ABSTRACT
BACKGROUND AND OBJECTIVES:
The constant search for bioactive compounds with anti-inflammatory and antinociceptive activities are of interest to research centers. For the characterization of these activities, trials on guinea pigs are necessary. Therefore, the purpose of this study was to demonstrate some methods to evaluate the anti-inflammatory and antinociceptive potential of natural products.
CONTENTS:
A stimulus is required to evaluate these activities, and the induction of inflammatory or nociceptive process can be by chemical inducers like formaldehyde, carrageenan, among others, or electronic equipment such as the hot plate. For all assays, the baseline and post-dose measurement of the studied compound is always compared with a control group. The planning of the experiment, as well as its conduct in accordance with well-established protocols, are important tools in the success of the work. The tests presented evaluated the antinociceptive and anti-inflammatory activity as well as the mechanisms involved.
CONCLUSION:
It was possible to evaluate that the tests present in the literature today meet the researcher’s need for the elucidation of the anti-inflammatory and antinociceptive activity of new compounds.
Keywords:
Abdominal contortion; Formalin; Hot plate; Paw edema