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Anais da Academia Brasileira de Ciências

Print version ISSN 0001-3765On-line version ISSN 1678-2690

An. Acad. Bras. Ciênc. vol.72 n.3 Rio de Janeiro Sept. 2000

http://dx.doi.org/10.1590/S0001-37652000000300035 

SUBCORTICAL CONNECTIONS OF AREA V4 IN THE MACAQUE*

RICARDO GATTASS3, CLAUDIA DISTLER4, ROBERT DESIMONE2 AND LESLIE G. UNGERLEIDER1

1Laboratory of Brain and Cognition
2Laboratory of Neuropsychology, National Institute of Mental Health, NIH, Bethesda, Maryland 20892 USA.
3Laboratory of Cognitive Physiology, Instituto de Biofisica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, 21941-900 Rio de Janeiro, RJ, Brazil.
4Department of Zoology and Neurobiology, Ruhr University Bochum, D-44780 Bochum, Germany.

 

To determine the subcortical efferent and afferent connections o visual area V4, we injected tritiated amino acids, wheat germ agglutinin conjugated to horseradish peroxidase (WGA-HRP), and the retrograde fluorescent tracers, fast blue, diamidine yellow, and bisbenzimide under electrophysiological guidance into 20 sites in V4 in 10 hemispheres of 9 macaque monkeys. The injection sites included the representations raging from the fovea to far peripheral eccentricities in both the upper (4) and lower visual field (17). The results indicated that V4 receives afferent inputs from dorsal raphe, medial raphe, locus coeruleus, and the ventral tegmentum. V4 has bi-directional connections with the lateral basal nuclei of the amigdala, the pulvinar and the claustrum. It has bi-directional topographic projections with four different portions of the inferior and lateral pulvinar and two different portions of the claustrum. V4 projects to the superficial and intermediate layers of the superior colliculus, to the thalamic reticular nucleus, to the interlaminar portions of the lateral geniculate nuclei, the posterior portion of the putamen and virtually the entire caudate nuclei. The projections to the caudate nuclei occupy the dorsomedial portion of the head, the entire body, and posterior part of the tail of the nuclei. — ( June 27, 2000 )

 

* Supported by PRONEX/ MCT, CNPq, NIH, FAPERJ.
E-mail: rgattass@biof.ufrj.br

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