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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.23 no.4 São Paulo Dec. 1965

http://dx.doi.org/10.1590/S0004-282X1965000400002 

Vitamin B12 in the pathogenesis of subacute combined degeneration of the spinal cord

 

Papel da vitamina B12 na patogenia da mielose funicular

 

 

Horacio M. CanelasI; Nelson de CarvalhoII; Arnaldo Gama da RochaI

I(Prof. Adherbal Tolosa) and the Center of Nuclear Medicine; From the Department of Neurology of the Medical School
II(Dr. Tede Eston) of the University of São Paulo, Brazil; From the Department of Neurology of the Medical School

 

 


ABSTRACT

The absorption of labeled vitamin B12 in 29 cases of subacute combined degeneration of the spinal cord was studied. The diagnosis was based on the classical neurologic picture and on the presence of gastric achlorhydria and eventual blood or bone marrow changes. The neurologic manifestations were evaluated in a semiquantitative way and were correlated to the results of the urinary excretion test of vitamin B12.
The absorption of vitamin B12 was not significantly correlated to the neurologic picture as a whole, or to the peripheral and dorsal funiculi syndromes. However, a significant negative correlation was found between the pyramidal syndrome and the absorption of vitamin B12.
The results are confronted with the significance of vitamin B12 in the synthesis of myelin sheaths and ribonucleic acid, the essential role of RNA for the life of the nerve cells and the long axons being emphasized.


RESUMO

Foi estudada a absorção da vitamina B12 radioativa em 29 casos de mielose funicular. O diagnóstico baseou-se na clássica sintomatologia neu- rológica e na presença de acloridria gástrica e eventuais alterações hemato-lógicas. As manifestações neurológicas foram avaliadas de modo semiquan-titativo e correlacionadas com os resultados do teste de excreção urinária da vitamina B12.
Não foi verificada correlação significante da absorção da vitamina B12, quer com a sintomatologia nuerológica total, quer com as síndromes periférica e funicular dorsal. Contudo, foi encontrada significante correlação negativa entre a síndrome piramidal e a absorção da vitamina B12.
Os resultados são confrontados com o papel desempenhado pela vitamina B12 na síntese das bainhas de mielina e do ácido ribonuclêico, sendo salientada a importância dêste último para a vida das células nervosas e dos longos axônios.


 

 

Full text available only in PDF format.

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