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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.34 no.4 São Paulo Dec. 1976

http://dx.doi.org/10.1590/S0004-282X1976000400001 

Proteínas totais do liquido cefalorraqueano obtido por punção da cisterna magna: valores normais. Variações ligadas ao sexo

 

Total protein content of normal cisternal cerebrospinal fluid: Variations related to sex

 

 

L. M. Singer VermesI; Rubens Guimarães FerriII; J. AisenIII; J. M. MarletIV

IProf. Assistente do Departamento de Microbiologia e Imunologia do Instituto de Ciências Biomédicas da Univ. de São Paulo
IIProf. Livre-Docente do Departamento de Microbiologia e Imunologia do Instituto de Ciências Biomédicas da Univ. de São Paulo
IIIAssistente da Clínica Neurológica da Faculdade de Medicina da Universidade de São Paulo
IVProf. Livre-Docente do Departamento de Medicina Preventiva da Faculdade de Medicina da Univ. de São Paulo

 

 


RESUMO

Aplicando o método de Lowry, determinamos as proteínas totais do LCR considerado normal de 98 pessoas: 58 do sexo masculino e 40 do feminino. Todas as amostras de LCR foram obtidas por punção da cisterna magna (LCR-SO).
Mediante tratamento estatístico dos valores obtidos, estabelecemos as taxas normais de proteinorraquia cisternal para a população mista: limite superior de 40,36 mg/100 ml, valor médio de 26,78 mg/100 e limite inferior de 13,20 mg/100 ml. Estes valores são superiores àqueles referidos na literatura.
Foi verificado que a proteinorraquia total é, em média, significantemente maior nos indivíduos do sexo masculino, que nos de feminino. Consequentemente estabelecemos em separado os níveis normais de proteínas totais do LCR-SO para pessoas do sexo masculino e feminino.
As taxas médias de proteínas totais do LCR-SO de pessoas do sexo masculino e feminino são de 28,76 e 23,91 mg/100 ml, respectivamente; os limites normais vão de 16,96 a 47,13 mg/100 ml para o sexo masculino e de 14,76 a 42,76 mg/100 ml para o sexo feminino.


SUMMARY

The total protein content of CSF collected from the cisterna magna (cisternal fluid) of 98 patients (58 males and 40 females) with no neurological diseases was determined by the colorimetric method devised by Lowry and co-workers. This method has been previously chosen based mainly on it's sensitivity, accuracy and low fluid consumption. The CSF samples were normal with regard to pressure, color, citology and it's content in glucose, chloride and urea. Complement fixation tests for syphilis and cisticercosis, as well as the globulin tests (Pandy, Nonne — Appelt and Takata-Ara) were negative.
The average value and the normal range of cisternal fluid total protein was calculated for the mixed population (males and females). The mean protein value was 26.78 mg/100 ml, the lower and upper limits were respectively 13.20 and 40.36 mg/100 ml. These data are higher than those stated in some publications, and factors that could interfere in the different results mentioned in the literature are briefly discussed.
Since the statistical analysis of the results showed that the mean total protein concentration in males (28.76 mg/100 ml) was higher than in females (23.91 mg/100 ml), normal limits for each sex were established: 16.96 to 47.13 mg/100 ml for males and 14.76 to 42.76 mg/100 ml for females.


 

 

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