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Brazilian Journal of Pharmaceutical Sciences
On-line version ISSN 2175-9790
SOUZA, Fernanda Santos de; PIROLLI, Mayara Marin; DIEHL, Eliana Elisabeth and SONAGLIO, Diva. Study of the variables which influence the impregnation of globules, compressed tablets and tablet triturates used in homeopathy. Braz. J. Pharm. Sci. [online]. 2012, vol.48, n.3, pp.537-545. ISSN 2175-9790. http://dx.doi.org/10.1590/S1984-82502012000300021.
Globules, compressed tablets and tablet triturates are solid dosage forms used in homeopathy. Divergences can be noted between the preparation techniques described in official compendiums as well as those applied in homeopathic pharmacies. The difficulty associated with standardization of the impregnation of these dosage forms occurs due to the lack of detail provided for the techniques in the literature, leaving it up to each pharmacy to decide on the exact method of preparation. The objective was to optimize the impregnation technique, through investigating the variables that influence the impregnation of globules, compressed tablets and tablet triturates, applying the statistical tool of factorial design. The independent variables were the dosage form, percentage and type of impregnation and drying temperature, and the dependent variables were the mass gain, disintegration time, friability and hardness. For the globules, the greatest mass gain was for 10% impregnation and drying at 20 ºC. For the tablet triturates and compressed tablets the greatest mass gain was for 15% impregnation and there was no difference between the results obtained using simple and triple impregnation or different drying temperatures. The results can contribute to improving the final product quality, besides aiding in the establishment of standardized techniques for the official compendiums.
Keywords : Homeopathic pharmacotechniques; Homeopathic vehicles; Homeopathy [impregnation methods]; Homeopathy [globules]; Homeopathy [tablet triturates]; Homeopathy [compressed tablets].