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vol.60 issue1Is radioactive iodine- 131 treatment related to the occurrence of non-synchronous second primary malignancy in patients with differentiated thyroid cancer? author indexsubject indexarticles search
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Archives of Endocrinology and Metabolism

Print version ISSN 2359-3997On-line version ISSN 2359-4292


ROSARIO, Pedro Weslley  and  MOURAO, Gabriela Franco. Is 131I ablation necessary for patients with low-risk papillary thyroid carcinoma and slightly elevated stimulated thyroglobulin after thyroidectomy?. Arch. Endocrinol. Metab. [online]. 2016, vol.60, n.1, pp.5-8. ISSN 2359-3997.


This prospective study evaluated the recurrence rate in low-risk patients with papillary thyroid cancer (PTC) who presented slightly elevated thyroglobulin (Tg) after thyroidectomy and who did not undergo ablation with131I.

Subjects and methods

The study included 53 low-risk patients (nonaggressive histology; pT1b-3, cN0pNx, M0) with slightly elevated Tg after thyroidectomy (> 1 ng/mL, but ≤ 5 ng/mL after levothyroxine withdrawal or ≤ 2 ng/mL after recombinant human TSH).


The time of follow-up ranged from 36 to 96 months. Lymph node metastases were detected in only one patient (1.9%). Fifty-two patients continued to present negative neck ultrasound. None of these patients without apparent disease presented an increase in Tg.


Low-risk patients with PTC who present slightly elevated Tg after thyroidectomy do not require ablation with 131I.

Keywords : Thyroid cancer; low-risk; postoperative thyroglobulin; radioiodine; recurrence.

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