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Epidemiologia e Serviços de Saúde

Print version ISSN 1679-4974On-line version ISSN 2237-9622


SILVA, Suelem Santos et al. Analysis of adverse events following immunization in Minas Gerais, Brazil, 2011: a cross-sectional study. Epidemiol. Serv. Saúde [online]. 2016, vol.25, n.1, pp.45-54. ISSN 1679-4974.


to analyze the main adverse events occurring following immunization in Minas Gerais State, Brazil, in 2011.


this is a cross-sectional study using secondary data from the Brazilian Information System on Adverse Events Following Immunization.


1,449 adverse events were found; more than half occurred in children under one year of age (56.1%; OR=1.39; 95%CI: 1.08;1.78); the highest rates per 100,000 doses administered were found in the Southern Triangle (36.3), Northwest (25.7) and Southern (22.7) areas of the state; tetravalent vaccine had the highest reactogenicity (46.1%) and hypotonic-hyporesponsive episode was the most frequent event (15.9%); events were significantly associated with inactivated vaccines (OR=4.08; 95%CI: 3.51;4.75); most of the reported events were closed as 'undefined' (58.9%).


events were found in all regions of Minas Gerais state and were most frequent following administration of inactivated vaccines and among children under one year of age.

Keywords : Vaccination/Adverse Events; Health Information Systems; Health Evaluation.

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