Eletroforese das proteínas do líqüido cefalorraquidiano I: considerações gerais sôbre a eletroforese em papel

Spina-França, A.

doi:10.1590/S0004-282X1958000200005

Resumos

Os caracteres gerais do método eletroforético são apresentados de modo sumário, especialmente aquêles referentes à eletroforese em papel, no sentido de familiarizar o neurologista quanto aos seus aspectos principais e sua utilização no estudo das frações proteicas do liqüido cefalorraquidiano cujos aspectos particulares são discutidos.

The main aspects of electrophoresis are summarised, specially those concerning paper electrophoresis, as a practical guide for neurologists, in its appliance to the study of cerebrospinal fluid protein fractions.

ATUALIZAÇÕES

Eletroforese das proteínas do líqüido cefalorraquidiano I. Considerações gerais sôbre a eletroforese em papel

Electrophoresis of cerebrospinal fluid proteins. General considerations on paper electrophoresis

A. Spina-França

Assistente extranumerário da Clínica Neurológica (Serviço do Prof. Adherbal Tolosa) e médico auxiliar de ensino no Laboratório Central (Serviço do Dr. Octavio A. Germeck) do Hospital das Clínicas da Fac. Med. da Univ. de São Paulo

RESUMO

Os caracteres gerais do método eletroforético são apresentados de modo sumário, especialmente aquêles referentes à eletroforese em papel, no sentido de familiarizar o neurologista quanto aos seus aspectos principais e sua utilização no estudo das frações proteicas do liqüido cefalorraquidiano cujos aspectos particulares são discutidos.

SUMMARY

The main aspects of electrophoresis are summarised, specially those concerning paper electrophoresis, as a practical guide for neurologists, in its appliance to the study of cerebrospinal fluid protein fractions.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Clínica Neurológica. Hospital das Clínicas da, Fac. Med. da Univ. de São Paulo - Caixa Postal 3461 - São Paulo, Brasil

1. ALY, F. W. - Untersuchungen über die elektrophoretisch isolierte Vorfraktion aus Liquor cerebrospinalis. Biochem. Zeitschrift., 325:505 (setembro, 2), 1954.
2. ANTONINI, F. M.; PI VA, G. - II frazionamento elettroforetico delle proteine del liquido cerebro-spinale in condizioni normali e patologiche. Settimana Medica, 40: 455 (setembro, 15), 1952.
3. AZÉRAD, E.; LEWIN, J.; GHATA, J. - L'électrophorese sur papier. Presse Méd., 64:717 (abril, 18), 1956.
4. AYROSA GALVÃO, P. A.; HOXTER, G. - Eletroforese das proteínas do sôro nas doenças hepáticas. Rev. Hospital das Clínicas, 12:153 (março-abril), 1957.
5. BAUDOUIN, A.; LEWIN, J.; HILLION, P. - Électrophorèse sur papier des protéines du liquide céphalorachidien. Étude des lipoprotéines. C. R. Soc. Biol., 147:1036 (junho, 27), 1953.
6. BAUDOUIN, A.; LEWIN, J.; HILLION, P. - Électrophorèse sur papier du liquide céphalorachidien: étude des glycoprotéines. C. R. Soc. Biol., 148:1033 (junho, 26), 1954.
7. BAUDOUIN, A.; LEWIN, J.; HILLION, P. - Les lipoprotéines du liquide céphalorachidien; composante lipoprotéinique de la fraction rapide X, protéine rapide du plasma C R. Soc. Biol., 149:1093 (junho, 11), 1955.
8. BAUER, H. - Über die Bedeutung der Papier Elektrophorese des Liquors für die klinische Forschung. Deut. Z. f. Nervenh., 170:381 (setembro), 1953.
9. BAUER, H. - Papierelektrophoretische Darstellung der proteingebundenen Kohlenhydrate und Lipoide des Liquors. Klin. Wehns., 32:612 (julho, 1), 1954.
10. BAUER, H. - Zur Frage der Identität der Liquorproteine mit den Eiweisskörpern des Blutserums. Besonderheiten der Liquorproteine hinsichtlich der Vorfraktion der γ-globuline und der proteingebundenen Lipide. Deut. Z. f. Nervenh., 175:354 (novembro), 1956.
11. BOOIJ, J. - Electrophoresis in cerebrospinal fluid proteins. Folia Psychiat., Neurol, et Neurochirurg. Neerlandica, 52: 247, 1949.
12. BOOIJ, J. - Electrophoresis in cerebrospinal fluid proteins. Folia Psychiat., Neurol, et Neurochirurg. Neerlandica, 53:502, 1950.
13. BOOIJ, J. - Electrophoresis in cerebrospinal fluid proteins. The significance of the γ-globulin fraction in particular. Folia Psychiat., Neurol, et Neurochirurg. Neerlandica, 55:137, 1952.
14. BOOIJ, J. - A new component in the electrophoresis diagram of the serum of patients suffering from poliomyelitis acuta anterior. Folia Psychiat., Neurol, et Neurochirurg. Neerlandica, 56:191, 1953.
15. BÜCHER, T.; MATZELT, D.; PETTE, D - Papierelektropherogramm der Eiweisskörper des Liquor cerebrospinalis. Naturwissenschaften, 39:114 (março), 1952.
16. BÜCHER, T.; MATZELT, D.; PETTE, D. - Papierelektrophorese von Liquor cerebrospinalis. Klin. Wchnschr., 30:325, 1952 In Zentralblatt ges. Neurol, u. Psychiat., 121:41 (janeiro), 1953.
17. CUMINGS, J. N. - The examination of the cerebrospinal fluid and cerebral cyst fluid by paper strip electrophoresis. J. Neurol., Neurosurg. a. Psychiat., 16:152 (agosto), 1953.
18. EATON, J. C.; GARDNER, M. O. - Separation of cerebrospinal fluid proteins by paper electrophoresis. Biochem. J., 55:25 (setembro), 1953.
19. ESSER, H.; HEINZLER. F. - Eine Methode zur Gewinnung der Proteine aus Liquor cerebrospinalis und anderen schwach Eiweisshaitigen Lösungen durch Filtration mit Überdruck für die Elektrophorese in Filterpapier. Klin. Wchnschr., 30:600 (julho, 1), 1952.
20. ESSER, H. - Die Liquoreiweisskörper des Menschen. Zentralblatt ges. Neurol, u. Psychiat., 122:68 (março), 1953.
21. ESSER, H. - Elektrophoretische Liquoreiweissuntersuchungen bei organischen Erkrankungen des Zentralnervensystems. Zentralblatt ges. Neurol, u. Psychiat., 123:226 (junho), 1953.
22. EVVERBECK, H. - Die Elektrophoretische Darstellung normalen menschlichen Liquors. Kiin. Wchnschr., 28: 692 (outubro, 15), 1950.
23. FINE, J. M.; GROULADE, J.; SAINT-PAUL, M.; TIZZANI, R. J. - L'électrophorèse. Apport à la connaissance de la physiologie des protéines, glyco et lipoprotéines sériques chez l'homme et l'animal. Biol. Méd., 45:591 (dezembro), 1956.
24. FINE, J. M.; VINÇON-ABRIQ, A. E.; GROULADE, J. - Contribution à l'étude électrophorétique du sérum au cours des maladies du sang et des organes hématopoïétiques. Presse Méd., 62:1043 (julho, 7), 1954.
25. FISK, A. A.; CHANUTIN, A.: KLINGMAN, W. C. - Observations on a rapid migrating electrophoretic component of cerebrospinal fluid. Proc. Soc. Exper. Biol. a. Med., 78:1 (janeiro), 1951.
26. FLODEN, C. H. - Cerebrospinal fluid protein in syphilis. A methodological and clinical study, based on the Izikowitz method for fractional protein determination, and a comparison with paper electrophoretic protein determination. Acta Dermato-Vereneol., suplemento 32, 1955, 184 págs.
27. FRANTZEN, E. - A survey of methods for the determination of protein fractions in the cerebrospinal fluid. Acta Psychiat. et Neurol. Scandinavica, 30:217 (março), 1955.
28. GRASSMANN, W. - General methods of paper electrophoresis with examples of its uses in medical and biochemical problems. Symposium on Paper Electrophoresis, J. & A. Churchill Ltd., Londres, 1956, págs. 2-21.
29. GRASSMANN, W.; HANNIG, K. - Beiträge zur Methodik der Papierelektrophoretischen Serumanalyse. Klin. Wchnschr., 32:838 (setembro, 15), 1954.
30. GRIES, G.; ALY, F. W.; OLDERSHAUSEN, H. F. - Zur Methodik der Papierelektrophorese des Liquor Cerebrospinalis. Klin. Wchnschr., 31:644 (julho, 15), 1953.
31. GROGAN, C. H.; ROBOZ, E. - Simple apparatus for concentrating biologic fluids of low protein content. J. Laborat. a. Clin. Med., 45:495 (março), 1955.
32. HESSELVIK, L. - An electrophoretical study of normal and pathological body fluids. Acta Med. Scandinavica, 101:461, 1939.
33. HOCH, H.; CHANUTIN, A. - Electrophoretic studies on cerebrospinal fluid. Proc. Soc. Exper. Biol. a. Med., 81:628 (dezembro). 1952.
34. HOXTER, G. - Comunicação pessoal.
35. HÖXTER, G.; WAJCHENBERG, B. L. - Eletroforese das proteínas plasmáticas. Generalidades e método. Rev. Paulista de Med., 44:298 (abril), 1954.
36. HOXTER, G.; WAJCHENBERG, B. L. - Eletroforese das proteínas plasmáticas. Interpretação do traçado eletroforético do plasma humano normal e suas variações patológicas. Rev. Paulista de Med., 44:316 (abril), 1954.
37. HÖXTER, G.; WAJCHENBERG, B. L.; MUNGIOLI, R. - Analysis of electrophoretic patterns. Nature, 179:423 (fevereiro, 23), 1957.
38. KABAT, E. A.; LANDOW, H.; MOORE, D. H. - Electrophoretic patterns of concentrated cerebrospinal fluid. Proc. Soc. Exper. Biol. a. Med., 49:260 (fevereiro), 1942.
39. KABAT, E. A.; MOORE, D. H.; LANDOW, H. - An electrophoretic study of the protein components in cerebrospinal fluid and their relationship to the serum proteins. J. Clin. Invest., 21:571 (setembro), 1942.
40. KIKUCHI, J. - Electrophoretic analysis of protein in spinal fluid by meningitis. Folia Psychiat. et Neurol. Japonica, suplemento 2 (Proceedings XIV Annual Meeting of Japan Neurosurgical Society, 1955), págs. 3-4.
41. KITAMURA, K.; KATSUKI, T.; HARÁ, H. - Studies on protein in cerebrospinal fluid in neurosurgical diseases by paper-electrophoresis. Folia Psychiat. et Neurol. Japónica, suplemento 2 (Proceedings XIV Annual Meeting of Japan Neurosurgical Society, 1955), págs. 1-2.
42. KÖIW, E.; WALLE- NIUS, G.; GRÖNWALL, A. - Paper electrophoresis in clinical chemistry. A comparison with Tiselius original method. Scandinav. J. Clin. a. Laborat. Invest., 4:47, 1S52.
43. KUNKEL, H. G.; TISELIUS, A. - Electrophoresis of proteins on filter paper. J. Gen. Physiol., 35:89 (setembro, 20), 1951.
44. LABHART, H.; SCHWEIZER, W.: STAUB, H. - MikroeJektrophoretische Untersuchungen von normalen und pathologischen Liquor cerebrospinalis. Confinia Neurol., 11:325, 1951. In Excerpta Medica (VIII), 5:425 (maio), 1952.
45. LACIGA, Z.; ZIDOVÁ, V. - The paper electrophoresis contribution to the determination of types of cerebrospinal fluid. Formulae in nervous diseases. First Congress of Czechoslovak Neurologists. Jezenik-Lazne, 8-13 outubro, 1956, págs. 18-19.
46. LANGE, C. - Interpretation of findings in the cerebrospinal fluid. The technique and systematic interpretation of the albumin-globulin ratio in cerebrospinal fluids. J. Laborat. a. Clin. Med., 31:552 (maio), 1946.
47. LEDERER, M. - Introduction to Paper Electrophoresis and Related Methods. Elsevier Publish Co., Amsterdam, 1955, págs. 31-60.
48. LEWIN, J.; GHATA, J.; AZÉRAD, E. - Protéines rapides du sérum normal. Presse Méd., 64:1433 (agôsto, 25), 1956.
49. LEY, R. - Electrophoresigramme. Acta Neurol, et Psychiat. Bélgica, 57:536 (junho), 1957.
50. MADEIRA, F. - Eletroforese em papel. Gazeta Méd. Portuguêsa, 6:205 (janeiro-março), 1953.
51. MERKLEN, F. P.; MASSEYEFF, R. - L'adsorption d'albumine, cause d'erreur dans l'apréciation quantitative des protéines sériques dans l'électronhorèse sur papier filtre. C. R. Soc. Biol., 146:1905 (dezembro, 13), 1952.
52. MIES, H. J. - Einengung von Liquor cerebrospinalis als Verbeiterung zur Papierelektrophoresc. Klin. Wehnsehr., 31:159 (fevereiro, 15), 1953.
53. PETERS, H. J. - Paper electrophoresis of cerebrospinal fluid. Chem. Weekblad, 49:248. In Chem. Abstracts, 47:8171 (agôsto, 10 a outubro, 25), 1953.
54. PIEPER, J. - Über die Besonderen Eiweissfraktionen des Liquor cerebrospinalis. Klin. Wchnschr., 32:597 (julho, 1), 1954.
55. PRESS, E. M. - A comparative study of cerebrospinal fluid and serum proteins in multiple sclerosis with special reference to the Lange colloidal gold reaction. Biochem. J., 63:367 (julho), 1956.
56. PRUCKNER, F.: SCHWUTTKE, G - Methode zur Einengung des Liquor cerebrospinalis zur Herstellung von Elektro-Pherogrammen. Arch. Psychiat. u. Z. Neurol., 193:48 (fevereiro, 24), 1955.
57. ROBOZ, E.; HESS, W. C; TEMPLE, D. M.; WASHINGTON, M. S. - Paper electrophoretic estimation of protein in cerebrospinal fluid. J. Laborat. a. Clin. Med., 43: 785 (maio), 1954.
58. RODRIGUES, E.; RIBEIRO, L. P. - Montagem simples para eletroforese em papel para uso em laboratórios clínicos. O Hospital, 46:611 (dezembro), 1954.
59. SANDE, M. van; LOEWENTHAL, A.; KARCHER, D. - Interêt clinique des électrophorésigrammes des protéines du liquide céphalo-rachidien. Acta Neurol, et Psychiat. Bélgica, 57:523 (junho), 1957.
60. SCHEID, K. F.; SCHEID, L - Studies of the pathological physiology of cerebrospinal fluid. Electrophoretic separation of the proteins of the cerebrospinal fluid in inflammatory diseases of nervous system: a contribution to the pathological physiology of meningeal and cerebral blood vessels. Arch. Psychiat. Nervenkr., 117:219, 1944. In Chem. Abstracts, 43:9234 (setembro, 10 a novembro, 25), 1949.
61. SCHEID, K. F.; SCHEID, L. - Studies of the pathological physiology of cerebrospinal fluid. The colloidal chemical mechanism and pathophysiological significance of the mastic reaction and a modification thereof. Arch. Psychiat. Nervenkr., 118:316, 1948. In Chem. Abstracts, 43:3876 (março, 25), 1949.
62. SCHEID, K. F.; SCHEID, L.: SCHNEIDT, W. - Studies of the pathological physiology of cerebrospinal fluid. Comparative investigations of the colloid reactions, their colloidal chemical mechanism and their practical use in diagnosis. Arch. Psychiat. Nervenkr., 118:337, 1948. In Chem. Abstracts, 43:3877 (março, 25), 1949.
63. SCHMIDT, C; MATIAR, H. - Das quantitative Verhältnis der Serum und Liquor-proteine. Dtsch. Z. f. Nervenheilk., 174:443 (abril), 1956.
64. SCHÖNENBERG, H. - Die Papier-Elektrophorese des Liquor cerebrospinalis. Annales Paediatrici (Basiléia), 183:309 (novembro), 1954.
65. SMITH, J. K.; GERSTL, B.; DAVIS, W. E.; ORTH, D. L. - Lipoprotein patterns of spinal fluid obtained by paper electrophoresis. Arch. Neurol, a. Psychiat., 76:608 (dezembro), 1956.
66. SOMMERFELT, S. C. - Reproducibility with paper electrophoresis of serum proteins. Scandinav. J. Clin. a. Laborat. Invest., 4:307, 1952.
67. SOMMERFELT, S. C. - Some practical points regarding the reading of the paper electrophoretic strip. Symposium on Paper Electrophoresis, J. & A. Churchill Ltd., Londres, 1956, págs. 151-159.
68. STEGER, J. - Elektrophoretische Untersuchungen des Liquors. Dtsch. Z. f. Nervenheilk., 171:1 (novembro), 1953.
69. TISELIUS, A. - Electrophoresis of serum globulin. Electrophoresis analysis of normal and immune sera. Biochem. J., 31:1464, 1937.
70. TONINI, G.; INESI, G.; RISIO, C. de - Considerazione tecniche e metodologiche in campo di elettroforesi delle proteine liquorali. G. di Psiquiat. e di Neuropatol., 85:203, 1957.
71. VYMAZAL, J.; HOVORKOVÁ, B. - A contribution to the theory of the colloidal gold reaction. Ceskolovenská Neurologie, 19:207 (setembro), 1956.
72. WALLENIUS, G. - Electrophoretic patterns of cerebrospinal fluid and serum compared in normal and pathological conditions. Acta Societ. Med. Upsalliensis, 57:138 (junho, 20), 1952.

Datas de Publicação

Publicação nesta coleção
18 Fev 2014
Data do Fascículo
Jun 1958

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. ALY, F. W. - Untersuchungen über die elektrophoretisch isolierte Vorfraktion aus Liquor cerebrospinalis. Biochem. Zeitschrift., 325:505 (setembro, 2), 1954.

[2] 2. ANTONINI, F. M.; PI VA, G. - II frazionamento elettroforetico delle proteine del liquido cerebro-spinale in condizioni normali e patologiche. Settimana Medica, 40: 455 (setembro, 15), 1952.

[3] 3. AZÉRAD, E.; LEWIN, J.; GHATA, J. - L'électrophorese sur papier. Presse Méd., 64:717 (abril, 18), 1956.

[4] 4. AYROSA GALVÃO, P. A.; HOXTER, G. - Eletroforese das proteínas do sôro nas doenças hepáticas. Rev. Hospital das Clínicas, 12:153 (março-abril), 1957.

[5] 5. BAUDOUIN, A.; LEWIN, J.; HILLION, P. - Électrophorèse sur papier des protéines du liquide céphalorachidien. Étude des lipoprotéines. C. R. Soc. Biol., 147:1036 (junho, 27), 1953.

[6] 6. BAUDOUIN, A.; LEWIN, J.; HILLION, P. - Électrophorèse sur papier du liquide céphalorachidien: étude des glycoprotéines. C. R. Soc. Biol., 148:1033 (junho, 26), 1954.

[7] 7. BAUDOUIN, A.; LEWIN, J.; HILLION, P. - Les lipoprotéines du liquide céphalorachidien; composante lipoprotéinique de la fraction rapide X, protéine rapide du plasma C R. Soc. Biol., 149:1093 (junho, 11), 1955.

[8] 8. BAUER, H. - Über die Bedeutung der Papier Elektrophorese des Liquors für die klinische Forschung. Deut. Z. f. Nervenh., 170:381 (setembro), 1953.

[9] 9. BAUER, H. - Papierelektrophoretische Darstellung der proteingebundenen Kohlenhydrate und Lipoide des Liquors. Klin. Wehns., 32:612 (julho, 1), 1954.

[10] 10. BAUER, H. - Zur Frage der Identität der Liquorproteine mit den Eiweisskörpern des Blutserums. Besonderheiten der Liquorproteine hinsichtlich der Vorfraktion der γ-globuline und der proteingebundenen Lipide. Deut. Z. f. Nervenh., 175:354 (novembro), 1956.

[11] 11. BOOIJ, J. - Electrophoresis in cerebrospinal fluid proteins. Folia Psychiat., Neurol, et Neurochirurg. Neerlandica, 52: 247, 1949.

[12] 12. BOOIJ, J. - Electrophoresis in cerebrospinal fluid proteins. Folia Psychiat., Neurol, et Neurochirurg. Neerlandica, 53:502, 1950.

[13] 13. BOOIJ, J. - Electrophoresis in cerebrospinal fluid proteins. The significance of the γ-globulin fraction in particular. Folia Psychiat., Neurol, et Neurochirurg. Neerlandica, 55:137, 1952.

[14] 14. BOOIJ, J. - A new component in the electrophoresis diagram of the serum of patients suffering from poliomyelitis acuta anterior. Folia Psychiat., Neurol, et Neurochirurg. Neerlandica, 56:191, 1953.

[15] 15. BÜCHER, T.; MATZELT, D.; PETTE, D - Papierelektropherogramm der Eiweisskörper des Liquor cerebrospinalis. Naturwissenschaften, 39:114 (março), 1952.

[16] 16. BÜCHER, T.; MATZELT, D.; PETTE, D. - Papierelektrophorese von Liquor cerebrospinalis. Klin. Wchnschr., 30:325, 1952 In Zentralblatt ges. Neurol, u. Psychiat., 121:41 (janeiro), 1953.

[17] 17. CUMINGS, J. N. - The examination of the cerebrospinal fluid and cerebral cyst fluid by paper strip electrophoresis. J. Neurol., Neurosurg. a. Psychiat., 16:152 (agosto), 1953.

[18] 18. EATON, J. C.; GARDNER, M. O. - Separation of cerebrospinal fluid proteins by paper electrophoresis. Biochem. J., 55:25 (setembro), 1953.

[19] 19. ESSER, H.; HEINZLER. F. - Eine Methode zur Gewinnung der Proteine aus Liquor cerebrospinalis und anderen schwach Eiweisshaitigen Lösungen durch Filtration mit Überdruck für die Elektrophorese in Filterpapier. Klin. Wchnschr., 30:600 (julho, 1), 1952.

[20] 20. ESSER, H. - Die Liquoreiweisskörper des Menschen. Zentralblatt ges. Neurol, u. Psychiat., 122:68 (março), 1953.

[21] 21. ESSER, H. - Elektrophoretische Liquoreiweissuntersuchungen bei organischen Erkrankungen des Zentralnervensystems. Zentralblatt ges. Neurol, u. Psychiat., 123:226 (junho), 1953.

[22] 22. EVVERBECK, H. - Die Elektrophoretische Darstellung normalen menschlichen Liquors. Kiin. Wchnschr., 28: 692 (outubro, 15), 1950.

[23] 23. FINE, J. M.; GROULADE, J.; SAINT-PAUL, M.; TIZZANI, R. J. - L'électrophorèse. Apport à la connaissance de la physiologie des protéines, glyco et lipoprotéines sériques chez l'homme et l'animal. Biol. Méd., 45:591 (dezembro), 1956.

[24] 24. FINE, J. M.; VINÇON-ABRIQ, A. E.; GROULADE, J. - Contribution à l'étude électrophorétique du sérum au cours des maladies du sang et des organes hématopoïétiques. Presse Méd., 62:1043 (julho, 7), 1954.

[25] 25. FISK, A. A.; CHANUTIN, A.: KLINGMAN, W. C. - Observations on a rapid migrating electrophoretic component of cerebrospinal fluid. Proc. Soc. Exper. Biol. a. Med., 78:1 (janeiro), 1951.

[26] 26. FLODEN, C. H. - Cerebrospinal fluid protein in syphilis. A methodological and clinical study, based on the Izikowitz method for fractional protein determination, and a comparison with paper electrophoretic protein determination. Acta Dermato-Vereneol., suplemento 32, 1955, 184 págs.

[27] 27. FRANTZEN, E. - A survey of methods for the determination of protein fractions in the cerebrospinal fluid. Acta Psychiat. et Neurol. Scandinavica, 30:217 (março), 1955.

[28] 28. GRASSMANN, W. - General methods of paper electrophoresis with examples of its uses in medical and biochemical problems. Symposium on Paper Electrophoresis, J. & A. Churchill Ltd., Londres, 1956, págs. 2-21.

[29] 29. GRASSMANN, W.; HANNIG, K. - Beiträge zur Methodik der Papierelektrophoretischen Serumanalyse. Klin. Wchnschr., 32:838 (setembro, 15), 1954.

[30] 30. GRIES, G.; ALY, F. W.; OLDERSHAUSEN, H. F. - Zur Methodik der Papierelektrophorese des Liquor Cerebrospinalis. Klin. Wchnschr., 31:644 (julho, 15), 1953.

[31] 31. GROGAN, C. H.; ROBOZ, E. - Simple apparatus for concentrating biologic fluids of low protein content. J. Laborat. a. Clin. Med., 45:495 (março), 1955.

[32] 32. HESSELVIK, L. - An electrophoretical study of normal and pathological body fluids. Acta Med. Scandinavica, 101:461, 1939.

[33] 33. HOCH, H.; CHANUTIN, A. - Electrophoretic studies on cerebrospinal fluid. Proc. Soc. Exper. Biol. a. Med., 81:628 (dezembro). 1952.

[34] 34. HOXTER, G. - Comunicação pessoal.

[35] 35. HÖXTER, G.; WAJCHENBERG, B. L. - Eletroforese das proteínas plasmáticas. Generalidades e método. Rev. Paulista de Med., 44:298 (abril), 1954.

[36] 36. HOXTER, G.; WAJCHENBERG, B. L. - Eletroforese das proteínas plasmáticas. Interpretação do traçado eletroforético do plasma humano normal e suas variações patológicas. Rev. Paulista de Med., 44:316 (abril), 1954.

[37] 37. HÖXTER, G.; WAJCHENBERG, B. L.; MUNGIOLI, R. - Analysis of electrophoretic patterns. Nature, 179:423 (fevereiro, 23), 1957.

[38] 38. KABAT, E. A.; LANDOW, H.; MOORE, D. H. - Electrophoretic patterns of concentrated cerebrospinal fluid. Proc. Soc. Exper. Biol. a. Med., 49:260 (fevereiro), 1942.

[39] 39. KABAT, E. A.; MOORE, D. H.; LANDOW, H. - An electrophoretic study of the protein components in cerebrospinal fluid and their relationship to the serum proteins. J. Clin. Invest., 21:571 (setembro), 1942.

[40] 40. KIKUCHI, J. - Electrophoretic analysis of protein in spinal fluid by meningitis. Folia Psychiat. et Neurol. Japonica, suplemento 2 (Proceedings XIV Annual Meeting of Japan Neurosurgical Society, 1955), págs. 3-4.

[41] 41. KITAMURA, K.; KATSUKI, T.; HARÁ, H. - Studies on protein in cerebrospinal fluid in neurosurgical diseases by paper-electrophoresis. Folia Psychiat. et Neurol. Japónica, suplemento 2 (Proceedings XIV Annual Meeting of Japan Neurosurgical Society, 1955), págs. 1-2.

[42] 42. KÖIW, E.; WALLE- NIUS, G.; GRÖNWALL, A. - Paper electrophoresis in clinical chemistry. A comparison with Tiselius original method. Scandinav. J. Clin. a. Laborat. Invest., 4:47, 1S52.

[43] 43. KUNKEL, H. G.; TISELIUS, A. - Electrophoresis of proteins on filter paper. J. Gen. Physiol., 35:89 (setembro, 20), 1951.

[44] 44. LABHART, H.; SCHWEIZER, W.: STAUB, H. - MikroeJektrophoretische Untersuchungen von normalen und pathologischen Liquor cerebrospinalis. Confinia Neurol., 11:325, 1951. In Excerpta Medica (VIII), 5:425 (maio), 1952.

[45] 45. LACIGA, Z.; ZIDOVÁ, V. - The paper electrophoresis contribution to the determination of types of cerebrospinal fluid. Formulae in nervous diseases. First Congress of Czechoslovak Neurologists. Jezenik-Lazne, 8-13 outubro, 1956, págs. 18-19.

[46] 46. LANGE, C. - Interpretation of findings in the cerebrospinal fluid. The technique and systematic interpretation of the albumin-globulin ratio in cerebrospinal fluids. J. Laborat. a. Clin. Med., 31:552 (maio), 1946.

[47] 47. LEDERER, M. - Introduction to Paper Electrophoresis and Related Methods. Elsevier Publish Co., Amsterdam, 1955, págs. 31-60.

[48] 48. LEWIN, J.; GHATA, J.; AZÉRAD, E. - Protéines rapides du sérum normal. Presse Méd., 64:1433 (agôsto, 25), 1956.

[49] 49. LEY, R. - Electrophoresigramme. Acta Neurol, et Psychiat. Bélgica, 57:536 (junho), 1957.

[50] 50. MADEIRA, F. - Eletroforese em papel. Gazeta Méd. Portuguêsa, 6:205 (janeiro-março), 1953.

[51] 51. MERKLEN, F. P.; MASSEYEFF, R. - L'adsorption d'albumine, cause d'erreur dans l'apréciation quantitative des protéines sériques dans l'électronhorèse sur papier filtre. C. R. Soc. Biol., 146:1905 (dezembro, 13), 1952.

[52] 52. MIES, H. J. - Einengung von Liquor cerebrospinalis als Verbeiterung zur Papierelektrophoresc. Klin. Wehnsehr., 31:159 (fevereiro, 15), 1953.

[53] 53. PETERS, H. J. - Paper electrophoresis of cerebrospinal fluid. Chem. Weekblad, 49:248. In Chem. Abstracts, 47:8171 (agôsto, 10 a outubro, 25), 1953.

[54] 54. PIEPER, J. - Über die Besonderen Eiweissfraktionen des Liquor cerebrospinalis. Klin. Wchnschr., 32:597 (julho, 1), 1954.

[55] 55. PRESS, E. M. - A comparative study of cerebrospinal fluid and serum proteins in multiple sclerosis with special reference to the Lange colloidal gold reaction. Biochem. J., 63:367 (julho), 1956.

[56] 56. PRUCKNER, F.: SCHWUTTKE, G - Methode zur Einengung des Liquor cerebrospinalis zur Herstellung von Elektro-Pherogrammen. Arch. Psychiat. u. Z. Neurol., 193:48 (fevereiro, 24), 1955.

[57] 57. ROBOZ, E.; HESS, W. C; TEMPLE, D. M.; WASHINGTON, M. S. - Paper electrophoretic estimation of protein in cerebrospinal fluid. J. Laborat. a. Clin. Med., 43: 785 (maio), 1954.

[58] 58. RODRIGUES, E.; RIBEIRO, L. P. - Montagem simples para eletroforese em papel para uso em laboratórios clínicos. O Hospital, 46:611 (dezembro), 1954.

[59] 59. SANDE, M. van; LOEWENTHAL, A.; KARCHER, D. - Interêt clinique des électrophorésigrammes des protéines du liquide céphalo-rachidien. Acta Neurol, et Psychiat. Bélgica, 57:523 (junho), 1957.

[60] 60. SCHEID, K. F.; SCHEID, L - Studies of the pathological physiology of cerebrospinal fluid. Electrophoretic separation of the proteins of the cerebrospinal fluid in inflammatory diseases of nervous system: a contribution to the pathological physiology of meningeal and cerebral blood vessels. Arch. Psychiat. Nervenkr., 117:219, 1944. In Chem. Abstracts, 43:9234 (setembro, 10 a novembro, 25), 1949.

[61] 61. SCHEID, K. F.; SCHEID, L. - Studies of the pathological physiology of cerebrospinal fluid. The colloidal chemical mechanism and pathophysiological significance of the mastic reaction and a modification thereof. Arch. Psychiat. Nervenkr., 118:316, 1948. In Chem. Abstracts, 43:3876 (março, 25), 1949.

[62] 62. SCHEID, K. F.; SCHEID, L.: SCHNEIDT, W. - Studies of the pathological physiology of cerebrospinal fluid. Comparative investigations of the colloid reactions, their colloidal chemical mechanism and their practical use in diagnosis. Arch. Psychiat. Nervenkr., 118:337, 1948. In Chem. Abstracts, 43:3877 (março, 25), 1949.

[63] 63. SCHMIDT, C; MATIAR, H. - Das quantitative Verhältnis der Serum und Liquor-proteine. Dtsch. Z. f. Nervenheilk., 174:443 (abril), 1956.

[64] 64. SCHÖNENBERG, H. - Die Papier-Elektrophorese des Liquor cerebrospinalis. Annales Paediatrici (Basiléia), 183:309 (novembro), 1954.

[65] 65. SMITH, J. K.; GERSTL, B.; DAVIS, W. E.; ORTH, D. L. - Lipoprotein patterns of spinal fluid obtained by paper electrophoresis. Arch. Neurol, a. Psychiat., 76:608 (dezembro), 1956.

[66] 66. SOMMERFELT, S. C. - Reproducibility with paper electrophoresis of serum proteins. Scandinav. J. Clin. a. Laborat. Invest., 4:307, 1952.

[67] 67. SOMMERFELT, S. C. - Some practical points regarding the reading of the paper electrophoretic strip. Symposium on Paper Electrophoresis, J. & A. Churchill Ltd., Londres, 1956, págs. 151-159.

[68] 68. STEGER, J. - Elektrophoretische Untersuchungen des Liquors. Dtsch. Z. f. Nervenheilk., 171:1 (novembro), 1953.

[69] 69. TISELIUS, A. - Electrophoresis of serum globulin. Electrophoresis analysis of normal and immune sera. Biochem. J., 31:1464, 1937.

[70] 70. TONINI, G.; INESI, G.; RISIO, C. de - Considerazione tecniche e metodologiche in campo di elettroforesi delle proteine liquorali. G. di Psiquiat. e di Neuropatol., 85:203, 1957.

[71] 71. VYMAZAL, J.; HOVORKOVÁ, B. - A contribution to the theory of the colloidal gold reaction. Ceskolovenská Neurologie, 19:207 (setembro), 1956.

[72] 72. WALLENIUS, G. - Electrophoretic patterns of cerebrospinal fluid and serum compared in normal and pathological conditions. Acta Societ. Med. Upsalliensis, 57:138 (junho, 20), 1952.

Brasil

Brasil

Eletroforese das proteínas do líqüido cefalorraquidiano I: considerações gerais sôbre a eletroforese em papel

Electrophoresis of cerebrospinal fluid proteins: general considerations on paper electrophoresis

Resumos

Datas de Publicação