Studies of antithyroid antibodies in Down's syndrome

Schmidt, B. J.; Piva, S.; Schalch, A. L. O.; Ortega, C.; Sousa, M. M.; Torres, D. B.; Krynski, S.

doi:10.1590/S0004-282X1978000400003

Abstracts

The presence of antithyroid antibodies (antithyroglobulin and antimicrosomal) in the serum of patients with Down's syndrome and their respective mothers were studied based on data from the literature, showing a possible correlation between the presence of these antibodies in the serum of mothers and the birth of mongoloid children. Antithyroid antibodies were studied in 40 patients with Down's syndrome, with ages ranging from 5 months to 21 years old, 24 males and 16 females and in the respective mothers whose ages varied from 22 to 66 years. In none of the analyzed sera of the mongoloids as well of their mothers, the authors were able to detect the antithyroid antibodies studied.

Foi estudado no soro de pacientes com síndrome de Down e suas respectivas mães, a presença de anticorpos antitireóide (antitireoglobulina e antimicrossomal), tendo em vista dados de literatura mostrando uma eventual correlação entre a presença destes anticorpos, no soro de mães com filhos, mongolóides. Os anticorpos antitireoideanos foram dosados em 40 pacientes com síndrome de Down, cuja idades variavam 5 meses a 21 anos, sendo 24 masculinos e 16 femininos e, nas respectivas mães, cujas idades variaram de 22 a 66 anos de idade. Em nenhum dos soros analisados, quer dos mongolóides bem como de suas respectivas mães, conseguiu-se detectar os anticorpos antitireoideanos estudados.

Studies of antithyroid antibodies in Down's syndrome

Anticorpos antitireóide na síndrome de Down

B. J. Schmidt^I; S. Piva^II; A. L. O. Schalch^III; C. Ortega^III; M. M. Sousa^III; D. B. Torres^III; S. Krynski^IV

^IProfessor Adjunto e Docente Livre do Departamento de Pediatria da EPM

^IIMédicos. Departamento de Pediatria da EPM

^III Bioquímicos do Centro de Habilitação de São Paulo

^IVDiretor Técnico do Centro de Habilitação de São Paulo

SUMMARY

The presence of antithyroid antibodies (antithyroglobulin and antimicrosomal) in the serum of patients with Down's syndrome and their respective mothers were studied based on data from the literature, showing a possible correlation between the presence of these antibodies in the serum of mothers and the birth of mongoloid children. Antithyroid antibodies were studied in 40 patients with Down's syndrome, with ages ranging from 5 months to 21 years old, 24 males and 16 females and in the respective mothers whose ages varied from 22 to 66 years. In none of the analyzed sera of the mongoloids as well of their mothers, the authors were able to detect the antithyroid antibodies studied.

RESUMO

Foi estudado no soro de pacientes com síndrome de Down e suas respectivas mães, a presença de anticorpos antitireóide (antitireoglobulina e antimicrossomal), tendo em vista dados de literatura mostrando uma eventual correlação entre a presença destes anticorpos, no soro de mães com filhos, mongolóides. Os anticorpos antitireoideanos foram dosados em 40 pacientes com síndrome de Down, cuja idades variavam 5 meses a 21 anos, sendo 24 masculinos e 16 femininos e, nas respectivas mães, cujas idades variaram de 22 a 66 anos de idade. Em nenhum dos soros analisados, quer dos mongolóides bem como de suas respectivas mães, conseguiu-se detectar os anticorpos antitireoideanos estudados.

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Trabalho apresentado na XV Reunião Anual da Sociedade Latino-Americana de Investigação Pediatrics, Cochabamba, Bolivia (5-7 dezembro, 1977), realizado no Centro de Habilitação de São Paulo em colaboração com o Departamento de Pediatria da Escola Paulista de Medicina (EPM), Serviço do Professor A. A. Carvalho.

Departamento de Pediatria - Escola Paulista de Medicina - R. Botucatú 720, 04203 São Paulo, SP - Brasil.

1. AARSKOG, D. - Autoimmune thyroid disease in children with mongolism. Arch. Dis. Childh. 44:454, 1969.
2. BLIZZARD, R. M.; CHANDLER, R. N.; PETIT, M. D. & WEST C. D. - Maternal alloimmunization as a probable cause of athyrotic cretinism. New Engl. J. Med. 263:327, 1960.
3. BURGIO, G. R.; SEVERI, F.; ROSSONI, R. & VACCARO, R. - Mongolism and thyroid autoimmunity. Lancet. 1:166, 1965.
4. BURGIO, G. R.; SEVERI, F.; ROSSONI, R. & VACCARO, R. - Autoantibodies in Down's syndrome. Lancet. 1:497, 1966.
5. DONIACH, D. - Hormonal and genetic aspects of thyroid autoimmunity. In Clinics in Endocrinology and Metabolism - W. J. IRVINE, editor. Volume 4. W. B. Saunders Co., London, 1975, p. 267.
6. FIALKOW, P. J.; HECHT, F.; BRYANT, J. & MOTULSKY, A. G. - Familiar predisposition to chromosomal aberrations. Clin. Res. 13:124, 1965.
7. FIALKOW, P. J.; HECHT, F.; UCHIDA, I. A. & MOTÜLSKY, A. G. - Increased frequency of thyroid autoantibodies in mothers of patients with Down's syndrome. Lancet II:868, 1965.
8. FIALKOW, P. J. - Autoimmunity and chromosomal aberration. Amer. J. Human. Genet. 18:93, 1966.
9. FIALKOW, P. J. - Thyroid antibodies Down's syndrome and maternal age. Nature 214:1253, 1967.
10. FUJITA, K. & YAMADA, N. - Haemagglutination test utilizing the microsomal antigen from thryroid epithelial cells. Clin. Pathol. (Japan) 18:213, 1970.
11. HARRIS, F. & KOUTSOULIERIS, E. - Hypothyroidism due to autoimmune thyroiditis in a young child wilth Dow's syndrome Arch. Dis. Childh. 42:449, 1967.
12. SAXENA, K. M. & PRYLES, C. V. - Thyroid function in mongolism. J. Pediat. 67:363, 1965.
13.SUTHERLAND, J. M.; ESTELBORN, V. M.; BURKET, R. L.; SKILLMAN, T. B., & BENSON, J. T. - Familial non goitrous cretinism apparently due to maternal antithyroid antibody: Report of a family. New Engl. J. Med. 263:336, 1960.

Publication Dates

Publication in this collection
27 Aug 2012
Date of issue
Dec 1978

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[1] 1. AARSKOG, D. - Autoimmune thyroid disease in children with mongolism. Arch. Dis. Childh. 44:454, 1969.

[2] 2. BLIZZARD, R. M.; CHANDLER, R. N.; PETIT, M. D. & WEST C. D. - Maternal alloimmunization as a probable cause of athyrotic cretinism. New Engl. J. Med. 263:327, 1960.

[3] 3. BURGIO, G. R.; SEVERI, F.; ROSSONI, R. & VACCARO, R. - Mongolism and thyroid autoimmunity. Lancet. 1:166, 1965.

[4] 4. BURGIO, G. R.; SEVERI, F.; ROSSONI, R. & VACCARO, R. - Autoantibodies in Down's syndrome. Lancet. 1:497, 1966.

[5] 5. DONIACH, D. - Hormonal and genetic aspects of thyroid autoimmunity. In Clinics in Endocrinology and Metabolism - W. J. IRVINE, editor. Volume 4. W. B. Saunders Co., London, 1975, p. 267.

[6] 6. FIALKOW, P. J.; HECHT, F.; BRYANT, J. & MOTULSKY, A. G. - Familiar predisposition to chromosomal aberrations. Clin. Res. 13:124, 1965.

[7] 7. FIALKOW, P. J.; HECHT, F.; UCHIDA, I. A. & MOTÜLSKY, A. G. - Increased frequency of thyroid autoantibodies in mothers of patients with Down's syndrome. Lancet II:868, 1965.

[8] 8. FIALKOW, P. J. - Autoimmunity and chromosomal aberration. Amer. J. Human. Genet. 18:93, 1966.

[9] 9. FIALKOW, P. J. - Thyroid antibodies Down's syndrome and maternal age. Nature 214:1253, 1967.

[10] 10. FUJITA, K. & YAMADA, N. - Haemagglutination test utilizing the microsomal antigen from thryroid epithelial cells. Clin. Pathol. (Japan) 18:213, 1970.

[11] 11. HARRIS, F. & KOUTSOULIERIS, E. - Hypothyroidism due to autoimmune thyroiditis in a young child wilth Dow's syndrome Arch. Dis. Childh. 42:449, 1967.

[12] 12. SAXENA, K. M. & PRYLES, C. V. - Thyroid function in mongolism. J. Pediat. 67:363, 1965.

[13] 13.SUTHERLAND, J. M.; ESTELBORN, V. M.; BURKET, R. L.; SKILLMAN, T. B., & BENSON, J. T. - Familial non goitrous cretinism apparently due to maternal antithyroid antibody: Report of a family. New Engl. J. Med. 263:336, 1960.