Aneurismas experimentais: proposição de nova tecnica

Siqueira, Mario G.; Rojas, Raul A. Galeno; Sturion, Domingos J.

doi:10.1590/S0004-282X1980000100003

Resumos

Com a finalidade de avaliar a eficácia de um procedimento terapêutico, os autores realizaram uma análise crítica dos vários métodos para produção experimental de aneurismas e elaboraram um método próprio, baseado em uma técnica pré-existente, no qual aneurismas saculares foram produzidos na bifurcação da artéria carótida comum de cães, com enxertos de fragmentos de veias. Os aneurismas assim produzidos apresentaram uma baixa incidência de trombose e uma tendência em aumentar de tamanho e em tornarem-se esféricos. As características desses aneurismas em muito se assemelham àquelas dos aneurismas de ocorrência natural nas artérias cerebrais do homem, o que os tornam modelos úteis para fins experimentais.

The authors present a critical analysis of the various methods of experimental production of aneurysms and report their own method in which saccular aneurysms were produced at the bifurcation of the common carotid artery in dogs with vein patch grafts. The objective point of this study was the creation of an experimental model to evaluate the efficacy of a therapeutic procedure. These aneurysms have a low incidence of thrombosis and a tendency to enlarge and to become spherical. They closely simulate the saccular aneurysms developing spontaneously in the cerebral arteries of man, and as such are useful models for experimental purposes.

Aneurismas experimentais: proposição de nova tecnica

Experimental aneurysms: proposal of a new technic

Mario G. Siqueira^I; Raul A. Galeno Rojas^II; Domingos J. Sturion^III

^IChefe do Serviço de Neurocirurgia do Hospital Evangélico de Londrina

^IIAuxiliar de Ensino de Clínica Cirúrgica da Escola de Medicina Veterinária da Fundação Universitária Estadual de Londrina

^IIIAuxiliar de Ensino de Radiologia da Escola de Medicina Veterinária da Fundação Universidade Estadual de Londrina

RESUMO

Com a finalidade de avaliar a eficácia de um procedimento terapêutico, os autores realizaram uma análise crítica dos vários métodos para produção experimental de aneurismas e elaboraram um método próprio, baseado em uma técnica pré-existente, no qual aneurismas saculares foram produzidos na bifurcação da artéria carótida comum de cães, com enxertos de fragmentos de veias. Os aneurismas assim produzidos apresentaram uma baixa incidência de trombose e uma tendência em aumentar de tamanho e em tornarem-se esféricos.

As características desses aneurismas em muito se assemelham àquelas dos aneurismas de ocorrência natural nas artérias cerebrais do homem, o que os tornam modelos úteis para fins experimentais.

SUMMARY

The authors present a critical analysis of the various methods of experimental production of aneurysms and report their own method in which saccular aneurysms were produced at the bifurcation of the common carotid artery in dogs with vein patch grafts. The objective point of this study was the creation of an experimental model to evaluate the efficacy of a therapeutic procedure. These aneurysms have a low incidence of thrombosis and a tendency to enlarge and to become spherical. They closely simulate the saccular aneurysms developing spontaneously in the cerebral arteries of man, and as such are useful models for experimental purposes.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Nota dos autores - Nossos agradecimentos aos Labortórios Ayerst Ltda. pela colaboração prestada.

Rua Cambará 562 - 86100 Londrina, PR - Brasil.

1. BLACK, S. P. W. - Experimental saccular aneurysm by an arterio-venous fistula method. Missouri Med. (Fulton) 60:340, 1963.
2. BLACK, S. P. W. & GERMAN, W. J. - Observations on the relationship between the volume and the size of the orifice of experimental aneurysms. J. Neurosurg. 17:984, 1960.
3. DAVIS, D. O. & RUMBAUGH, C. L. - Cerebral angiography in the dog: method for consistent results. Invest. Radiol. 2:323, 1967.
4. De La TORRE, E.; NETSKY, M. G. & MESCHAN, I. - Intracranial and extracranial circulation in the dog: anatomic and angiography studies. Am. J. Anat. 106:343, 1959.
5. DERUTY, R.; BRET, Ph.; DECHAUME, J. P.; LAPRAS; C. L.; LECTURE, J. & HOPP, N. - Anevrysmes experimentaux chez le rat: problemes techniques et aspects histologiques Revue Oto-Neuro-Ophtal. (Paris) 47:43, 1975.
6. FERGUSON, G. G. - Turbulence in human intracranial saccular aneurysms. J. Neurosurg. 33:485, 1970.
7. FERGUSON, G. G. - Physical factors in the initiation, growth, and rupture of human intracranial saccular aneurysms. J. Neurosurg. 37:666, 1972.
8. GERMAN, W. J. & BLACK, S. P. W. - Experimental production of carotid aneurysms. New Engl. J. Med. 250:104, 1954.
9. GERMAN, W. J. & BLACK, S. P. W. - Intra-aneurysmal hemodynamics: jet action. Circulat. Res. (New York) 3:463, 1955.
10. GUERRISI, R. & YASARGIL, M. G. - Studio sperimentale su anevrismi artificialmente creati con l'ausilio del microscopio in ratti e conigli. Min. Neurochirurg. 14:140, 1970.
11. HASHIMOTO, N.; HANDA, H. & HAZAMA; F. - Experimentally induced cerebral aneurysms in rats. Surg. Neurol. 10:3, 1978.
12. HASHIMOTO, N.; HANDA, H. & HAZAMA, F. - Experimentally induced cerebral aneurysms in rats: part II. Surg. Neurol. 11:243, 1979.
13. HASHIMOTO, N.; HANDA, H. & HAZAMA, F. - Experimentally induced cerebral aneurysms in rats: part III, pathology. Surg. Neurol. 11:299, 1979.
14. McCUNE, W. S.; SAMADI, A. & BLADES, B. - Experimental aneurysms. Ann. Surg. 138:216, 1953.
15. MORITAKI, K.; HANDA, H.; HAYASHI; K. & SATO, M. - Experimental studies of intracranial aneurysms: some biomechanical considerations on the &all structures of intracranial aneurysms and experimentally produced aneurysms. Neurol. Surg. (Tokio) 1:115, 1973.
16. NISHIKAWA, M.; SMITH, R. D. & YONEKAWA, Y. - Experimental intracranial aneurysms. Surg. Neurol. 7:241, 1977.
17. NISHIKAWA, M.; YONEKAWA, Y. & MATSUDA, I. - Experimental aneurysms. Surg. Neurol. 5:15, 1976.
18. SHUMACKER Jr., H. B. & LOWENBERG, R. I. - Experimental studies in vascular repair: 1 - comparison of reliability of various methods of end-to-end arterial sutures. Surgery 24:79, 1948.
19. STEHBENS, W. E. - Experimental production of aneurysms by microvascular surgery in rabbits. Vascul. Surg. 7:165, 1973.
20. WHITE, J. C.; SAYRE, G. P. & WHISNANT, J. P. - Experimental destruction of the media for the production of intracranial arterial aneurysms. J. Neurosurg. 18:741, 1961.

Datas de Publicação

Publicação nesta coleção
22 Ago 2012
Data do Fascículo
Mar 1980

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. BLACK, S. P. W. - Experimental saccular aneurysm by an arterio-venous fistula method. Missouri Med. (Fulton) 60:340, 1963.

[2] 2. BLACK, S. P. W. & GERMAN, W. J. - Observations on the relationship between the volume and the size of the orifice of experimental aneurysms. J. Neurosurg. 17:984, 1960.

[3] 3. DAVIS, D. O. & RUMBAUGH, C. L. - Cerebral angiography in the dog: method for consistent results. Invest. Radiol. 2:323, 1967.

[4] 4. De La TORRE, E.; NETSKY, M. G. & MESCHAN, I. - Intracranial and extracranial circulation in the dog: anatomic and angiography studies. Am. J. Anat. 106:343, 1959.

[5] 5. DERUTY, R.; BRET, Ph.; DECHAUME, J. P.; LAPRAS; C. L.; LECTURE, J. & HOPP, N. - Anevrysmes experimentaux chez le rat: problemes techniques et aspects histologiques Revue Oto-Neuro-Ophtal. (Paris) 47:43, 1975.

[6] 6. FERGUSON, G. G. - Turbulence in human intracranial saccular aneurysms. J. Neurosurg. 33:485, 1970.

[7] 7. FERGUSON, G. G. - Physical factors in the initiation, growth, and rupture of human intracranial saccular aneurysms. J. Neurosurg. 37:666, 1972.

[8] 8. GERMAN, W. J. & BLACK, S. P. W. - Experimental production of carotid aneurysms. New Engl. J. Med. 250:104, 1954.

[9] 9. GERMAN, W. J. & BLACK, S. P. W. - Intra-aneurysmal hemodynamics: jet action. Circulat. Res. (New York) 3:463, 1955.

[10] 10. GUERRISI, R. & YASARGIL, M. G. - Studio sperimentale su anevrismi artificialmente creati con l'ausilio del microscopio in ratti e conigli. Min. Neurochirurg. 14:140, 1970.

[11] 11. HASHIMOTO, N.; HANDA, H. & HAZAMA; F. - Experimentally induced cerebral aneurysms in rats. Surg. Neurol. 10:3, 1978.

[12] 12. HASHIMOTO, N.; HANDA, H. & HAZAMA, F. - Experimentally induced cerebral aneurysms in rats: part II. Surg. Neurol. 11:243, 1979.

[13] 13. HASHIMOTO, N.; HANDA, H. & HAZAMA, F. - Experimentally induced cerebral aneurysms in rats: part III, pathology. Surg. Neurol. 11:299, 1979.

[14] 14. McCUNE, W. S.; SAMADI, A. & BLADES, B. - Experimental aneurysms. Ann. Surg. 138:216, 1953.

[15] 15. MORITAKI, K.; HANDA, H.; HAYASHI; K. & SATO, M. - Experimental studies of intracranial aneurysms: some biomechanical considerations on the &all structures of intracranial aneurysms and experimentally produced aneurysms. Neurol. Surg. (Tokio) 1:115, 1973.

[16] 16. NISHIKAWA, M.; SMITH, R. D. & YONEKAWA, Y. - Experimental intracranial aneurysms. Surg. Neurol. 7:241, 1977.

[17] 17. NISHIKAWA, M.; YONEKAWA, Y. & MATSUDA, I. - Experimental aneurysms. Surg. Neurol. 5:15, 1976.

[18] 18. SHUMACKER Jr., H. B. & LOWENBERG, R. I. - Experimental studies in vascular repair: 1 - comparison of reliability of various methods of end-to-end arterial sutures. Surgery 24:79, 1948.

[19] 19. STEHBENS, W. E. - Experimental production of aneurysms by microvascular surgery in rabbits. Vascul. Surg. 7:165, 1973.

[20] 20. WHITE, J. C.; SAYRE, G. P. & WHISNANT, J. P. - Experimental destruction of the media for the production of intracranial arterial aneurysms. J. Neurosurg. 18:741, 1961.