Amstadter et al, 2010 1919 Amstadter AB, Koenen KC, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, et al. NPY Moderates the Relation between Hurricane Exposure and Generalized Anxiety Disorder in an Epidemiologic Sample of Hurricane-Exposed Adults. Depress Anxiety. 2010;27(3):270-5. DOI: 10.1002/da.20648 https://doi.org/10.1002/da.20648...
|
NPY |
Rs16147 |
Patients, 41 Controls, 575 |
USA (Florida) |
Adults |
TaqMan |
Association with increased risk of GAD |
Carlino et al, 2015 2020 Carlino D, Francavilla R, Baj G, Kulak K, d'Adamo P, Ulivi S, et al. Brain-derived neurotrophic factor serum levels in genetically isolated populations: gender-specifc association with anxiety disorder subtypes but not with anxiety levels or Val66Met polymorphism. peerJ. 2015;3:e1252. DOI: 10.7717/peerj.1252. https://doi.org/10.7717/peerj.1252...
|
BDNF |
Val66Met (rs6265) |
Patients, 91 Controls, 581 |
North-Eastern Italy |
Adults |
Illumina array |
Association with GAD in females |
Sipilä et al, 2010 2121 Sipilä T, Kananen L, Greco D, Donner J, Silander K, Terwilliger JD, et al. An Association Analysis of Circadian Genes in Anxiety Disorders. Biol Psychiatry. 2010;67(12):1163-70. DOI: 10.1016/j.biopsych.2009.12.011 https://doi.org/10.1016/j.biopsych.2009....
|
BLC2 DRD2 |
Rs12454712 Rs4245146 |
Patients, 103 Controls, 206 |
Finland |
Adults |
Sequenom MassArray |
Association with GAD. Association with GAD. |
Koenen et al, 2009 22 Koenen KC, Amstadter AB, Ruggiero KJ, Acierno R, Galea S, Kilpatrick DG, et al. RGS2 and Generalized Anxiety Disorder in an Epidemiologic Sample of Hurricane-Exposed Adults. Depress Anxiety. 2009;26(4):309-15. DOI: 10.1002/da.20528 https://doi.org/10.1002/da.20528...
|
RGS2 |
Rs4606 |
Patients, 41 Controls, 566 |
USA (Florida) |
Adults |
TaqMan |
Association with GAD. |
Molina et al, 2011 2222 Molina E, Cervilla J, Rivera M, Torres F, Bellon JA, Moreno B, et al. Polymorphic variation at the serotonin 1-A receptor gene is associated with comorbid depression and generalized anxiety. Psychiatr Genet. 2011;21(4):195-201. DOI: 10.1097/YPG.0b013e3283457a48 https://doi.org/10.1097/YPG.0b013e328345...
|
HTR1A |
C(-1019)G |
Patients, 85 Controls, 974 |
Spain |
Adults and Elderly |
Sequenom MassArray |
Association with comorbid MD and GAD. |
Moreira et al, 2015 44 Moreira FP, Fabião JD, Bittencourt G, Wiener CD, Jansen K, Oses JP, et al. The Met allele of BDNF Val66Met polymorphism is associated with increased BDNF levels in generalized anxiety disorder. Psychiatric Genetics. 2015;25(5):201-7. DOI: 10.1097/YPG.0000000000000097 https://doi.org/10.1097/YPG.000000000000...
|
BDNF |
Val66Met |
Patients, 121 Controls, 695 |
Brazil |
Adults |
TaqMan |
Met allele associated with increased BDNF in GAD. |
Tadic et al, 2003 2323 Tadic A, Rujescu D, Szegedi A, Giegling I, Singer P, Möller HJ, et al. Association of a MAOA gene variant with generalized anxiety disorder, but not with panic disorder or major depression. Am J Med Genet B Neuropsychiatr Genet. 2003;117B(1):1-6. DOI: 10.1002/ajmg.b.10013 https://doi.org/10.1002/ajmg.b.10013...
|
MAOA |
T941G |
Patients, 34 Controls, 132 |
Germany |
Adults |
PCR-RFLP |
941T allele is associated with GAD in females. |
Ryan et al, 2011 2424 Ryan J, Scali J, Carrière I, Scarabin PY, Ritchie K, Ancelin ML. Estrogen receptor gene variants are associated with anxiety disorders in older women. Psychoneuroendocrinology. 2011;36(10):1582-6. DOI: 10.1016/j.psyneuen.2011.04.011 https://doi.org/10.1016/j.psyneuen.2011....
|
ESR2 ESR1 |
Rs1256049 Rs2234693 RS9340799 rs498693 rs1271572 |
Patients, 87 Controls, 850 |
France |
Elderly |
PCR SNP KASPar |
The A allele is associated with an increased risk of GAD. No association. No association. No association. No association. |
Wang et al, 2015 2525 Wang Y, Zhang H, Li Y, Wang Z, Fan Q, Yu S, et al. BDNF Val66Met polymorphism and plasma levels in Chinese Han population with obsessive-compulsive disorder and generalized anxiety disorder. J Affect Disord. 2015;186:7-12. DOI: 10.1016/j.jad.2015.07.023. https://doi.org/10.1016/j.jad.2015.07.02...
|
BDNF |
Val66Met (rs6265) |
Patients, 108 Controls, 99 |
China |
Adults |
TaqMan |
No association. |
You et al, 2005 2626 You JS, Hu SY, Chen B, Zhang HG. Serotonin transporter and tryptophan hydroxylase gene polymorphisms in Chinese patients with generalized anxiety disorder. Psychiatr Genet. 2005;15(1):7-11. DOI: 10.1097/00041444-200503000-00002 https://doi.org/10.1097/00041444-2005030...
|
5-HTT TPH |
5-HTTLPR 5-HTT VNTR A218C |
Patients, 138 Controls, 90 |
China |
Adults |
PCR conventional |
SS genotype and S allele were associated with GAD. No association. No association. |