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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.18 no.3 São Paulo Sept. 1960

http://dx.doi.org/10.1590/S0004-282X1960000300004 

Fronteiras na investigação da esquizofrenia

 

Schizophrenia: advances in research

 

 

Marcelo Blaya

Ex-interno do Michael Reese Hospital (Chicago, Illinois); ex-fellow da Menninger School of Psychiatry (Topeka, Kansas); ex-residente em Psiquiatria do Topeka State Hospital e do Larned State Hospital; Diretor da Clínica Pinel (Pôrto Alegre, Rio Grande do Sul)

 

 


RESUMO

O conceito bleuleriano de esquizofrenia continua a ser o mais acatado pelos investigadores. Apesar da existência de correntes nitidamente biológicas ou psicológicas nota-se, nos trabalhos de pesquisa, uma tendência marcadamente psicobiológica. No presente trabalho são discutidos os resultados obtidos por três grupos de investigadores, um operando com variáveis biológicas, e os outros dois, com variáveis de relação interpessoal, especialmente infrafamiliares.
O primeiro grupo é liderado por Heath que tem chamado a atenção para a atividade bioelétrica anormal de certas estruturas subcorticais (região septal e hipocampo) em relação às variações posturais e de conduta, tanto em macacos como em sêres humanos. O isolamento de uma proteína específica no sôro de pacientes esquizofrênicos, capaz de produzir sintomas em voluntários injetados com esse material, parece mostrar que existe uma falha metabólica, possivelmente enzimática, nesses pacientes.
Os outros dois grupos, liderados por Bowen e Lidz, estudam características das funções e interrelações em famílias com pacientes esquizofrênicos. As conclusões de ambos os grupos apoia o conceito de famílias esquizofrênicas contra o ponto de vista clássico de pacientes esquizofrênicos.


SUMMARY

Bleuler's concept of schizophrenia is up till now the most widely accepted by the investigators. In spite of trends of research clearly biological or psychological, there is a tendency for a clear cut psychobiological approach or, even better, for a multidisciplinary study of the problem. In this paper are discussed the results obtained by three groups of researchers. One deals with biological variables while the other two work with interpersonal relations, mostly intrafamilial ones.
The first is the Tulane group. Heath, in charge of the project, has stressed that abnormal bioelectrical activity of certain subcortical areas, mainly the septal region and the hippocampus, is related to postural and behavioral variations in monkeys and humans. The isolation of a protein from the serum of schizophrenic patients, that produces schizophrenic-like symptoms in voluntaries when injected with this substance, tries to prove the existence of a metabolic error, probably enzymatic, in these patients.
The other two groups (Bethesda and Yale), with Bowen and Lidz, are studying characteristics of the functions and interrelations in families with one schizophrenic patient mainly adolescent. The conclusions arrived by both groups of researchers support the concept of a schizophrenic family vs. the classical concept of a schizophrenic patient.


 

 

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Parte dêste trabalho foi apresentado à Sociedade de Neurologia, Psiquiatria e Neurocirurgia do Rio Grande do Sul
Clínica Pinel - Av. João Pessoa, 943 - Pôrto Alegre - Rio Grande do Sul.

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