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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.37 no.1 São Paulo Mar. 1979

http://dx.doi.org/10.1590/S0004-282X1979000100006 

Antibioticos profilaticos em neurocirurgia

 

Prophylactic antibiotics in Neurosurgery

 

 

Reynaldo A. BrandtI; Hallin Feres JuniorII

INeuro-cirurgiâo. Serviço de Neuro-cirurgia do Hospital do Servidor Público Estadual (Serviço do Dr. João Teixeira Pinto)
IIRe»idente. Serviço de Neuro-cirurgia do Hospital do Servidor Público Estadual (Serviço do Dr. João Teixeira Pinto)

 

 


RESUMO

O índice de infecções pós-operatórias em pacientes neuro-cirúrgicos que receberam antibióticos profiláticos neste período foi comparado com o de pacientes que não receberam antibióticos. Infecções ocorreram em proporções significativamente maiores nos pacientes que receberam antibióticos, particularmente naqueles com afecções intracranianas graves; estas infecções foram graves e fatais na maioria dos casos. A administração de antibióticos profiláticos nestes pacientes não só foi incapaz de prevenir o aparecimento de infecções pós-operatórias, como aparentemente favoreceu o seu desenvolvimento. Tal se deveu, provavelmente, à destruição do equilíbrio microbiano no organismo, favorecendo o desenvolvimento de germes patogênicos e resistentes aos antibióticos usuais


SUMMARY

The post-operative infection-rate in neurosurgical patients who received prophylactic antibiotics was compared to the infection-rate of patients who received no antibiotics. None of the 73 studied patients had pre-operative infection. Infections occured in 26,4% of the patients in the first group and in none of the second group (p < 0,2); 27,5% of the patients with intracranial lesions and 9% of the patients with spinal lesions in the first group had post-operative infections, and none in the second group (p < 0,05 and 0.05 < p < 0.1). 67% of all the patients had severe neurological lesions; 27% of these had post-operative infections; only 4% of the patients with mild lesions had infections (p < 0.05). Post-operative infections were severe and fatal in most of these cases. Prophylactic broad-spectrum antibiotics were of no value in preventing post-operative infections in these neurosurgical patients and those who received no antibiotics had a significantly lower rate of infections.


 

 

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