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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.26 no.1 São Paulo Mar. 1968

https://doi.org/10.1590/S0004-282X1968000100008 

Necrose medular maciça após vacinação antirrábica

 

Massive necrosis of the spinal cord after anti-rabic vaccination

 

 

José Paulo Carvalhal

Professor adjunto de Anatomia (Regente de Neuranatomia) na Faculdade de Medicina da Universidade Federal do Rio de Janeiro; Consultor de Neurologia do Isolamento Francisco de Castro (Rio de Janeiro, GB)

 

 


RESUMO

Descrição de um caso de necrose maciça da medula espinhal por vacinação antirrábica. A doença caracterizou-se por paralisia de tipo ascendente e hipertermia. As investigações histológicas revelaram, na medula espinhal, extensas áreas de necrose, hemorragias, zonas de desmielinização, infiltrados linfocitários, além de infiltrados linfocitários no bulbo e nas meninges. A neuralergia explicaria o mecanismo patogênico e a distribuição da rede arterial condicionaria a topografia das lesões.


SUMMARY

Acase of acute necrosis of the spinal cord after antirabic vaccination s reported. The clinical course was characterized by Landry's ascending jaralysis and hyperthermia. The histopathological examination showed exensive necrotic areas, demyelinated zone, haemorragic and lymphocytic nfiltrates in the spinal cord; in the medulla and meninges there were ymphocytic infitrates. Neuroallergy would explain the pathogenic mechalism and the arterial distribution the lesion's topography.


 

 

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Rua Sambaiba 63. Leblon — Rio de Janeiro, GB — Brasil.
Nota do autor — Agradeço a colaboração dos médicos do Hospital Central da Marinha, ressaltando o auxílio dos Drs. Carlos Murta e Silva Araújo.

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