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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.34 no.1 São Paulo Mar. 1976 

Copper and ceruloplasmin contents in the blood serum of peripheral and pre-hepatic veins


Concentrações de cobre e ceruloplasmina no soro sanguíneo de veias periférica e pré-hepática



H. M. Canelas; I. Roitman; M. Scaff; S. Raia; F. B. De Jorge

Departments of Neuropsychiatry (Division of Neurology) and Surgery (3rd Division) of the University of São Paulo Medical School




Copper and ceruloplasmin contents were determined in samples of peripheral and pre-hepatic venous blood of 11 patients with Manson's schistosomiasis and one patient with hepatolenticular degeneration, all of çhich submitted either to porto-caval or spleno-renal shunt. Individual difference were not significant in any of the non-Wilsonian patients. The results are discussed in regard to the current knowledge on the pathogenesis of Wilson's disease.


Foram determinadas as concentrações de cobre e ceruloplasmina em amostras de sangue venoso periférico e pré-hepático de 11 pacientes esquistossomóticos e de 1 paciente com degeneração hepatolenticular, submetidos a anastomose portocava ou esplenorrenal. Nos 11 pacientes não wilsonianos, as diferenças individuais não se revelaram estatisticamente significantes. Os resultados são comentados em relação aos conhecimentos atuais sobre a patogenia da moléstia de Wilson.



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Departamento de Neuropsiquiatria, Divisão de Neurologia — Faculdade de Medicina, Universidade ãe São Paulo — Caixa Postal 3461 — 01000 São Paulo, SP — Brasil.

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