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Anais da Academia Brasileira de Ciências

Print version ISSN 0001-3765

An. Acad. Bras. Ciênc. vol.72 n.2 Rio de Janeiro June 2000

http://dx.doi.org/10.1590/S0001-37652000000200018 

EFFECT OF THE ESSENTIAL OIL FROM Piper solmsianum C.DC. LEAVES IN MICE BEHAVIOUR*

Davyson de L. Moreira1, Patrícia O. dos Santos1, Nuno A. Pereira2, Geraldo L. Cardoso2, Elsie F. Guimarães3 and Maria Auxiliadora C. Kaplan1

1Núcleo de Pesquisas de Produtos Naturais, Universidade Federal do Rio de Janeiro.
2
Departamento de Farmacologia Básica e Clínica, Universidade Federal do Rio de Janeiro.
3
Jardim Botânico do Rio de Janeiro.

 

The leaf essential oil from Piper solmsianum was obtained by hydrodistillation using a Clevenger-type apparatus. GC/MS analysis of this oil showed to be composed by monoterpenes, sesquiterpenes and arylpronanoids. Sarisan (39.23%) and D3-carene (23.29%) were identified as the major constituents of the volatile mixture. The P. solmsianum essential oil and its major compound (sarisan) were tested to verify their influence upon mice behaviour. Groups of adult albino mice were used in each experiment. Emulsions of the essential oil (5.0% and 10.0%, v/v) and of sarisan (5.0%, v/v) were prepared. The animals received the essential oil i.p. in the preliminary tests. The oil was also tested with pentobarbital (30mg/kg s.c.) and with diazepam (2.5mg/kg s.c.). Pure emulsions of sarisan were also tested as well as combination of sarisan with pentobarbital. Both essential oil and sarisan showed to have exciting and depressant effects on the tested animals.

—  ( November 23, 1999 ) .

* Supported by: CNPq/CAPES.