Brazilian Journal of Pharmaceutical Sciences
Print version ISSN 1984-8250
RAJU, Sama et al. Potential of Pandanus odoratissimus as a CNS depressant in Swiss albino mice. Braz. J. Pharm. Sci. [online]. 2011, vol.47, n.3, pp. 629-634. ISSN 1984-8250. http://dx.doi.org/10.1590/S1984-82502011000300022.
In this study, several neuropharmacological effects of methanolic leaf extract of Pandanus odoratissimus (PO) (family; Pandanaceae) were studied in albino mice using various experimental models. The effect of PO on the CNS was studied by using different neuropharmacological paradigms including spontaneous motor activity, rota-rod performance and potentiation of Pentobarbital sodium sleeping time in albino mice. Preliminary phytochemical evaluation and acute toxicity studies were also carried out where LD50 >2000 mg/kg was considered non-toxic through acute exposure in rats by the oral route. The methanolic leaf extract (50,100 and 200 mg/kg i. p.) produced a reduction in spontaneous motor activity, motor coordination and prolonged Pentobarbital sodium sleeping time. Preliminary qualitative chemical studies indicated the presence of steroids, saponins, terpinoids, glycosides, tannins, flavonoids and phenolics in the extract. These observations suggest that the leaf of Pandanus odoratissimus contains some active principles which possess potential CNS-depressant action
Keywords : Pandanus odoratissimus [pharmacognosy]; CNS-depressant action [experimental study]; Spontaneous motor activity; Rota-rod performance; Sodium pentobarbital [potentiation of sleeping time]; Pandanus odoratissimus [farmacognosia].