SciELO - Scientific Electronic Library Online

vol.48 issue3Myostatin: genetic variants, therapy and gene dopingThe effects of acute administration of the hydroalcoholic extract of rosemary (Rosmarinus officinalis L.) (Lamiaceae) in animal models of memory author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Brazilian Journal of Pharmaceutical Sciences

On-line version ISSN 2175-9790


ISSA, Michele Georges et al. Physicochemical and dissolution profile characterization of pellets containing different binders obtained by the extrusion-spheronization process. Braz. J. Pharm. Sci. [online]. 2012, vol.48, n.3, pp.379-388. ISSN 2175-9790.

With the purpose of evaluating the behavior of different polymers employed as binders in small-diameter pellets for oral administration, we prepared formulations containing paracetamol and one of the following polymers: PVP, PEG 1500, hydroxypropylmethylcellulose and methylcellulose, and we evaluated their different binding properties. The pellets were obtained by the extrusion/spheronization process and were subsequently subjected to fluid bed drying. In order to assess drug delivery, the United States Pharmacopeia (USP) apparatus 3 (Bio-Dis) was employed, in conjunction with the method described by the same pharmacopeia for the dissolution of paracetamol tablets (apparatus 1). The pellets were also evaluated for granulometry, friability, true density and drug content. The results indicate that the different binders used are capable of affecting production in different ways, and some of the physicochemical characteristics of the pellets, as well as the dissolution test, revealed that the formulations acted like immediate-release products. The pellets obtained presented favorable release characteristics for orally disintegrating tablets. USP apparatus 3 seems to be more adequate for discriminating among formulations than the basket method.

Keywords : Binders [evaluation]; Pellets [dissolution profile]; Pellets [physicochemical characteristics]; Extrusion [spheronization process]; Drug delivery [evaluation].

        · abstract in Portuguese     · text in English     · English ( pdf epdf )


Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License