SciELO - Scientific Electronic Library Online

vol.54 issue3Comparative evaluation of pancreatic histopathology of rats treated with olanzapine, risperidone and streptozocinStability and in vivo efficiency of natural cosmetic emulsion systems with the addition of vegetable oils author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand




Related links


Brazilian Journal of Pharmaceutical Sciences

On-line version ISSN 2175-9790


CIFTCI, Osman; DUMAN, Ahmet Sefa; TURKMEN, Neşe Basak  and  TASLıDERE, Aslı. Beta-glucan prevents toxic effects of 2,3,7,8-TCDD in terms of oxidative and histopathological damage in heart tissue of rats. Braz. J. Pharm. Sci. [online]. 2018, vol.54, n.3, e17674.  Epub Nov 29, 2018. ISSN 2175-9790.

2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) is a widespread environmental contaminant which causes severe toxic effects. Despite there is some suggestion concerning with TCDD induced cardiotoxicity such as formation of free radicals, the main mechanism has not been entirely explained. Beta-glucan is known as strong antioxidant matter and can scavenge free radicals. Therefore this study aimed to investigate the protective effects of beta-glucan against TCDD induced cardiotoxicity in rats. In this study, 2-3 months of age and 190-250 g in weight 32 rats were randomly divided into four equal groups (n=8 for each group). Group 1 was control; Group 2 was TCDD group (2 µg/kg/week); group 3 was the beta-glucan group(50 mg/kg/day), and group 4 was TCDD and beta-glucan treatment group. The heart samples were taken from rats after 21 days treatment. The results were shown that Despite TCDD exposure visibly caused to increase (p ≤ 0.001) in TBARS levels, It caused a visible decline in the levels of GSH, CAT, GSH-Px, and SOD. However Beta glucan significantly increased GSH, CAT, GSH-Px, SOD levels and decreased generation of TBARS. Additionally, our histopathological observations were in agreement with the biochemical results. In conclusion, Beta-glucan treatment exhibited protective activity on TCDD induced cardiotoxicity.

Keywords : Beta-glucan/protective effects; 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD); Cardiotoxicity; Rats.

        · text in English     · English ( pdf )