Características histológicas de bolhas filtrantes de pacientes submetidos à trabeculectomia com uso de 5-FU no intra-operatório

Histologic characteristics of filtering blebs in patients submitted to trabeculectomy with intraoperatively use of 5-FU

RESUMO

Os autores avaliaram o aspecto histológico da conjuntiva de bolhas filtrantes de dois pacientes que foram submetidos a revisão cirúrgica do sítio de filtração após trabeculectomia com uso de 5-Fluorouracil no intra-operatório. As bolhas foram excisadas devido aos olhos apresentarem hipotonia persistente. A microscopia óptica mostrou: atenuação do epitélio conjuntival, estroma com colágeno frouxamente organizado, poucos vasos sangüíneos e raras células inflamatórias. O resultado da análise histopatológica é semelhante aqueles descritos na literatura para casos tratados com mitomicina-C.

Palavras-chave:
5-Fluorouracil; Trabeculectomia; Hipotonia ocular; Anatomia patológica

SUMMARY

Authors studied the histological aspects of filtering blebs conjunctiva of two patients who had undergone surgical revision of the filtration site after trabeculectomy with 5-Fluorouracil during the procedure. Blebs were excised due to ocular hypotony. Light microscopy showed: conjunctival epithelium attenuation, substantia propria with loosely organized collagen, few blood vessels and rare inflammatory cells. Our histhopathological findings are similar to those reports in the literature for cases treated with mitomycin-C.

Key words:
5-Fluorouracil; Trabeculectomy; Ocular hypotony; Pathologic anatomy; Histology

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• Trabalho realizado no serviço de Glaucoma do HCFMUSP.

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Datas de Publicação

• Publicação nesta coleção
  Feb 1998