Testosterone (Log P = 3.47) |
Rat skin |
Saline + 40% Polyethylene glycol 400/37 °C/NIc
|
Keshary-Chien |
26 h |
Kim et al., 2001KIM, M.K.; ZHAO, H.; LEE, C.H.; KIM, D.D. Formulation of a reservoir-type testosterone transdermal delivery system. Int. J. Pharm., v.219, n.1-2, p.51-59, 2001.
|
Oxybutynin (Log P = 5.19) |
Rabbit ear skin |
0.9% Saline/37°C/NIc
|
Franz |
8 h |
Nicoli et al., 2006NICOLI, S.; PENNA, E.; PADULA, C.; COLOMBO, P.; SANTI, P. New transdermal bioadhesive film containing oxybutynin: In vitro permeation across rabbit ear skin. Int. J. Pharm., v.325, n.1-2, p.2-7, 2006.
|
Valsartan (Log P = 4.75) |
Rat and hairless mice skin, skin of Yucatan micropig (dermatomated) |
PBSb pH 7.4/37°C/ 600 rpm |
Vertical |
8 h for drug suspensions, and 48 h for transdermal patches |
Nishida et al., 2010NISHIDA, N.; TANIYAMA, K.; SAWABE, T.; MANOME, Y. Development and evaluation of a monolithic drug-in-adhesive patch for valsartan. Int. J. Pharm., v.402, n.1-2, p.103-109, 2010.
|
Ondansetron (Log P = 2.07) |
Hairless mice skin |
PBSb pH 7.4/37°C/NIc
|
Franz |
NIc
|
Obata et al., 2010OBATA, Y.; ASHITAKA, Y.; KIKUCHI, S.; ISOWA, K.; TAKAYAMA, K.A Statistical approach to the development of a transdermal delivery system for ondansetron. Int. J. Pharm., v.399, n.1-2, p.87-93, 2010.
|
Nicotine (Log P = 0.72) |
Human skin (200 µm, dermatomated) |
Saline 0.9%/37°C/NIc
|
Diffusion cell modified with silver-silver chloride electrode |
NIb
|
Wu et al., 2010WU, J.; PAUDEL, K.S.; STRASINGER, C.; HAMMELL, D.; STINCHCOMB, A.L.; HINDS, B.J. Programmable transdermal drug delivery of nicotine using carbon nanotube membranes. Proc. Natl. Acad. Sci. U. S. A., v.107, n.26, p.11698-11702, 2010.
|
Theophylline (Log P = -0.17) and hydrocortisone (Log P = 1.43) |
Porcine ear skin |
PBSb pH 7.4 + 0.03% of sodium azide (preservative)/32°C/NIc
|
Franz |
48 h (theophylline) and 52 h (hydrocortisone) |
Novotný et al., 2011NOVOTNÝ, M.; KLIMENTOVÁ, J.; JANŮŠOVÁ, B.; PALÁT, K.; HRABÁLEK, A.; VÁVROVÁ, K. Ammonium carbamates as highly active transdermal permeation enhancers with a dual mechanism of action. J. Control. Release, v.150, n.2, p.164-170, 2011.
|
Diclofenac sodium (Log P = 4.06) |
Human skin (only epidermis) |
PBSb pH 7.4 + 2.5% hydroxypropyl-β-cyclodextrin/NIb/400 rpm |
Franz |
NIb
|
Snorradóttir et al., 2011SNORRADÓTTIR, B.S.; GUDNASON, P.I.; THORSTEINSSON, F.; MÁSSON, M. Experimental design for optimizing drug release from silicone elastomer matrix and investigation of transdermal drug delivery. Eur. J. Pharm. Sci., v.42, n.5, p.559-567, 2011.
|
Donepezil (Log P = 4.71) |
Hairless mice and human skin |
PBSb pH 7.4/32°C/ 600 rpm |
Keshary-Chien |
12 h |
Choi et al., 2012CHOI, J.; CHOI, M.-K.; CHONG, S.; CHUNG, S.-J.; SHIM, C.-K.; KIM, D.-D. Effect of fatty acids on the transdermal delivery of donepezil: In vitro and in vivo evaluation. Int. J. Pharm., v.422, n.1-2, p.83-90, 2012.
|
Timolol (Log P = 0.68) |
Guinea pig skin and human skin |
Phosphate buffer pH 7.4/37 °C/600 rpm |
Keshary-Chien modified with silver-silver chloride electrode |
7h |
Patni et al., 2012PATNI, M.; PURANIK, P.; SONAWANE, A.; PANZADE, P. Transdermal iontophoretic delivery of timolol maleate. Braz. J. Pharm. Sci., v.48, n.4, p.819-827, 2012.
|
Donepezil (Log P = 4.71) |
Hairless mice skin |
Buffer pH 6.0/37°C/NIc
|
Flow-through cell |
24 h |
Subedi et al., 2012SUBEDI, R.K.; RYOO, J.P.; MOON, C.; CHUN, M.K.; CHOI, H.K. Formulation and in vitro evaluation of transdermal drug delivery system for donepezil. J. Pharm. Investig., v.42, n.1, p.1-7, 2012.
|
Theophylline (Log P = -0.17) and hydrocortisone (Log P = 1.43) |
Porcine ear skin |
PBSb pH 7.4 + 0.03% of sodium azide (preservative)/32°C/NIc
|
Franz |
48 h (theophylline) and 52 h (hydrocortisone) |
Janůšová et al., 2013JANŮŠOVÁ, B.; ŠKOLOVÁ, B.; TÜKÖROVÁ, K.; WOJNAROVÁ, L.; ŠIMŮNEK, T.; MLADĚNKA, P.; FILIPSKÝ, T.; ŘÍHA, M.; ROH, J.; PALÁT, K.; HRABÁLEK, A.; VÁVROVÁ, K. Amino acid derivatives as transdermal permeation enhancers. J. Control. Release, v.165, n.2, p.91-100, 2013.
|
Fluoxetine (Log P = 4.09) |
Hairless mice, rat and human skin |
PBSb pH 7.4 + 6% of Brij98d/37 °C/600 rpm |
Keshary-Chien |
12 h |
Jung et al., 2013JUNG, E.; KANG, Y.P.; YOON, I.S.; KIM, J.S.; KWON, S.W.; CHUNG, S.J.; SHIM, C.K.; KIM, D.D. Effect of permeation enhancers on transdermal delivery of fluoxetine: In vitro and in vivo evaluation. Int. J. Pharm., v.456, n.2, p.362-369, 2013.
|
Nicotine (Log P = 0.72) |
Porcine ear skin |
PBSb pH 7.4/32°C/ 600 rpm |
Vertical |
48 h |
Ruela et al., 2013RUELA, A.L.M.; FIGUEIREDO, E.C.; PERISSINATO, A.G.; LIMA, A.C.Z.; PEREIRA, G.R. In vitro evaluation of transdermal nicotine delivery systems commercially available in Brazil. Braz. J. Pharm. Sci., v.49, n.3, p.579-588, 2013. ; Ruela, Figueiredo, Pereira, 2014 |
Isosorbide dinitrate (Log P = -0.90) |
Hairless rat skin |
Saline + Polyethyleneglycol 400/37 °C/200 rpm |
Franz |
24 h |
Zhan et al., 2015ZHAN, X.; MAO, Z.; CHEN, S.; CHEN, S.; WANG, L. Formulation and evaluation of transdermal drug-delivery system of isosorbide dinitrate. Braz. J. Pharm. Sci., v.51, n.2, p.373-382, 2015.
|