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Audiology - Communication Research

versão On-line ISSN 2317-6431


CASTRO, Aline Rejane Rosa de; BARRETO, Simone Rosa; MANCINI, Patrícia Cotta  e  RESENDE, Luciana Macedo de. Middle Latency Responses (MLR) in Brazilian children and adolescents: systematic review. Audiol., Commun. Res. [online]. 2015, vol.20, n.4, pp.384-391. ISSN 2317-6431.


Systematically review the scientific literature on Middle Latency Response (MLR) in Brazilian children and adolescents.

Research strategy:

We searched articles published since 2009 in Portuguese, English or Spanish at MEDLINE, SciELO, BIREME and LILACS electronic basis. Selected articles involved the use of MLR in children and / or Brazilian adolescents. After screening process, articles were analyzed according to “Strengthening the Reporting of Observational Studies in Epidemiology” (STROBE) initiative.

Selection criteria:

Repeated articles (due to database repetition) and case reports were excluded.


From 1315 identified articles, eight were selected for the review. It was predominantly observed: cross-sectional studies (75%); click stimulation (100%), with rate up to 11/s (100%) and 70 dBHL intensity (88%); filtering high-pass 10 Hz (50%) and low-pass 200 Hz (75%); electrode array with actives placed at C3/C4, references at A1/A2 and neutral at Fpz (88%); Na-Pa amplitude as main measure of comparison and normality; and the use of ANOVA test (63%) for statistical analyses. The average latency of Pa wave and Na-Pa amplitude in normal-hearing children and adolescents of the studies was 32 milliseconds and 1.57 microvolts respectively.


There is no consensus on MLR collection parameters in Brazilian children and adolescents. Still, the Pa latency average and Na-Pa amplitude found in Brazilian normal-hearing children and adolescents evaluated on the eight articles of this review agreed with normative parameters established internationally.

Palavras-chave : Review; Hearing; Evoked potentials, Auditory; Child; Adolescent.

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