Resumos
A administração oral de 15, 30 e 60 mg/kg de l-hexil-3,7-dimetilxantina produziu, em cães, dilatação dos vasos piais sem ocasionar hipotensão arterial.
The authors studied the action of the l-hexyl-3,7-dimethylxanthine on the blood pressure and on the caliber of the pial vessels of the dog. In 15 dogs anesthetized by sodium penthobarbital (30 mg/kg) the arterial blood pressure was recorded with a mercury manometer. The pial vessels were observed through a window made in the temporal bone with the aid of binocular stereoscopic microscope. For photography one of the oculars of the microscope was replaced by an appropriate camera. The procedure was that proposed by Forbes4 modified by Melaragno5. Groups of 4 animals received respectively 15, 30 and 60 mg/kg of the drug by the oral route and were observed until 240 minutes. The other three animals were used as control and observed by the same interval of time, receiving only the anesthetic. The oral administration of the l-hexyl-3,7-dimethylxanthine induced marked relaxation of the pial vessels without concomitant fall of the arterial blood pressure, in spite of the doses of 15 mg/kg.
Armando Octavio Ramos I; Octavio SlemerII; Pedro Carlos Bissetti II; Sylvio Saraiva III; Laone Ramos I
IAssistentes ; Trabalho do Departamento de Farmacologia (Prof. C. E. Corbett) e da Clínica Neurológica (Prof. Adherbal Tolosa) da Fac. Med. da Univ. de São Paulo
IITécnicos do Departamento de Farmacologia; Trabalho do Departamento de Farmacologia (Prof. C. E. Corbett) e da Clínica Neurológica (Prof. Adherbal Tolosa) da Fac. Med. da Univ. de São Paulo
IIIMédico-assistente da Clínica Neurológica; Trabalho do Departamento de Farmacologia (Prof. C. E. Corbett) e da Clínica Neurológica (Prof. Adherbal Tolosa) da Fac. Med. da Univ. de São Paulo
RESUMO
A administração oral de 15, 30 e 60 mg/kg de l-hexil-3,7-dimetilxantina produziu, em cães, dilatação dos vasos piais sem ocasionar hipotensão arterial.
SUMMARY
The authors studied the action of the l-hexyl-3,7-dimethylxanthine on the blood pressure and on the caliber of the pial vessels of the dog.
In 15 dogs anesthetized by sodium penthobarbital (30 mg/kg) the arterial blood pressure was recorded with a mercury manometer. The pial vessels were observed through a window made in the temporal bone with the aid of binocular stereoscopic microscope. For photography one of the oculars of the microscope was replaced by an appropriate camera. The procedure was that proposed by Forbes4 modified by Melaragno5. Groups of 4 animals received respectively 15, 30 and 60 mg/kg of the drug by the oral route and were observed until 240 minutes. The other three animals were used as control and observed by the same interval of time, receiving only the anesthetic.
The oral administration of the l-hexyl-3,7-dimethylxanthine induced marked relaxation of the pial vessels without concomitant fall of the arterial blood pressure, in spite of the doses of 15 mg/kg.
Texto completo disponível apenas em PDF.
Full text available only in PDF format.
Departamento de Farmacologia - Fac. Med. da Univ. de São Paulo - Caixa Postal 2921 -• São Paulo, Brasil
- 1. CUGURRA, F. & ECHINARD-GARIN, P. - Alcuni aspetti delia attività farmacologica di nuovo teofilinico: exil-3,7-dimetilxantina (SK7). Arch. Internat. Phar-macodyn., 123:481-489, 1960.
- 2. FINESINGER, J. E. - Cerebral circulation: effect of caffeine on cerebral vessels. Arch. Neurol, a. Psychiat., 28:1290-1325, 1932.
- 3. FINESINGER, J. E. & COBB, S. - Cerebral circulation: action on the pial arteries of the convulsants caffeine, absinth, camphor and picrotoxin. Arch. Neurol, a. Psychiat., 30:980-1002, 1933.
- 4. FORBES, H. S. - The cerebral circulation: observation and measurement of pial vessels. Arch. Neurol, a. Psychiat., 19:751-761, 1928.
- 5. MELARAGNO, R. (filho) - Farmacologia da circulação cerebral: contribuição experimental. Tese de docência. Faculdade de Medicina da Universidade de São Paulo, 1954.
- 6. NOELL, W. - über die Wirkung des Theophyllins und der verschiedenen Löseungsvermittler auf die Gehirndurchblutung. Ztschr. f. d. ges. exper. Med., 110:589-600, 1942.
- 7. QUEVAUVILLER, A. - Pharmacodynamic de la théophylline et de ses derives. Actual. Pharmacol., 8:107-152, 1955.
- 8. WECHSLER, R. L.; KLEIS, L. M. & KETY, S. S. - The effect of intravenously administered aminophylline on cerebral circulation and metabolism in man. J. Clin. Invest., 29:28-30, 1950.
Atividade dilatadora da l-hexil-3,7-dimetilxantina sôbre os vasos piais
Datas de Publicação
-
Publicação nesta coleção
21 Ago 2013 -
Data do Fascículo
Mar 1963
