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vol.47 issue3Study of acute toxicity and investigation of the presence of β-N-methylamino-L-alanine in the Gunnera manicata L. a species native to Southern BrazilPhytochemical constituents and preliminary toxicity evaluation of leaves from Rourea induta Planch. (Connaraceae) author indexsubject indexarticles search
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Brazilian Journal of Pharmaceutical Sciences

On-line version ISSN 2175-9790


RAJU, Sama et al. Potential of Pandanus odoratissimus as a CNS depressant in Swiss albino mice. Braz. J. Pharm. Sci. [online]. 2011, vol.47, n.3, pp.629-634. ISSN 2175-9790.

In this study, several neuropharmacological effects of methanolic leaf extract of Pandanus odoratissimus (PO) (family; Pandanaceae) were studied in albino mice using various experimental models. The effect of PO on the CNS was studied by using different neuropharmacological paradigms including spontaneous motor activity, rota-rod performance and potentiation of Pentobarbital sodium sleeping time in albino mice. Preliminary phytochemical evaluation and acute toxicity studies were also carried out where LD50 >2000 mg/kg was considered non-toxic through acute exposure in rats by the oral route. The methanolic leaf extract (50,100 and 200 mg/kg i. p.) produced a reduction in spontaneous motor activity, motor coordination and prolonged Pentobarbital sodium sleeping time. Preliminary qualitative chemical studies indicated the presence of steroids, saponins, terpinoids, glycosides, tannins, flavonoids and phenolics in the extract. These observations suggest that the leaf of Pandanus odoratissimus contains some active principles which possess potential CNS-depressant action

Keywords : Pandanus odoratissimus [pharmacognosy]; CNS-depressant action [experimental study]; Spontaneous motor activity; Rota-rod performance; Sodium pentobarbital [potentiation of sleeping time]; Pandanus odoratissimus [farmacognosia].

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