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Pathogenesis of Schistosoma mansoni infection

Abstract

In this paper a discussin is made on the pathogenesis of schistosomiasis mansoni in mice, presented from the perspectives of "processes", "mediators", "strategies for study" and vasculitis are discussed. The role of mediators, including cells, antibodies and immune complexes, cytokines and distal mediators is commented as related to the pathological processes occuring in schistosomiasis. Finally, strategies for study are presented, followed by a discussion on the etiopathogenesis of the different clinical stages and pathologic manifestations of schistosomiasis mansoni.

schistosomiasis; Schistosoma mansoni; mice; pathogenesis


ABSTRACT

Pathogenesis of Schistosoma mansoni infection

Allen W. Cheever1

NIH, NIAID, Laboratory of Parasitic Diseases, Bethesda, USA

In this paper a discussin is made on the pathogenesis of schistosomiasis mansoni in mice, presented from the perspectives of "processes", "mediators", "strategies for study" and vasculitis are discussed. The role of mediators, including cells, antibodies and immune complexes, cytokines and distal mediators is commented as related to the pathological processes occuring in schistosomiasis. Finally, strategies for study are presented, followed by a discussion on the etiopathogenesis of the different clinical stages and pathologic manifestations of schistosomiasis mansoni.

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Publication Dates

  • Publication in this collection
    04 June 2009
  • Date of issue
    1992
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