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Archives of Endocrinology and Metabolism

Print version ISSN 2359-3997On-line version ISSN 2359-4292


GOMES, Júnia Maria Geraldo; FABRINI, Sabrina Pinheiro  and  ALFENAS, Rita de Cássia Gonçalves. Low glycemic index diet reduces body fat and attenuates inflammatory and metabolic responses in patients with type 2 diabetes. Arch. Endocrinol. Metab. [online]. 2017, vol.61, n.2, pp.137-144.  Epub Sep 05, 2016. ISSN 2359-3997.


The aim of this study was to verify the effects of glycemic index (GI) on body composition, and on inflammatory and metabolic markers concentrations in patients with type 2 diabetes.

Subjects and methods

In this randomized controlled parallel trial, twenty subjects (aged 42.4 ± 5.1 years, BMI 29.2 ± 4.8 kg.m-2) were allocated to low GI (LGI) (n = 10) or high GI (HGI) (n = 10) groups. Body composition, inflammatory and metabolic markers were assessed at baseline and after 30 days of intervention. Food intake was monitored during the study using three-day food records completed on two non-consecutive weekdays and on a weekend day.


Body fat reduced after the LGI intervention compared with baseline (P = 0.043) and with the HGI group (P = 0.036). Serum fructosamine concentration (P = 0.031) and TNF-α mRNA expression (P = 0.05) increased in the HGI group. Serum non-esterified fatty acids were greater in the HGI than in the LGI group (P = 0.032). IL-6 mRNA expression tended to decrease after the consumption of the LGI diet compared to baseline (P = 0.06).


The LGI diet reduced body fat and prevented the negative metabolic and inflammatory responses induced by the HGI diet.

Keywords : Glycemic index; inflammation; metabolic profile; diabetes mellitus; body fat.

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