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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.37 no.3 São Paulo Sept. 1979 

Potenciales cerebrales ligados a eventos clasification y uso clínico


Cerebral event-related potentials: classification and clinical use



Fernando Lolas

Departamento de Fisiología y Biofísica, Facultad de Medicina Santiago Norte, Chile




Los potenciales ligados a eventos (PLE) constituyen actividad eléctrica cerebral temporalmente asociada a estímulos sensoriales, respuestas motoras y procesos asociativos, registrable mediante promediación por computador. Se presenta una clasificación simplificada de Ias diversas variedades de PLE. Algunos princípios metodológicos son enfatizados en la medida de su relevância clínica en neurologia y psiquiatria. Las principales áreas de aplicación de los PLE son ilustradas mediante datos de la literatura.


Event-related potentials (ERP) constitute an heterogeneous group of brain electrical signals time-locked to sensory stimulation, motor responses, and associative processes, recorded using computer averaging. Several kinds of brain electrical activity are encompassed by the generic term "event related potentials": sensory evoked potentials, time-coherent cerebral events related to motor acta, long-latency potentials associated with psychological variables, slow potential shifts linked to psychological constructs, and "emitted" cerebral events of endogenous origin. Shortcomings of this classification are pointed out and a simpler one is proposed, distinguishing between sensory, motor, and associative time-locked potentials. Their clinical use is illustrated under six major headings: testing of sensory function, localization of lesions, maturation of the central nervous system, genetic markers, evaluation of pharmacologic agents, and indicators of cognitive processes, borne methodological issues relevant to the clinical use of ERP are discussed.



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Departamento de Fiaiologia y Biofísica - Universidad de Chile - Casilla 652k - Santiago 7 - Chile.

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