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Brazilian Journal of Pharmaceutical Sciences

On-line version ISSN 2175-9790


CAMARGO JUNIOR, Flavio Bueno de; GASPAR, Lorena Rigo  and  CAMPOS, Patrícia Maria Berardo Gonçalves Maia. Immediate and long-term effects of polysaccharides-based formulations on human skin. Braz. J. Pharm. Sci. [online]. 2012, vol.48, n.3, pp.547-555. ISSN 2175-9790.

A new trend in cosmetic formulations is the use of biotechnological raw materials as the polysaccharides from Klebsiella pneumoniae, which are supposed to enhance cell renewal, improve skin hydration and micro-relief. Botanical extracts of Myrtus communis leaves contain different sugars, which may provide the same benefits. Thus, the objective of this study was to evaluate through objective and subjective analysis the immediate and long-term effects of cosmetic formulations containing polysaccharides biotechnologically-originated and / or the ones contained in Myrtus communis extracts. Three polysaccharide-based and placebo formulations were applied on the forearm skin of 40 volunteers. Skin hydration, transepidermal water loss (TEWL), viscoelasticity and skin micro-relief measurements were made before and 2 hours after a single application and after 15 and 30 day-periods of daily applications. Answers to a questionnaire about perceptions of formulation cosmetic features constituted the subjective analysis. All polysaccharide-based formulations enhanced skin hydration. Formulations with isolated or combined active substances improved skin barrier function as compared to placebo, in the short and long term studies. Formulations containing Myrtus communis extracts had the highest acceptance. Results suggest that daily use of formulations containing these substances is important for protection of the skin barrier function.

Keywords : Polysaccharides [cosmetic use]; Klebsiella pneumoniae [cosmetic use]; Myrtus communis [cosmetic use]; Cosmetic formulations [evaluation]; Human skin [hydration]; Cosmetology [use of biotechnology]; Biotecnological raw materials [use in cosmetology].

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