Abroma augusta
|
ALO-induced diabetic rabbits |
Aqueous extract of leaves (2 mL/kg, twice daily, PO) for 21 days |
↑beta cell number |
↓FBG, ↓blood urea, ↓serum creatinin |
Mir, Darzi, Mir, 2013 |
Alchornea cordifolia
|
ALO-induced diabetic rabbits |
Ethanolic extract of leaves (250 & 500 mg/kg, PO) for 28
days |
Regeneration of beta cells (at 500 mg/kg) |
- |
Eliakim-Ikechukwu, Obri, 2009 |
Allium sativum
|
STZ-induced diabetic rats |
Aqueous extract (100 mg/kg/day) for 30 days |
↑islets diameter |
↓FBG, ↑serum insulin |
Albajali et al., 2011 |
Allicin (8 & 16 mg/kg, IP) for 30 days |
↓anti-islet cell antibodies; ↓beta cell degeneration |
↑serum insulin, ↓FBG, ↓weight lost, |
Osman et al., 2012 |
A. sativum oil (10 & 20 mg/kg, IP)for 30
days |
Regeneration of pancreatic islets (at 20 mg/kg) |
↓FBG, ↑serum insulin, ↓weight lost |
Alashkham et al., 2013 |
Amaranthus caudatus
|
STZ-induced diabetic rats |
Methanolic extract of leaves (200 & 400 mg/kg,
PO) for 21 days |
Slight regeneration of beta cells (at 400 mg/kg) |
↓FBG, ↓weight lost, ↓serum lipids |
Girija et al., 2011 |
Amaranthus spinosus
|
STZ-induced diabetic rats |
Methanolic extract of leaves (200 & 400 mg/kg, PO)
for 21 days |
Slight regeneration of beta cells (at 400 mg/kg) |
↓FBG, ↓weight lost, ↓serum lipids |
Girija et al., 2011 |
Amaranthus
viridis
|
STZ-induced diabetic rats |
Methanolic extract of leaves (200 & 400 mg/kg,
PO) for 21 days |
Slight regeneration of beta cells (at 400 mg/kg) |
↓FBG, ↓weight lost, ↓serum lipids |
Girija et al., 2011 |
Anacardium occidentale
|
STZ-induced diabetic rats |
A. occidentale extract (300 & 500 mg/kg, twice
daily) for 28 days |
Regeneration of pancreatic beta cells |
↓FBG |
Bassey, Eliakim-Ikechukw, Ihentuge, 2012 |
Anastatica hierochuntica
|
STZ-induced diabetic rats |
Aqueous extract (12.5 mg/rat, PO) for 2 weeks |
↑beta cell number |
↓FBG |
Rahmy, El-Ridi, 2002 |
ALO-induced diabetic rats |
Methanolic extract (100 mg/kg, PO) for 4 weeks |
↑volume density of islets, ↑percentage of beta
cells |
↓FBG, ↓serum lipids, ↓weight lost, ↓liver
enzymes activity, ↑antioxidant enzymes activity |
Shaban, Al-Azzawie, Mohamme, 2011 |
Annona muricata
|
STZ-induced diabetic rats |
Aqueous extract of leaves (100 mg/kg, PO) for 25 days |
↑beta cell number |
↓FBG, ↑serum insulin, ↓oxidative stress indexes in
blood |
Adewole, Caxton-martins, 2006 |
Methanolic extract of leaves (100 mg/kg, IP) for 2 weeks |
↑islets number, ↑beta cell number, ↓inflammatory
infiltration |
↓FBG |
Adeyemi et al., 2008 |
Artanema sesamoides
|
STZ-induced diabetic rats |
Methanolic extract of aerial parts (200 & 400 mg/kg, PO) for 14
days |
↓necrosis of islet cells, ↓degeneration of the islets |
↓FBG, ↓serum lipids, ↓liver enzymes activity,
↓liver and kidney damage, ↑antioxidant defense in liver and
kidney |
Selvan et al., 2008 |
Azadirachta
indica
|
ALO-induced diabetic rats |
Alcoholic extract of leaves (400 mg/kg, twice daily, PO) for 14
days |
Regeneration of new islets |
↓FBG |
Ebong et al., 2006 |
STZ-induced diabetic rats |
Ethanolic extract of leaves (500 mg/kg, twice daily, PO) for 50
days |
↑beta cell density; ↓pancreatic lipid hydroperoxide
levels |
↓FBG |
Akinola, Caxton-Martins, Dini, 2010 |
Bauhinia variegata
|
ALO-induced diabetic rats |
Ethanol extract of bark (500 mg/kg, PO) for 15 days |
Restored the cellular size and number of islets towards normal |
↓FBG, ↓serum lipids |
Koti et al., 2009 |
Berberine |
ALO-induced diabetic rats |
berberine (100 & 200 mg/kg, PO) for 21 days |
Moderate expansion of islets, ↓damage scores |
↓FBG, ↓serum lipids, ↓oxidative stress in the
heart |
Tang et al., 2006 |
STZ- and high carbohydrate/fat diet-induced diabetic rats |
berberine (75-300 mg/kg, PO) for 16 weeks |
↑beta cells number, ↑insulin expression, ↓oxidative
stress indexes |
↑serum insulin |
Zhou et al., 2009 |
Cassia alata
|
STZ-induced diabetic rats |
Ethanolic extract of leaves (500 mg/kg, twice daily, PO) for
28 days |
Regeneration of beta cells |
↓FBG |
Eliakim-Ikechukwu et al., 2013 |
Cassia occidentalis
|
ALO-induced diabetic rats |
Aqueous extract of whole plant (200 mg/kg, PO) for 21
days |
Partial restoration of cellular population and size of islet cells |
↓FBG, ↓serum lipids |
Verma et al., 2010 |
Clitoria ternatea
|
STZ-induced diabetic rats |
Ethanolic extract of aerial parts (200 mg/kg, PO)
for 21 days |
↓necrosis of islets, ↓fibrosis of islets, improvement in
beta cell granulation |
↓FBG, ↓weight lost, ↓serum lipids |
Verma, Itankar, Arora, 2013 |
Curcumin
|
STZ-induced diabetic mice |
Curcumin (200 mg/kg, IP) for 12 weeks |
↓lymphocytes infiltration in the islets, ↑islets
number |
↓FBG, ↓weight loss |
Chanpoo, Petchpiboonthai, 2010 |
STZ-induced diabetic rats |
Curcumin derivative (150 mg/kg, PO) for 40 days |
↑islet cells number, ↑insulin positive cells |
↓FBG, ↑serum insulin, ↑C-peptide |
Abdel Aziz et al., 2013 |
Crocus sativus
|
ALO-induced diabetic rats |
Ethanolic extract of stigmas (40 mg/kg, IP) for 14 days |
↑beta cell number, ↑immunoreactivity of insulin in beta
cells |
↓FBG, ↑serum insulin |
Mohajeri, Mousavi, Doustar, 2009 |
Ethanolic extract (200 - 600 mg/kg, PO) for 4 weeks |
The animals had normal histological structure (at 600
mg/kg) |
↓FBG, ↓serum lipids, ↓weight lost, ↑serum
insulin, improved kidney and liver function |
Elgazar et al., 2013 |
Elephantopus scaber
|
ALO-induced diabetic rats |
Aqueous extract of root and leaves (0.3 g/kg, PO) for
12 weeks |
↑beta cell number per islet |
↓FBG, ↓serum lipids, ↓serum urea,
↓creatinine |
Daisy, Rayan, Rajathi, 2007 |
Epicatechin |
ALO-induced diabetic rats |
Epicatechin (30 mg/kg, twice daily, IP) for 4-5 days |
↑beta cell number per islet |
↓FBG, ↑serum insulin |
Chakravarthy, Gupta, Gode, 1982 |
Gymnema sylvestre
|
STZ-induced diabetic rats |
Water soluble extract of leaves |
↑islets number, ↑beta cell number |
↓FBG, ↑serum insulin |
Shanmugasundaram et al., 1990 |
Standardized extract of leaves (200 & 400 mg/kg, PO)
for 40 days |
↓congestion, ↑normal beta cells |
↓FBG, ↓HbA1c, ↓serum lipids, ↓weight lost,
↑serum insulin, ↑glycogen content in liver |
Aralelimath, Bhise, 2012 |
ALO-induced diabetic rats |
Methanol extract of leaves and callus for 45 days |
↑beta cell regeneration |
↑body weight, ↑glycogen content in liver |
Ahmed, Rao, Rao, 2010 |
Juglans regia
|
ALO-induced diabetic rats |
Diet supplemented with 60 g/kg of leaves for 15 days |
↑islets density, ↑percent of beta cells, ↑islets
size |
↓FBG |
Jelodar, Mohsen, Shahram, 2007 |
Ethanolic extract of leaf (200 mg/kg) |
Enlargement of islets size |
↑serum insulin, ↓HbA1c |
Asgary et al., 2008 |
STZ-induced diabetic rats |
Methanolic extract of leaves or peel (200 mg/kg, PO)
for 4 weeks |
↑beta cell number |
↓FBG, ↑serum insulin, ↓HbA1c |
Javidanpour et al., 2012 |
Aqueous extract of shell septum (200 - 800 mg/kg, PO) f or 4
weeks |
No effect |
↓FBG |
Dehghani, Mashhoody, Panjehshahin, 2012 |
Leucaena leucocephala
|
STZ-induced diabetic rats |
Extract of seed (0.25 - 1 g/kg, PO) for 14 days |
↑beta cell number per islets, ↑islets diameter |
↓FBG, ↓serum lipids |
Darmono Syamsudin, Simanjuntak, 2006 |
Mangiferin |
Partial pancreatectomy-induced diabetic mice |
Mangiferin (30 & 90 mg/kg, IP) for 14 days |
↑beta cell hyperplasia, ↑beta cell proliferation,
↓beta cell apoptosis |
↓FBG, ↑serum insulin, ↑glucose tolerance |
Wang et al., 2014 |
Momordica charantia
|
STZ-induced diabetic rats |
Fruit juice (10 mL/kg, PO) for 10 weeks |
↑beta cell number |
↑serum insulin |
Ahmed et al., 1998 |
ALO-induced diabetic rats |
Acetone extract of fruit (250-750 mg/kg, PO) for 30 days |
Recovery of beta cells of the islets of Langerhans |
Hepatoprotection |
Singh, Gupta, 2007b |
Alcoholic extract of fruit (250-750 mg/kg, PO) for 30 days |
Recovery of beta cells of the islets of Langerhans |
↓FBG |
Singh et al., 2008 |
Neonatal STZ-induced type-2 diabetic rats |
Aqueous extract of fruit (20 mg/kg, PO) for 4 weeks |
↑beta cell number per islet |
↓FBG, ↑ serum insulin |
Abdollahi et al., 2011 |
Momordica charantia
|
Neonatal STZ-induced type-2 diabetic rats |
Ethanolic extract of fruit (400 mg/kg, PO) for 4 weeks |
↑islet size, ↑total beta cell area, ↑beta cell
number |
↓FBG, ↑serum insulin |
Hafizur, Kabir, Chishti, 2011 |
Morus alba
|
STZ-induced diabetic rats |
Ethanolic extract of leaves (400 & 600 mg/kg, PO)
for 35 days |
↑islets diameter, ↑beta cell number |
↓FBG |
Mohammadi, Prakash, 2008 |
Nigella sativa & Thymoquinone |
STZ-induced diabetic rats |
Volatile oil (0.2 mL/kg, IP) for 30 days |
Regeneration/proliferation of pancreatic β-cells |
↓FBG, ↑serum insulin |
Kanter et al., 2003 |
Volatile oil (0.2 mL/kg, IP) for 30 days |
Preserving beta cell numbers, ↓oxidative stress |
↓oxidative stress parameters in blood |
Kanter et al., 2004 |
Thymoquinone (50 mg/kg, PO) for 4 weeks |
↓islet degeneration and necrosis |
↓FBG, ↑serum insulin |
Kanter, 2009 |
N. sativa oil (0.2 mL/kg) for 30
days |
↑islets diameter |
↓FBG, ↑serum insulin |
Albajali et al., 2011 |
Aqueous extract (2 mL/kg, IP), oil (0.2 mL/kg, IP) or thymoquinone
(3 mg/kg, IP) for 30 days |
↓oxidative stress indexes, partial regeneration of the islets and
beta cells |
↓FBG, ↑serum insulin |
Abdelmeguid et al., 2010 |
STZ + nicotinamide-induced diabetic rats |
Thymoquinone (80 mg/kg) for 45 days |
Preservation of islet cells against beta cell damage |
↓oxidative stress in liver and kidney |
Sankaranarayanan, Pari, 2011 |
Prangos
ferulacea
|
STZ-induced diabetic rats |
Hydroalcoholic extract of leaves, stem and root (100 mg/kg,
PO) for one month |
↓lymphocytes infiltration, ↓necrotic cells, regeneration of
islets |
↓FBG, ↓weight loss, ↓HbA1c |
Soltani Band et al., 2011 |
Pterocarpus marsupium
|
ALO-induced diabetic rats |
A flavonoid fraction extracted from the bark |
Regeneration of beta cells |
↓FBG |
Chakravarthy et al., 1980 |
Sansevieria trifasciata
|
ALO-induced diabetic rats |
Decoction of leaves (100 - 200 mg/kg, PO) for 30 days |
↑granule density in beta cells of islets |
↓FBG |
Qomariyah, Sarto, Pratiwi, 2012 |
Solanum nigrum
|
ALO-induced diabetic rats |
Aqueous extract of leaves (400 mg/kg) for 21 days |
Partial restoration of islets population and hyperplasia of islet
cells |
↓FBG |
Maniyar, Umamageswari, Karthikeyan, 2012 |
Syzygium cumini
|
ALO-induced diabetic rats |
Alcoholic extract of seeds (250-750 mg/kg, PO) for 30
days |
Hypertrophy of certain islets, ↑granule density in beta
cells |
↓FBG, ↑body weight, |
Singh, Gupta, 2007a |
Teucrium
polium
|
STZ-induced diabetic rats |
Hydroalcoholic extract (equivalent to 0.5 g plant/kg, PO) for 6
weeks |
↑islets number, ↑beta cell number, ↓lymphocytes and
macrophages number |
↓FBG, ↓bilirubin, ↓glutamate oxaloacetate
transferase, ↓glutamate pyruvate transferase, ↑serum
insulin |
Yazdanparast, Esmaeili, Ashrafi, 2005 |
Tinospora cordifolia
|
STZ-induced diabetic rats |
Methanolic extract of stem (250 mg/kg, PO) for 100 days |
Regeneration of beta cells |
↓FBG, ↓HbA1c, ↑serum insulin, ↑C-peptide |
Rajalakshmi et al., 2009 |
Trigonella foenum- graceum
|
Neonatal STZ-induced type-2 diabetic rats |
Hydroalcoholic extract of seeds (100 mg/kg, PO) for
28 days |
↑beta cell number, ↑islet size |
↓FBG, ↓weight lost, ↓HbA1c, ↑serum insulin |
Kulkarni et al., 2012 |
Thunbergia laurifolia
|
ALO-induced diabetic rats |
Extract of leaves (60 mg/rat, PO) for 15 days |
Recovery of some beta cells |
↓FBG |
Aritajat, Wuteerapol, Saenphet, 2004 |
Vernonia amygdalina
|
ALO-induced diabetic rats |
Pre-treated with aqueous extract (250 mg/kg, PO) for
21 days |
Moderate regeneration of islets |
↓FBG |
Sunday et al., 2012 |
Ethanolic extract of leaves (400 mg/kg, PO) for 14 days |
Regeneration of new islet cells |
↓FBG, ↓serum alpha-amylase activity |
Atangwho et al., 2007 |
Vinca rosea
|
|
Methanolic extract of leaves (300 & 500 mg/kg,
PO) for 14 days |
Partial restoration of normal cellular population and enlarged size of
beta cells |
↓FBG, ↑glucose tolerance, ↓serum lipids,
↓weight lost, ↓creatinine, ↓urea, ↓alkalin
phosphatase |
Ahmed et al., 2010 |
Urtica dioica
|
STZ-induced diabetic rats |
Hydroalcoholic extract (100 mg/kg, IP) for 5 days before induction of
diabetes |
↑beta cells number |
↓FBG |
Golalipour et al., 2010 |
Urtica pilulifera
|
STZ-induced diabetic rats |
Lectin isolated from seeds (100 mg/kg, IP) for 4 weeks |
↓cellular damage in pancreas |
↓FBG, ↓weight lost |
Kavalali et al., 2003 |