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Brazilian Journal of Pharmaceutical Sciences

On-line version ISSN 2175-9790


PRICHOA, Franciele Carla; ROMAN, Silvane Souza  and  MANFREDINI, Vanusa. Tissue injuries of wistar rats treated with hydroalcoholic extract of Sonchus oleraceus L.. Braz. J. Pharm. Sci. [online]. 2011, vol.47, n.3, pp.605-613. ISSN 2175-9790.

The use of plant species is emerging as an important alternative in the treatment of injuries. Therefore, the extract of Sonchus oleraceus 10% was employed in the repair of skin lesions. A total of 36 male Wistar rats were subjected to a punch injury and divided into three groups: a negative control, receiving no treatment, a positive control, treated with Dersani, and the experimental group treated with the extract. The injury was assessed macroscopically and microscopically. Morphometric data was collected at the 3rd, 5th and 7th postoperative day, and the experimental group showed greater changes in shrinkage of the lesion compared to control groups. On the 3rd postoperative day, the injury in the experimental group showed less necrotic tissue, lower slough and more granulation tissue in relation to the positive control group. On the 7th and 10th postoperative day, the injury in the experimental group showed lower slough compared to the positive control group. Microscopic analysis of lesions on the 5th postoperative day revealed increased fibroplasia in the experimental group compared to control groups, while on the 14th postoperative day less neovascularization was evident in the experimental group and increased formation of hair follicles in the negative control group. The extract of S. oleraceus provided tissue repair in accordance with normal physiological patterns thus confirming empirical evidence for its use.

Keywords : Sonchus oleraceus [pharmacognosy]; Skin lesions [treatment]; Skin lesions [experimental study]; Wound healing [experimental study]; Medicinal plants.

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