SciELO - Scientific Electronic Library Online

 
vol.61 número1Influence of the use of testosterone associated with physical training on some hematologic and physical parameters in older rats with alloxan-induced diabetesImportance of abdominal circumference and body mass index values in predicting male hypogonadism – A practical approach índice de autoresíndice de assuntospesquisa de artigos
Home Pagelista alfabética de periódicos  

Serviços Personalizados

Journal

Artigo

Indicadores

Links relacionados

Compartilhar


Archives of Endocrinology and Metabolism

versão impressa ISSN 2359-3997versão On-line ISSN 2359-4292

Resumo

BATISTA, Gisele Almeida et al. Body composition, resting energy expenditure and inflammatory markers: impact in users of depot medroxyprogesterone acetate after 12 months follow-up. Arch. Endocrinol. Metab. [online]. 2017, vol.61, n.1, pp.70-75.  Epub 05-Set-2016. ISSN 2359-4292.  http://dx.doi.org/10.1590/2359-3997000000202.

Objective

The aim of this study was to evaluate for 12 months the changes of body weight using Depot Medroxyprogesterone Acetate (DMPA) and if these changes are related to inflammatory markers.

Subjects and methods

Twenty women of childbearing age who chose the DMPA, without previous use of this method, BMI < 30 kg/m2, and 17 women using IUD TCu 380A, participated in the study. At the baseline and after one year, changes in weight gain, body composition by the bioimpedance electric method, resting energy expenditure (REE) by the indirect calorimetry method, inflammatory markers and HOMA-IR were assessed.

Results

After 12 months of evaluation, we could observe a significant increase in the DMPA group in weight (3,01 kg) and BMI, while the IUD group’s only significant increase was observed in the BMI. Relative to REE there was an increase of basal metabolic rate (BMR) in both groups after one year. The sub-group DMPA that gained < 3 kg had increased significant weight, BMI and body surface (BS) with respiratory quotient (RQ) reduction, while the sub-group that gained ≥ 3 kg had a significant increase in weight, BMI, BS, fat-free mass, fat mass, BMR, Leptin, HOMA-IR and waist circumference, with RQ significantly reduced.

Conclusion

Our study found significant changes in weight, body composition and metabolic profile of the population studied in the first 12 months of contraceptive use. These changes mainly increased body weight, leptin levels and HOMA-IR which can contribute to the development of some chronic complications, including obesity, insulin resistance and diabetes mellitus.

Palavras-chave : Obesity; body composition; resting energy expenditure; depot medroxyprogesterone acetate; leptin.

        · texto em Inglês     · Inglês ( pdf )