Metabolism of fat in subacute combined degeneration of the spinal cord

Canelas, Horacio M.; Carvalho, Nelson de; Rocha, Arnaldo Gama da

doi:10.1590/S0004-282X1966000100001

Abstracts

In 10 cases of subacute combined degeneration of the spinal cord the absorption, clearance and utilization of labeled fat was studied. In 4 cases disorders of the lipid metabolism were found. Although not significantly, the peripheral and dorsal funiculi syndromes were more severe in the 4 cases with impaired fat metabolism than in the normal cases, while the pyramidal syndrome was almost the same in the two groups. The whole neurological picture was also more severe in the 4 cases with disorders of fat metabolism. These results seem to indicate that the impairment of lipid metabolism evidenced in such cases bears no direct relationship with the demyelinating process in general, and would rather attend a deficiency of metabolites (probably B-complex vitamins) other than vitamin B12, which play a more significant role in the preservation of the peripheral nerves.

Em 10 casos de mielose funicular foram estudadas a absorção, a depuração e a utilização de lípides radioativos. Em 4 dêsses casos foram verificadas alterações do metabolismo lipídico. Embora não significantemente, as síndromes periférica e funicular dorsal mostraram-se mais intensas nos 4 casos com distúrbios do metabolismo lipídico que nos demais, enquanto a síndrome piramidal foi aproximadamente semelhante nos dois grupos de pacientes. A sintomatologia neurológica global também se apresentou mais intensa nos 4 casos com alterações do metabolismo lipídico. Estes resultados parecem indicar que as alterações do metabolismo das gorduras demonstradas nesses casos não se vinculam diretamente ao processo desmielinizante em geral, parecendo antes refletir uma carência de metabólitos (provavelmente vitaminas do complexo B) diversos da vitamina B12, que desempenhariam papel mais importante na preservação dos nervos periféricos.

Horacio M. Canelas^I; Nelson de Carvalho^II; Arnaldo Gama da Rocha^I

^IDepartment of Neurology and the Center of Nuclear Medicine

^IIUniversity of São Paulo School of Medicine, Brazil

ABSTRACT

In 10 cases of subacute combined degeneration of the spinal cord the absorption, clearance and utilization of labeled fat was studied. In 4 cases disorders of the lipid metabolism were found.

Although not significantly, the peripheral and dorsal funiculi syndromes were more severe in the 4 cases with impaired fat metabolism than in the normal cases, while the pyramidal syndrome was almost the same in the two groups. The whole neurological picture was also more severe in the 4 cases with disorders of fat metabolism.

These results seem to indicate that the impairment of lipid metabolism evidenced in such cases bears no direct relationship with the demyelinating process in general, and would rather attend a deficiency of metabolites (probably B-complex vitamins) other than vitamin B₁₂, which play a more significant role in the preservation of the peripheral nerves.

ABSTRACT

Em 10 casos de mielose funicular foram estudadas a absorção, a depuração e a utilização de lípides radioativos. Em 4 dêsses casos foram verificadas alterações do metabolismo lipídico.

Embora não significantemente, as síndromes periférica e funicular dorsal mostraram-se mais intensas nos 4 casos com distúrbios do metabolismo lipídico que nos demais, enquanto a síndrome piramidal foi aproximadamente semelhante nos dois grupos de pacientes. A sintomatologia neurológica global também se apresentou mais intensa nos 4 casos com alterações do metabolismo lipídico.

Estes resultados parecem indicar que as alterações do metabolismo das gorduras demonstradas nesses casos não se vinculam diretamente ao processo desmielinizante em geral, parecendo antes refletir uma carência de metabólitos (provavelmente vitaminas do complexo B) diversos da vitamina B₁₂, que desempenhariam papel mais importante na preservação dos nervos periféricos.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

REFERENCES

1. ADAMS, C. W. M. - The histochemistry of the myelin sheath. In K. A. C. Elliot, I. H. Page & J. H. Quastel: Neurochemistr'y, 2nd. edition. Charles C. Thomas, Springfield, 1962, pp. 85-122.

2. AUTILIO, L. A.; NORTON, W. T. & TERRY, R. D - The preparation and some properties of purified myelin from the central nervous system. J. Neurochem. 11:12-27, 1964.

3. BAKER, R. W. R.; THOMPSON, R. H. S. & ZILKHA, K. J. - Serum fatty acids in multiple sclerosis. J. Neurol. Neurosurg. Psychiat. 27:408-414, 1964.

4. BERNSOHN, J. & NAMAJUSKA, I. - Phospholipid fractions in multiple sclerosis and normal serum. Proc. Soc. exp. Biol. (N.Y.), 88: 124-127, 1955.

5. CANELAS, H. M. - Lipóides e fósforo inorgânico humorais na neuranemia. Arq. Neuro-psiquiat. (S. Paulo) 8:249-256, 1950.

6. CANELAS, H. M. - Quantificação clínica da sintomatologia neurológica. Rev. paul. Med. 63:178-184, 1963.

7. CANELAS, H. M.; TEIXEIRA-PINTO, J. & SHNAIDER, J. - Absorção da vitamina B₁₂ nas mieloses funiculares. Arq. Neuro-psiquiat. (S. Paulo), 19:1-10, 1961.

8. CANELAS, H. M.; CARVALHO, N. & ROCHA, A. G. - On the role of vitamin B₁₂ in the pathogenesis of subacute combined degeneration of the spinal cord. Arq. Neuro-psiquiat. (S. Paulo), 23:253-260, 1965.

9. CARREGA, D.; BRAGE, D. & RIVAS, L. - La lipidorraquia en las anemias perniciosas. Sem. méd. (B. Aires), 55:403-408, 1948.

10. CUMINGS, J. N. - Abnormalities of lipid chemistry in cerebral lipidoses and demyelinating conditions. In J. N. Cumings: Modern Scientific Aspects of Neurology. Arnold, London, 1960, pp. 330-354.

11. GERSTL, B.; DAVIS, W. E.; SMITH, J. K.; RAMORINO, P. M. & ORTH, D. - Serum lipids in patients with multiple sclerosis. Amer. J. clin. Path. 27:315-320, 1957.

12. GREEN, J. B.; PAPA-DOPOULOS, N.; CEVALLOS, W.; FOERSTER, F. M. & HESS, W. C. - The cholesterol and cholesterol ester content of cerebrospinal fluid in patients with multiple sclerosis and other neurological diseases. J. Neurol. Neurosurg. Psychiat. 22:117-119, 1954.

13. HILLS, C. P. & SPECTOR, R. G. - The nerve cell. Development. Med. Child. Neurol., suppl. 8, 1964.

14. LAFONTAINE, A. - Les phospholipides humoraux au cours de certaines affections nerveuses. J. beige Neurol. Psychiat. 44/46:344-348, 1946.

15. LAFONTAINE, A. - À propos des lipides humoraux autres que les phosphatides totaux dans certaines affections neurologiques. J. beige Neurol. Psychiat. 47:199-210, 1947.

16. MIETTINEN, M. - Studies of serum lipids and lipoprotein in some anaemias. Ann. Med. intern, fenn., vol. 45, suppl. 22, pp. 1-92, 1956.

17. MULLER, G. L. - The relation of cholesterol, lecithin phosphorus and fatty acids to the remission of pernicious anemia. Amer. J. med. Sci. 179:315-337, 1930.

18. NEILL, D. W. & WEAVER, J. A. - A study of some metabolic processes dependent on coenzyme A in pernicious anemia. Acta haematol. (Basel), 21:23-30, 1959. 19. PALVA, I. P. - Serum cholesterol level in vitamin B₁₂ deficiency of fish tapeworm carriers. Ann. Med. intern, fenn. 52:195-198, 1962.

20. PLUM, C. M. & FOG, T. - Studies in multiple sclerosis (I). Acta psychiat. neurol. scand., vol. 34, suppl. 128, 1959.

21. SCHILLING, R. F. - Intrinsic factor studies. II: The effect of gastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B₁₂. J. Lab. clin. Med. 42:860-866, 1953.

22. SERCL, M.; KOVARICK, J. & JILCHA, J. - Étude des valeurs des lipides du sérum sanguin en cas de sclérose en plaques. Acta neurol. scand. 37:317-324, 1961.

23. SMITH, M. E. - Lipid biosynthesis in the central nervous system in experimental allergic encephalomyelitis. J. Neurochem. 11:29-37, 1964.

24. SPERRY, W. M. & WAELSCH, R. - The chemistry of myelination and demyelination. Res. Publ. Ass. nerv. ment. Dis. 28:255-267, 1950.

25. SPILLANE, J. D. & WELLS, C. E. C. - Nutritional disorders of the central nervous system. In K. A. C. Elliott, I. H. Page & J. H. Quastel: Neurochemistry, 2nd. edition. Charles C. Thomas, Springfield, 1962, pp. 930-953.

Read at the First International Symposium on Nuclear Biology and Medicine, held in São Paulo, Brazil, September 20-25, 1964.

Department of Neurology - University of São Paulo School of Medicine - Caixa Postal 3461 - São Paulo, SP - Brasil

1. ADAMS, C. W. M. - The histochemistry of the myelin sheath. In K. A. C. Elliot, I. H. Page & J. H. Quastel: Neurochemistr'y, 2nd. edition. Charles C. Thomas, Springfield, 1962, pp. 85-122.
2. AUTILIO, L. A.; NORTON, W. T. & TERRY, R. D - The preparation and some properties of purified myelin from the central nervous system. J. Neurochem. 11:12-27, 1964.
3. BAKER, R. W. R.; THOMPSON, R. H. S. & ZILKHA, K. J. - Serum fatty acids in multiple sclerosis. J. Neurol. Neurosurg. Psychiat. 27:408-414, 1964.
4. BERNSOHN, J. & NAMAJUSKA, I. - Phospholipid fractions in multiple sclerosis and normal serum. Proc. Soc. exp. Biol. (N.Y.), 88: 124-127, 1955.
5. CANELAS, H. M. - Lipóides e fósforo inorgânico humorais na neuranemia. Arq. Neuro-psiquiat. (S. Paulo) 8:249-256, 1950.
6. CANELAS, H. M. - Quantificação clínica da sintomatologia neurológica. Rev. paul. Med. 63:178-184, 1963.
7. CANELAS, H. M.; TEIXEIRA-PINTO, J. & SHNAIDER, J. - Absorção da vitamina B₁₂ nas mieloses funiculares. Arq. Neuro-psiquiat. (S. Paulo), 19:1-10, 1961.
8. CANELAS, H. M.; CARVALHO, N. & ROCHA, A. G. - On the role of vitamin B₁₂ in the pathogenesis of subacute combined degeneration of the spinal cord. Arq. Neuro-psiquiat. (S. Paulo), 23:253-260, 1965.
9. CARREGA, D.; BRAGE, D. & RIVAS, L. - La lipidorraquia en las anemias perniciosas. Sem. méd. (B. Aires), 55:403-408, 1948.
10. CUMINGS, J. N. - Abnormalities of lipid chemistry in cerebral lipidoses and demyelinating conditions. In J. N. Cumings: Modern Scientific Aspects of Neurology. Arnold, London, 1960, pp. 330-354.
11. GERSTL, B.; DAVIS, W. E.; SMITH, J. K.; RAMORINO, P. M. & ORTH, D. - Serum lipids in patients with multiple sclerosis. Amer. J. clin. Path. 27:315-320, 1957.
12. GREEN, J. B.; PAPA-DOPOULOS, N.; CEVALLOS, W.; FOERSTER, F. M. & HESS, W. C. - The cholesterol and cholesterol ester content of cerebrospinal fluid in patients with multiple sclerosis and other neurological diseases. J. Neurol. Neurosurg. Psychiat. 22:117-119, 1954.
13. HILLS, C. P. & SPECTOR, R. G. - The nerve cell. Development. Med. Child. Neurol., suppl. 8, 1964.
14. LAFONTAINE, A. - Les phospholipides humoraux au cours de certaines affections nerveuses. J. beige Neurol. Psychiat. 44/46:344-348, 1946.
15. LAFONTAINE, A. - À propos des lipides humoraux autres que les phosphatides totaux dans certaines affections neurologiques. J. beige Neurol. Psychiat. 47:199-210, 1947.
16. MIETTINEN, M. - Studies of serum lipids and lipoprotein in some anaemias. Ann. Med. intern, fenn., vol. 45, suppl. 22, pp. 1-92, 1956.
17. MULLER, G. L. - The relation of cholesterol, lecithin phosphorus and fatty acids to the remission of pernicious anemia. Amer. J. med. Sci. 179:315-337, 1930.
18. NEILL, D. W. & WEAVER, J. A. - A study of some metabolic processes dependent on coenzyme A in pernicious anemia. Acta haematol. (Basel), 21:23-30, 1959.
19. PALVA, I. P. - Serum cholesterol level in vitamin B₁₂ deficiency of fish tapeworm carriers. Ann. Med. intern, fenn. 52:195-198, 1962.
20. PLUM, C. M. & FOG, T. - Studies in multiple sclerosis (I). Acta psychiat. neurol. scand., vol. 34, suppl. 128, 1959.
21. SCHILLING, R. F. - Intrinsic factor studies. II: The effect of gastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B₁₂ J. Lab. clin. Med. 42:860-866, 1953.
22. SERCL, M.; KOVARICK, J. & JILCHA, J. - Étude des valeurs des lipides du sérum sanguin en cas de sclérose en plaques. Acta neurol. scand. 37:317-324, 1961.
23. SMITH, M. E. - Lipid biosynthesis in the central nervous system in experimental allergic encephalomyelitis. J. Neurochem. 11:29-37, 1964.
24. SPERRY, W. M. & WAELSCH, R. - The chemistry of myelination and demyelination. Res. Publ. Ass. nerv. ment. Dis. 28:255-267, 1950.
25. SPILLANE, J. D. & WELLS, C. E. C. - Nutritional disorders of the central nervous system. In K. A. C. Elliott, I. H. Page & J. H. Quastel: Neurochemistry, 2nd. edition. Charles C. Thomas, Springfield, 1962, pp. 930-953.

Metabolism of fat in subacute combined degeneration of the spinal cord

Metabolismo dos lípides na mielose funicular

Publication Dates

Publication in this collection
14 Aug 2013
Date of issue
Mar 1966

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. ADAMS, C. W. M. - The histochemistry of the myelin sheath. In K. A. C. Elliot, I. H. Page & J. H. Quastel: Neurochemistr'y, 2nd. edition. Charles C. Thomas, Springfield, 1962, pp. 85-122.

[2] 2. AUTILIO, L. A.; NORTON, W. T. & TERRY, R. D - The preparation and some properties of purified myelin from the central nervous system. J. Neurochem. 11:12-27, 1964.

[3] 3. BAKER, R. W. R.; THOMPSON, R. H. S. & ZILKHA, K. J. - Serum fatty acids in multiple sclerosis. J. Neurol. Neurosurg. Psychiat. 27:408-414, 1964.

[4] 4. BERNSOHN, J. & NAMAJUSKA, I. - Phospholipid fractions in multiple sclerosis and normal serum. Proc. Soc. exp. Biol. (N.Y.), 88: 124-127, 1955.

[5] 5. CANELAS, H. M. - Lipóides e fósforo inorgânico humorais na neuranemia. Arq. Neuro-psiquiat. (S. Paulo) 8:249-256, 1950.

[6] 6. CANELAS, H. M. - Quantificação clínica da sintomatologia neurológica. Rev. paul. Med. 63:178-184, 1963.

[7] 7. CANELAS, H. M.; TEIXEIRA-PINTO, J. & SHNAIDER, J. - Absorção da vitamina B₁₂ nas mieloses funiculares. Arq. Neuro-psiquiat. (S. Paulo), 19:1-10, 1961.

[8] 8. CANELAS, H. M.; CARVALHO, N. & ROCHA, A. G. - On the role of vitamin B₁₂ in the pathogenesis of subacute combined degeneration of the spinal cord. Arq. Neuro-psiquiat. (S. Paulo), 23:253-260, 1965.

[9] 9. CARREGA, D.; BRAGE, D. & RIVAS, L. - La lipidorraquia en las anemias perniciosas. Sem. méd. (B. Aires), 55:403-408, 1948.

[10] 10. CUMINGS, J. N. - Abnormalities of lipid chemistry in cerebral lipidoses and demyelinating conditions. In J. N. Cumings: Modern Scientific Aspects of Neurology. Arnold, London, 1960, pp. 330-354.

[11] 11. GERSTL, B.; DAVIS, W. E.; SMITH, J. K.; RAMORINO, P. M. & ORTH, D. - Serum lipids in patients with multiple sclerosis. Amer. J. clin. Path. 27:315-320, 1957.

[12] 12. GREEN, J. B.; PAPA-DOPOULOS, N.; CEVALLOS, W.; FOERSTER, F. M. & HESS, W. C. - The cholesterol and cholesterol ester content of cerebrospinal fluid in patients with multiple sclerosis and other neurological diseases. J. Neurol. Neurosurg. Psychiat. 22:117-119, 1954.

[13] 13. HILLS, C. P. & SPECTOR, R. G. - The nerve cell. Development. Med. Child. Neurol., suppl. 8, 1964.

[14] 14. LAFONTAINE, A. - Les phospholipides humoraux au cours de certaines affections nerveuses. J. beige Neurol. Psychiat. 44/46:344-348, 1946.

[15] 15. LAFONTAINE, A. - À propos des lipides humoraux autres que les phosphatides totaux dans certaines affections neurologiques. J. beige Neurol. Psychiat. 47:199-210, 1947.

[16] 16. MIETTINEN, M. - Studies of serum lipids and lipoprotein in some anaemias. Ann. Med. intern, fenn., vol. 45, suppl. 22, pp. 1-92, 1956.

[17] 17. MULLER, G. L. - The relation of cholesterol, lecithin phosphorus and fatty acids to the remission of pernicious anemia. Amer. J. med. Sci. 179:315-337, 1930.

[18] 18. NEILL, D. W. & WEAVER, J. A. - A study of some metabolic processes dependent on coenzyme A in pernicious anemia. Acta haematol. (Basel), 21:23-30, 1959.

[19] 19. PALVA, I. P. - Serum cholesterol level in vitamin B₁₂ deficiency of fish tapeworm carriers. Ann. Med. intern, fenn. 52:195-198, 1962.

[20] 20. PLUM, C. M. & FOG, T. - Studies in multiple sclerosis (I). Acta psychiat. neurol. scand., vol. 34, suppl. 128, 1959.

[21] 21. SCHILLING, R. F. - Intrinsic factor studies. II: The effect of gastric juice on the urinary excretion of radioactivity after the oral administration of radioactive vitamin B₁₂ J. Lab. clin. Med. 42:860-866, 1953.

[22] 22. SERCL, M.; KOVARICK, J. & JILCHA, J. - Étude des valeurs des lipides du sérum sanguin en cas de sclérose en plaques. Acta neurol. scand. 37:317-324, 1961.

[23] 23. SMITH, M. E. - Lipid biosynthesis in the central nervous system in experimental allergic encephalomyelitis. J. Neurochem. 11:29-37, 1964.

[24] 24. SPERRY, W. M. & WAELSCH, R. - The chemistry of myelination and demyelination. Res. Publ. Ass. nerv. ment. Dis. 28:255-267, 1950.

[25] 25. SPILLANE, J. D. & WELLS, C. E. C. - Nutritional disorders of the central nervous system. In K. A. C. Elliott, I. H. Page & J. H. Quastel: Neurochemistry, 2nd. edition. Charles C. Thomas, Springfield, 1962, pp. 930-953.