportion of Avicel ® PH 200 and Aerosil ® PH 200 from 50:1 ratio to 5:1 and in which the drug is dispersed in an almost molecularly state. Due to their significantly improved wetting properties a greater drug surface area is exposed to the dissolution media, resulting in an increased dissolution rate and bio availability. By using the Liquisolid technique, sustained drug delivery systems were developed for the water soluble drugs in which hydrophobic non-volatile solvents are used as vehicles.
Keywords : Liquisolid; Solubility; Bioavailability; Flow properties; Load factor; Powder solution technology.