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Archives of Endocrinology and Metabolism

versão impressa ISSN 2359-3997versão On-line ISSN 2359-4292


WERNECK, Francisco Zacaron et al. Exercise training improves quality of life in women with subclinical hypothyroidism: a randomized clinical trial. Arch. Endocrinol. Metab. [online]. 2018, vol.62, n.5, pp.530-536. ISSN 2359-4292.


The aim was to evaluate the quality of life (HRQoL) in women with subclinical hypothyroidism (sHT) after 16 weeks of endurance training.

Subjects and methods:

In the first phase, a cross-sectional study was conducted in which 22 women with sHT (median age: 41.5 (interquartile range: 175) years, body mass index: 26.2 (8.7) kg/m2, thyroid stimulating hormone > 4.94 mIU/L and free thyroxine between 0.8 and 1.3 ng/dL were compared to a group of 33 euthyroid women concerned to HRQoL. In the second phase, a randomized clinical trial was conducted where only women with sHT were randomly divided into two groups: sHT-Tr (n = 10) - participants that performed an exercise program - and sHT-Sed (n = 10) - controls. Exercise training consisted of 60 minutes of aerobic activities (bike and treadmill), three times a week, for 16 weeks. The HRQoL was assessed by the SF-36 questionnaire in the early and at the end of four months.


Women with sHT had lower scores on functional capacity domain in relation to the euthyroid ones (770 ± 23.0 vs. 88.8 ± 14.6; p = 0.020). The sHT-Tr group improved functional capacity, general health, emotional aspects, mental and physical component of HRQoL after training period, while the sHT-Sed group showed no significant changes.


After 16 weeks of aerobic exercise training, there were remarkable improvements in HRQoL in women with sHT.

Palavras-chave : Hypothyroidism; quality of life; exercise training; functional capacity.

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