SciELO - Scientific Electronic Library Online

 
vol.34 issue1Cerebrospinal fluid immunoglobulins in cysticercosis of the central nervous systemInflamatory chronic processes of the central nervous system: neurosurgical aspects author indexsubject indexarticles search
Home Pagealphabetic serial listing  

Services on Demand

Journal

Article

Indicators

Related links

Share


Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.34 no.1 São Paulo Mar. 1976

http://dx.doi.org/10.1590/S0004-282X1976000100005 

Copper and ceruloplasmin contents in the blood serum of peripheral and pre-hepatic veins

 

Concentrações de cobre e ceruloplasmina no soro sanguíneo de veias periférica e pré-hepática

 

 

H. M. Canelas; I. Roitman; M. Scaff; S. Raia; F. B. De Jorge

Departments of Neuropsychiatry (Division of Neurology) and Surgery (3rd Division) of the University of São Paulo Medical School

 

 


SUMMARY

Copper and ceruloplasmin contents were determined in samples of peripheral and pre-hepatic venous blood of 11 patients with Manson's schistosomiasis and one patient with hepatolenticular degeneration, all of çhich submitted either to porto-caval or spleno-renal shunt. Individual difference were not significant in any of the non-Wilsonian patients. The results are discussed in regard to the current knowledge on the pathogenesis of Wilson's disease.


RESUMO

Foram determinadas as concentrações de cobre e ceruloplasmina em amostras de sangue venoso periférico e pré-hepático de 11 pacientes esquistossomóticos e de 1 paciente com degeneração hepatolenticular, submetidos a anastomose portocava ou esplenorrenal. Nos 11 pacientes não wilsonianos, as diferenças individuais não se revelaram estatisticamente significantes. Os resultados são comentados em relação aos conhecimentos atuais sobre a patogenia da moléstia de Wilson.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

REFERENCES

1. BERNSTEIN, L. & WEATHERALL, M. — Statistics for Medical and other Biological Students. Livingstone, Edinburgh, 1952, pp. 85-88.         [ Links ]

2. DE JORGE, F. B. & CANELAS, H. M. — Contribuição ao estudo da ceruloplasmina: valores normais no soro sanguíneo. Arq. Neuro-Psiquiat (São Paulo) 22:271, 1964.         [ Links ]

3. DE JORGE, F. B.; CANELAS, H. M. & COSTA-SILVA, A. — Contribuição ao estudo do metabolismo do cobre: metodologia da determinação do cobre em materiais biológicos. Rev. paul. Med. 61:350, 1962.         [ Links ]

4. DE JORGE, F. B.; CANELAS, H. M. & SPINA-FRANÇA, A. — Contribuição ao estudo do metabolismo do cobre: valores normais no sangue, liquido cefalorraqueano e urina. Rev. paul. Med. 62:125, 1963.         [ Links ]

5. FROMMER, D. J. — Defective biliary excretion of copper in Wilson's disease. Gut 15:125, 1974.         [ Links ]

6. GOLDSTEIN, W. P. & OWEN, C. A. — Introduction. Symposium of copper metabolism and Wilson's disease. Mayo Clin. Proc. 49:363, 1974.         [ Links ]

7. HOUCHIN, O. B. — A rapid colorimetric method for the quantitative determination of copper oxidase activity (ceruloplasmin). Clin. Chem. 4:519, 1958.         [ Links ]

8. O'REILLY, S. — Problems in Wilson's disease. Neurology (Minneapolis) 17: 137, 1967.         [ Links ]

9. O'REILLY, S.; POLLYCOVE, M.; TONO, M. & HERRADORA, L. — Abnormalities of the physiology of copper in Wilson's disease: the internal kinetics of copper. Arch. Neurol. (Chicago) 24:481, 1971.         [ Links ]

10. O'REILLY, S.; WEBER, P. M.; OSWALD, M. & SHIPLEY, L. — Abnormalities of the physiology of copper in Wilson's disease: the excretion of copper. Arch. Neurol. (Chicago) 25:28, 1971.         [ Links ]

11. OSBORN, S. & WALSHE, J. M. — Copper uptake by the liver: study of a Wilson's disease family. In J. M. Walshe & J. N. Cumings — Wilson's Disease, Some Current Concepts. Blackwell, Oxford, 1961, p. 141.         [ Links ]

12. SASS-KORTSAK, A.; CHERNIAK, M.; GEIGER, D. W. & SLATER, R. J. — Observations on ceruloplasmin in Wilson's disease. J. clin. Invest. 38:1672, 1959.         [ Links ]

13. SCHEINBERG, I. H. & MORELL, A. G. — Ceruloplasmin. In G. Eichhorn — Inorganic Biochemistry. Elsevier, Amsterdam, 173, vol. 1, chapter 10, p. 306.         [ Links ]

14. TRIP, J. A. J. — Ceruloplasmin: Clinical and Experimental Investigations on Origin, Presence and Behavior of Fractions. Wolters-Noorhoff, Groningen, 1968.         [ Links ]

15. WALSHE, J. M. — The physiology of copper in man and its relation to Wilson's disease. Brain 90:149, 1967.         [ Links ]

16. ZIMDAHL, W. T.; HYMAN, I. & COOK, E. D. — Metabolism of copper in hepatolenticular degeneration. Neurology (Minneapolis) 3:569, 1953.         [ Links ]

 

 

Departamento de Neuropsiquiatria, Divisão de Neurologia — Faculdade de Medicina, Universidade ãe São Paulo — Caixa Postal 3461 — 01000 São Paulo, SP — Brasil.

Creative Commons License All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License