SciELO - Scientific Electronic Library Online

 
vol.47 issue3Design of antiseptic formulations containing extract of Plinia caulifloraFormulation and evaluation of bi-layer floating tablets of ziprasidone HCl and trihexyphenidyl HCl author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Brazilian Journal of Pharmaceutical Sciences

Print version ISSN 1984-8250

Abstract

LONGHI, Joy Ganem; PEREZ, Elisa; LIMA, Jair José de  and  CANDIDO, Lys Mary Bileski. In vitro evaluation of Mucuna pruriens (L.) DC. antioxidant activity. Braz. J. Pharm. Sci. [online]. 2011, vol.47, n.3, pp. 535-544. ISSN 1984-8250.  http://dx.doi.org/10.1590/S1984-82502011000300011.

Mucuna pruriens (L). Dc is a plant of the Fabaceae family, commonly known as velvet bean, itchy bean, chiporro bean, mucuna, among others. This plant has several medicinal properties, including its potential to treat Parkinson's disease (PD). International studies have shown that this plant surpasses the benefits of the substance levodopa in the treatment of PD. Taking into account that nerve cells are highly sensitive to oxidative substances, this study evaluated the antioxidant activity of mucuna and compared it to that of levodopa. The plant seeds' phenolic concentration was quantified by using the Folin-Denis reagent and the antioxidant activity assays were performed by using three different methods: the reduction of the phosphomolybdenium complex, the reduction of radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) and the formation of radical monocation ABTS•+, from the acid [2-2'-azinobis (3-ethylbenzothiazoline-6-sulfonate)]. Results showed that M. pruriens presents high antioxidant capacity, although not superior to isolated levodopa antioxidant capacity. Therefore, further studies should be performed to elucidate the activity of this plant in humans.

Keywords : Mucuna pruriens; Antioxidant; Phenolic compounds.

        · abstract in Portuguese     · text in English     · pdf in English