Rho et al. (2010) [1919. Rho YH, Chung CP, Solus JF, Raggi P, Oeser A, Gebretsadik T, et al. Adipocytokines, insulin resistance, and coronary atherosclerosis in rheumatoid arthritis. Arthritis Rheum. 2010;62(5):1259–64.] |
Cross-sectional study evaluating correlation between HOMA-IR and serum adipokine levels. |
169 RA patients |
Positive correlation between serum leptin and insulin resistance. |
Targońska-Stepniak et al. (2010) [2020. Targońska-Stepniak B, Dryglewska M, Majdan M. Adiponectin and leptin serum concentrations in patients with rheumatoid arthritis. Rheumatol Int. 2010;30:731–7.] |
Cross-sectional study evaluating correlation between disease activity and serum adipokine levels. |
80 RA patients |
Positive correlation between serum leptin and DAS28. |
Yoshino et al. (2011) [2121. Yoshino T, Kusunoki N, Tanaka N, Kaneko K, Kusunoki Y, Endo H, et al. Elevated serum levels of resistin, leptin, and adiponectin are associated with C-reactive protein and also other clinical conditions in rheumatoid arthritis. Intern Med. 2011;50(4):269–75. https://www.ncbi.nlm.nih.gov/pubmed/21325757
https://www.ncbi.nlm.nih.gov/pubmed/2132...
] |
Case-control study evaluating correlation between inflammation markers and serum adipokine levels. |
141 RA patients 146 controls without RA |
Positive correlation between serum leptin and CRP. |
Kontunen et al. (2011) [2222. Kontunen P, Vuolteenaho K, Nieminen R, Lehtimäki L, Kautiainen H, Kesäniemi Y, et al. Resistin is linked to inflammation, and leptin to metabolic syndrome, in women with inflammatory arthritis. Scand J Rheumatol. 2011; 40(4):256–62. http://www.ncbi.nlm.nih.gov/pubmed/21453187
http://www.ncbi.nlm.nih.gov/pubmed/21453...
] |
Cross-sectional study evaluating correlation between serum adipokines levels and markers of inflammation and MetS. |
54 RA patients, 20 with MetS |
Increased levels of serum leptin observed only in patients with MetS. |
Olama et al. (2012) [1515. Olama SM, Senna MK, Elarman M. Synovial/serum leptin ratio in rheumatoid arthritis: the association with activity and erosion. Rheumatol Int. 2012;32(3): 683–90. http://www.ncbi.nlm.nih.gov/pubmed/21140264
http://www.ncbi.nlm.nih.gov/pubmed/21140...
] |
Case-control study evaluating differences between serum leptin and synovial/serum leptin ratio. |
40 RA patients 30 controls without RA |
Inverse correlation between leptin concentration and protection of joints in severe RA. |
Allam e Radwan (2012) [2828. Allam A, Radwan A. The relationship of serum leptin levels with disease activity in Egyptian patients with rheumatoid arthritis. Egypt Rheumatol. 2012;34(4):185–90.] |
Case-control study evaluating correlation between serum leptin levels and disease activity. |
37 RA patients 34 controls without RA |
No correlation between leptin levels and disease activity. |
Kang et al. (2013) [2323. Kang Y, Park H-J, Kang M-I, Lee H-S, Lee S-W, Lee S-K, et al. Adipokines, inflammation, insulin resistance, and carotid atherosclerosis in patients with rheumatoid arthritis. Arthritis Res Ther. 2013;15(6):1–7. http://www.ncbi.nlm.nih.gov/pubmed/24245495
http://www.ncbi.nlm.nih.gov/pubmed/24245...
] |
Cross-sectional study evaluating correlation between adipokine levels, inflammation markers, insulin resistance and atherosclerosis. |
192 RA patients |
Positive correlation between serum leptin and TNF-α and metabolic risk, including insulin resistance |
Mirfeizi et al. (2014) [3030. Mirfeizi Z, Noubakht Z, Rezaie AE, Jokar MH, Sarabi ZS. Plasma levels of leptin and visfatin in rheumatoid arthritis patients; is there any relationship with joint damage? Iran J Basic Med Sci. 2014;17(9):662–6. http://www.ncbi.nlm.nih.gov/pubmed/25691942
http://www.ncbi.nlm.nih.gov/pubmed/25691...
] |
Cross-sectional study evaluating correlation between adipokine levels and radiographic joint damage. |
54 RA patients (29 with erosion and 25 without erosion) |
No differences in serum leptin between the two groups. |
Abdalla et al. (2014) [2929. Abdalla M, Effat D, Sheta M, Hamed WE. Serum Leptin levels in rheumatoid arthritis and relationship with disease activity. Egypt Rheumatol. 2014;36(1):1–5.] |
Case-control study evaluating correlation between serum leptin levels and clinical manifestations of disease activity. |
60 RA patients 30 healthy controls |
No correlation between leptin levels and clinical and laboratorial markers of disease activity. |
Bustos Rivera-Bahena et al. (2015) [2424. Bustos Rivera-Bahena C, Xibillé-Friedmann DX, González-Christen J, Carrillo-Vázquez SM, Montiel-Hernández JL. Peripheral blood Leptin and Resistin levels as clinical activity biomarkers in Mexican rheumatoid arthritis patients. Reumatol Clin. 2016;12(6):323–6.] |
Cross-sectional study evaluating correlation between adipokine levels and disease activity. |
121 RA patients |
Positive correlation between serum leptin and disease activity. |
Xibille-Friedmann et al. (2015) [2525. Xibille-Friedmann DX, Ortiz-Panozo E, Bustos Rivera-Bahena C, Sandoval-Rios M, Hernandez-Gongora SE, Dominguez-Hernandez L, et al. Leptin and adiponectin as predictors of disease activity in rheumatoid arthritis. Clin Exp Rheumatol. 2015;33(4):471–7.] |
Cohort study evaluating if baseline levels of adipokines may predict disease activity or response to treatment. |
127 RA patients after 6 months of follow up; 91 after 1 year of follow up; 52 after 2 years of follow up |
Positive correlation between serum leptin and prevention of disease activity progression. |
Oner et al. (2015) [3131. Oner SY, Volkan O, Oner C, Mengi A, Direskeneli H, Tasan DA. Serum leptin levels do not correlate with disease activity in rheumatoid arthritis. Acta Reumatol Port. 2015;40(1):50–4.] |
Case-control study evaluating correlation between serum leptin levels and disease activity. |
106 RA patients 52 healthy controls 37 osteoarthritis patients |
No correlation between serum leptin and disease activity. |
Lee e Bae (2016) [2727. Lee YH, Bae S-C. Circulating leptin level in rheumatoid arthritis and its correlation with disease activity: a meta-analysis. Z Rheumatol. 2016;75(10): 1021–7.] |
Meta-analysis evaluating correlation between serum leptin levels and disease activity. |
13 studies: 648 RA patients 426 controls without RA |
Leptin levels significantly higher in RA patients and weak positive correlation between leptin levels and disease activity. |