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Journal of Physical Education

versão On-line ISSN 2448-2455

Resumo

MIRI, Andressa Leticia et al. STUDY OF L-TRYPTOPHAN IN AN EXPERIMENTAL MODEL OF DEPRESSION CAUSED BY ALZHEIMER’S DISEASE. J. Phys. Educ. [online]. 2017, vol.28, e2839.  Epub 26-Out-2017. ISSN 2448-2455.  http://dx.doi.org/10.4025/jphyseduc.v28i1.2839.

Alzheimer’s is a neurodegenerative disease characterized by cognitive impairment commonly associated with mood disorders, which trigger depressive reactions and compromise mental performance and functionality. The objective of the present study was to verify the effects of L-tryptophan and to analyze motor behavior in an experimental model of depression caused by the Alzheimer’s disease process. The sample consisted of 40 Wistar rats divided equally into two groups, 20 animals treated with L-tryptophan and 20 control animals. Both groups received spatial memory training in the water maze task and were submitted to stereotaxic surgery to induce dementia. The treated group achieved better spatial memory activity than the control group in the Morris water maze. Treatment with L-tryptophan had beneficial effects on reactive memory.

Palavras-chave : Alzheimer’s Disease; Depression; Serotonin; Tryptophan..

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