Fama’ and cols., this study |
One (2014) |
France |
207 pts |
TT |
In 25/207 (12.1%) pts, 37 PTC were detected (31 microPTCs and 6 PTCs) |
10/25 (40.0%) pts had multifocal tumours; all pts underwent surgery for MNG |
Daumerie and cols., 1998 |
1976 - 1995 |
Belgique |
93 pts |
TT in 16/47 (34.0%) pts with MNG (group I), PT in 39/46 (84.8%) pts with a solitary hot nodule (group II) |
2/16 (12.5%) pts (group I) and 5/39 (12.8%) pts (group II) had microTC, with a total prevalence of 12.7% |
|
Dănilă and cols., 2008 |
2000 - 2006 |
Germany |
92 pts |
TT |
2/92 (2.2%) pts had microPTC (tumour size ranged from 3 to 5 mm) |
All pts had GD; multifocality and lymph node involvement were not detected |
Pezzolla and cols., 2014 |
Jan 2010 - Jun 2013 |
Italy |
256 pts |
Surgical procedures in tumours pts 28/256): TT in 27/28, PT in 1/28 PT |
In 28/256 (10.9%) pts, 40 TCs were detected (29 FV-PTC, 10 PTC and 1 FTC) |
Pts underwent surgery for: 176 pts (MNG), 67 pts (GD), 12 pts (UNG) and 1 pt (PD) |
Pezzolla and cols., 2010 |
n/a |
Italy |
165 pts |
n/a |
30/165 (18.2%) pts had TC (18 PTC, 6 FTC, 5 FV-PTC and 1 oncocytic carcinoma); 15/30 (50%) were microcarcinomas |
Pts underwent surgery for: 132 pts (MNG), 30 pts (UNG), 2 pts (PD) and 1 pt (GD) |
Costamagna and cols., 2013 |
2001 - 2009 |
Italy |
568 pts |
TT in 499/568, PT in 69/568 |
53/568 (9.3%) pts had TC (24 FV-PTC, 20 PTC, 4 FTC, 4 MTC and 1 primitive thyroid paraganglioma); 32/53 (60.4%) had microPTCs |
14/53 (26.4%) pts had multifocal tumours and in 12/53 (22.6%) were bilateral |
Negro and cols., 2013
|
2000 - 2010 |
Italy |
970 pts |
TT |
84/ 970 (8.7%) pts had TC |
|
Botrugno and cols., 2011 |
2000 - 2008 |
Italy |
462 pts |
TT |
41/462 (8.9%) pts had TC; the most common histotype was PTC |
|
Gelmini and cols., 2010 |
10 yrs |
Italy |
739 pts |
TT in 503/739, PT in 239/739 |
82/739 (11.1%) pts had TC, mainly microPTC |
Lymph-node metastases were found in the 3.6% of cases |
Pisello and cols., 2007 |
Jan 2000 - Jan 2006 |
Italy |
502 pts |
TT in 458/502, PT in 44/502 |
17/502 (3.4%) pts had microPTC |
In 34/502 (6.8%) pts, tumours were suspected preoperatively; 2/502 (0.4% had multifocal microPTCs |
Carlini and cols., 2006
|
n/a |
Italy |
88 pts |
TT |
19/88 (21.6%) pts had TC |
|
Miccoli and cols., 2006 |
Feb 2002 - Nov 2003 |
Italy |
998 pts |
TT in 902/998 pts, PT in 96/998 |
104/998 (10.4%) pts had TC; the most common histotype was PTC (99/104) |
Tumours were multifocal in 19.8% of the cases |
Carlini and cols., 2005
|
1-year |
Italy |
n/a |
n/a |
Incidence of microTC was 27.4% |
|
Pingitore and cols., 1993 |
1985 - 1991 |
Italy |
2930 pts |
n/a |
132/2463 (5.4%) pts had TC |
2463/2930 pts were considered clinically benign and 467/2930 pts malignant, preoperatively |
Pascual Corrales and cols., 2012 |
n/a |
Spain |
372 pts |
n/a |
58/372 (15.6%) pts had TC |
Pts underwent surgery for: 49 pts (EMNG), 8 pts (GD) and 1 pt (HMNG) |
Slijepcevic and cols 2015 |
., 2008-2013 |
Serbia |
2466 pts |
TT or PT |
403/2466 (16.3%) pts had microPTC |
|
Zivaljević and cols., 2008 |
2004 |
Serbia |
578 pts |
n/a |
53/578 (9.2%) pts had microTC |
Pts underwent surgery for: 201 pts (MNG), 178 pts (thyroid adenoma), 89 pts (GD), 79 pts (PD) and 31 pt thyroiditis |
Alecu and cols., 2014 |
2002 - 2012 |
Romania |
145 pts |
TT in 102/145 pts, PT in 43/145 |
10/145 (6.9%) pts had microPTC |
|
Muntean and cols., 2013 |
2002 - 2011 |
Romania |
2168 pts |
TT or PT |
187/2168 (8.6%) pts had microPTC |
In 66/187 (35.3%) pts had multifocal tumours, and in 31/187 (16.6%) were bilateral |
Lukás and cols., 2010 |
2004 - 2008 |
Czech Republic |
400 pts |
TT or PT |
34/400 (8.5%) pts had microTC; 32/34 (94.1%) were microPTCs |
In 5/34 (14.7%) pts had multifocal tumours and in 4/34 (11.8%) were bilateral |
Nechaĭ and cols., 2012
|
2008 - 2009 |
Ukraine |
608 pts |
n/a |
56/608 (9.2%) pts had TC; 43/56 (76.8%) were microPTCs |
|
Barczyński and cols., 2011
|
1999 - 2009 |
Poland |
8132 pts |
TT in 2918/8132 pts, PT in 5214/8132 |
406/8132 (5.0%) pts had TC |
|
Vasileiadis and cols, 2013 |
2001 - 2009 |
Greece |
2236 pts |
TT |
268/2236 (12.0%) pts had microPTC. |
|
Siassakos and cols. 2008 |
Jan 1997 - Jul 2001 |
Greece |
191 pts |
TT |
29/191 (15.2%) pts had microTC (18 microFTC, 10 microPTC and 1 microMTC) |
In 8/29 (27.6%) pts had multifocal microcarcinomas |
Sakorafas and cols. 2007 |
Feb 1990 - Feb 2002 |
Greece |
380 pts |
TT in 377/380 pts, PT in 3/380 |
27/380 (7.1%) pts had microPTC |
In 11/27 (40.7%) pts had multifocal tumours |
Yazici and cols., 2015 |
2010-2013 |
Turkey |
86 pts |
TT or PT |
6/86 (7.0%) pts had TC (4 microPTC and 2 PTC) |
|
Tasova and cols., 2013 |
Mar 2007 - May 2011 |
Turkey |
443 pts |
TT in 401/443, PT in 42/443 |
66/443 (14.9%) pts had TC (56 PTC, 4 FTC and 6 indeterminate lesions) |
|
Karakoyun and cols 2013 |
Jan 2010 - Aug 2011 |
Turkey |
50 pts |
TT |
5/50 (10.0%) pts had microPTC. |
|
Berker and cols., 2011 |
Jan 2004 - Jan 2009 |
Turkey |
337 pts |
TT |
18/337 (5.3%) pts had microTC |
Pts underwent surgery for: 278 pts (MNG), 59 pts (GD) |
Tezelman and cols., 2009 |
1988-2007 |
Turkey |
2906 pts |
PT in 1695/2906 (group 1), TT in 1211/2906 (group 2) |
210/2906 (7.2%) pts had TC (81 in group 1 and 129 in group 2) |
|
Giles and cols., 2004 |
Sep 2001 - Dec 2002 |
Turkey |
218 pts |
TT in 109/218 (group 1), and PT in 109/218 (group 2) |
18/218 (8.3%) pts had PTC (10 in group 1 and 8 in group 2) |
All pts underwent surgery for MNG |
Fernando and cols., 2009 |
2003 - 2005 |
Sri Lanka |
68 pts |
TT |
6/68 (8.8%) pts had TC (2 PTC, 2 MTC and 2 FTC) |
|
John and cols., 2014 |
Jan 2005 - Jun 2012 |
India |
1300 pts |
TT or PT |
94/1300 (7.2%) pts had microPTC |
|
Wu and cols., 1993 |
1962 - 1991 |
China |
135 pts |
n/a |
54/135 (40.0%) pts had TC |
|
Koh and cols., 1992 |
n/a |
Malaysia |
107 pts |
n/a |
8/107 (7.5%) pts had TC, mainly PTC |
All pts underwent surgery for MNG |
Preece and cols., 2014 |
Sep 1994 - Aug 2012 |
Australia |
1508 pts |
TT |
96/1508 (6.4%) pts had TC |
Pts underwent surgery for: 963 pts (MNG), 295 pts (TNG), 250 pts (GD) |
Bron and cols., 2004 |
1998-2002 |
Australia |
834 pts |
TT |
71/834 (8.5%) pts had TC (33 microPTC, 22 PTC, 11 FTC, 5 other) |
74/834 had previously undergone PT |
Bhuiyan and cols., 2015 |
2003-2008 |
South Africa |
90 pts |
TT |
10/90 (11.1%) pts had TC (3 PTC and 7 FTC) |
|
Bombil and cols., 2014 |
2005-2010 |
South Africa |
162 pts |
TT |
4/162 (2.5%) pts had PTC (3/4 were FV-PTC) |
|
Edino and cols., 2010 |
2000-2006 |
Nigeria |
160 pts |
n/a |
24/160 (15.0%) pts had TC (13 FTC, 10 PTC, 1 MTC and 1 ATC) |
In 6/25 (24.0%) pts tumours were detected preoperatively by FNAC |
Choong and cols., 2015 |
1990-2014 |
USA |
148 pts |
TT (120 pts) or PT (28 pts) |
7/148 (4.7%) pts had TC (5 PTC, 1 FTC and 1 MTC) |
All pts underwent surgery for TNG |
Ergin and cols., 2014 |
2005-2013 |
USA |
493 pts |
TT |
69/248 (28%) pts in EG group and 64/245 (26%) pts in GD group had microPTC |
Pts underwent surgery for: 248 pts (EG), 245 pts (GD) |
Bahl and cols., 2014
|
2003-2012 |
USA |
2090 pts |
n/a |
680/2090 (33%) pts had TC |
|
Phitayakorn and cols., 2013 |
Dec 1985 - Mar 2010 |
USA |
300 pts |
TT or PT |
31/300 (10.3%) pts had TC (22 microPTC, 8 PTC and 1 FTC) |
|
Phitayakorn and cols., 2008 |
1990-2007 |
USA |
506 pts |
TT, PT in 10 pts with GD |
11/333 (3.3%) nonTNG pts had PTC, 2/92 (2.2%) GD pts had microPTC, 5/81 (6.2%) TNG pts had TC (3 PTC, 1 FTC and 1 MTC) |
Pts underwent surgery for: 333 pts (nonTNG), 92 pts (GD), 81 pts (TNG) |
Smith and cols., 2013 |
2000-2011 |
USA |
1523 pts |
n/a |
238/1523 (15.6%) pts had TC (175 PTC, 39 FV-PTC, 11 FTC and 13 other malignancies) |
|
Smith and cols., 2013
|
2002-2011 |
USA |
164 pts |
n/a |
30/164 (18.3%) pts had TC |
All pts underwent surgery for TNG |
Dunki-Jacobs and cols., 2012 |
2001-2007 |
USA |
723 pts |
TT or PT |
194/723 (27%) pts had TC (PTC or microPTC) |
In 137/194 (70.6%) pts, tumours were suspected preoperatively |
Bradly and cols., 2009 |
Jan 2000 - May 2008 |
USA |
678 pts |
TT or PT |
81/678 (12%) pts had PTC |
|
Lokey and cols., 2005
|
Dec 1998-Dec 2003 |
USA |
738 pts |
n/a |
28/738 (3.8%) pts had TC (mainly microPTC) |
|