Uso de um inibidor prostaglandinico nas crises de enxaqueca: estudo de 40 casos

Werneck Neto, Antonio Luiz dos Santos; Mariotto, Gilnise do Socorro Sales; Xavier, Antonieta Campos

doi:10.1590/S0004-282X1980000200003

Resumos

Um anti-inflamatório não esteróide (indometacina) foi utilizado em um grupo de 40 pacientes com enxaqueca. O medicamento foi utilizado apenas durante as crises, sendo obtidos resultados positivos em 72% dos casos. Esta é a primeira vez que se realiza um trabalho estatístico com esta substância nas crises de enxaqueca. Vinte e seis pacientes já haviam utilizado a ergotamina em larga escala sem apresentar melhoras.

An anti-inflamatory nonsteroidal drug (indomathacin) was employed in a group of 40 migrainous patients. The drug was utilized just during the attacks. Positive results were obtained in 72% of the cases. Twenty-six patients had already utilized the ergotamine tartrate on a large scale without improvement.

Uso de um inibidor prostaglandinico nas crises de enxaqueca: estudo de 40 casos

Use of a prostanglandin inhibitor in migraine attacks

Antonio Luiz dos Santos Werneck Neto^I; Gilnise do Socorro Sales Mariotto^II; Antonieta Campos Xavier^II

^INeurologista. Serviço de Neurologia do Hospital Central do Instituto de Assistência aos Servidores do Estado do Rio de Janeiro

^IIMédicas residentes. Serviço de Neurologia do Hospital Central do Instituto de Assistência aos Servidores do Estado do Rio de Janeiro

RESUMO

Um anti-inflamatório não esteróide (indometacina) foi utilizado em um grupo de 40 pacientes com enxaqueca. O medicamento foi utilizado apenas durante as crises, sendo obtidos resultados positivos em 72% dos casos. Esta é a primeira vez que se realiza um trabalho estatístico com esta substância nas crises de enxaqueca. Vinte e seis pacientes já haviam utilizado a ergotamina em larga escala sem apresentar melhoras.

SUMMARY

An anti-inflamatory nonsteroidal drug (indomathacin) was employed in a group of 40 migrainous patients. The drug was utilized just during the attacks. Positive results were obtained in 72% of the cases. Twenty-six patients had already utilized the ergotamine tartrate on a large scale without improvement.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Trabalho realizado no Serviço de Neurologia do Hospital Central do Instituto de Assistência aos Servidores do Estado do Rio de Janeiro, apresentado no VIII Congresso Brasileiro de Neurologia (Brasilia, D. F.) em Setembro - 1978.

Serviço de Neurologia, Hospital Central do Instituto de Assistência dos Servidores do Estado do Rio de Janeiro, Brasil.

1. CARLSON, L. A.; EKELUND, L. G. & ORO, L. - Clinical and metabolic effects of different dosea of prostaglandin El in man. Acta med. Scand. 183:423, 1968.
2. CLARK, D.; HOUGH, H. B. & WOLFF, H. G. - Experimental studies on headache: observations on headache produced by histamine. Arch. Neurol. Psychiat. (Chicago) 35:1054, 1936.
3. COLLIER, H. O. J. & SWEATMAN, W. J. F. - Antagonism by fenamates of prostaglandin F2 alfa and slow reacting substance on human bronchial muscle. Nature 219:865, 1968.
4. DENTON, I. C. JR; WHITE, K. P. & ROBERTSON, J. T. - The effects of prosftaglandins El, Al and F2 alfa on the cerebral circulation of dogs and monkeys. J. Neurosurg. 36:34, 1972.
5. GOODELL, H.; LEWONTIN, R. & WOLFF, H. G. - Familial occurence of migraine headache. A study of heredity. Arch. Neurol. Psychiat. (Chicago) 72:325, 1954.
6. GRAHAM, J. R. & WOLFF, H. G. - Mechanism of migraine headache and action of ergotamine tartrate. Proc. Ass. Res. Nerv. Ment. Dis. 18:638, 1937.
7. HOLMES, S. W. & HORTON, E. W. - The identification of four prostaglandins in the dog brain and their regional distribution in the central nervous system. J. Physiol. (London) 195:731, 1968.
8. KUNXLE, E. C; LUND, D. W. & MAHER, P. J. - Analysis of vascular mechanisms in headache by use of the human centrifuge, with observations upon pain perception under increased positive G. Arch. Neurol. Psychiat. (Chicago) 60:253, 1948.
9. NAKANO, J.; CHANG, A. C. K. & FISCHER, R. G. - Effects of prostaglandins El, E2, Al, A2 and alfa on canine carotid arterial blood flow, cerebrospinal fluid pressure and intraocular pressure. J. Neurosurg. 38:32. 1973.
10. OSTFELD, A. M.; CHAPMAN, L. F.: GOODELL, H. & WOLFF, H. G. - Studies in headache: summary of evidence concerning anoxious agent active locally during migraine headache. Psychosom. Med. 19:199. 1957.
11. PELOFSKYS, E.; JACOBSON, E. D. & FISHER, R. G. - Effects of prostaglandin El on experimental cerebral vasopasm. J. Neurosurg. 36:634, 1972.
12. PENNINK, M.; WHITE, R. P. & CROCKARELL, J. T. - Role of prostaglandin F2 alfa in the genesis- of experimental vasopasm. J. Neurosurg. 37:398, 1972.
13. SKINHOJ, E. & PAULSON, O. B. - Regional blood flow in internal carotid distribution during migraine attack. British Med. J. 3:569, 1969.
14. VARDI, Y.; RABEY, I. M.; STREIFLER, M.; SCHWARTZ, A.; LINDNER, H. R. .& ZOR, U. - Migraine attacks alleviations by and inhibitor of prostaglandin synthesis and action. Neurology (Minneapolis) 26:447, 1976.
15. WELCH, K. M. A.; SPIRA, P. J.; KNOWLES, L. & LANCE, J. W. - Effects of prostaglandins on the internal and external carotid blood flow in the monkey. Neurology (Minnneapolis) 24:705, 1974.

Datas de Publicação

Publicação nesta coleção
23 Ago 2012
Data do Fascículo
Jun 1980

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. CARLSON, L. A.; EKELUND, L. G. & ORO, L. - Clinical and metabolic effects of different dosea of prostaglandin El in man. Acta med. Scand. 183:423, 1968.

[2] 2. CLARK, D.; HOUGH, H. B. & WOLFF, H. G. - Experimental studies on headache: observations on headache produced by histamine. Arch. Neurol. Psychiat. (Chicago) 35:1054, 1936.

[3] 3. COLLIER, H. O. J. & SWEATMAN, W. J. F. - Antagonism by fenamates of prostaglandin F2 alfa and slow reacting substance on human bronchial muscle. Nature 219:865, 1968.

[4] 4. DENTON, I. C. JR; WHITE, K. P. & ROBERTSON, J. T. - The effects of prosftaglandins El, Al and F2 alfa on the cerebral circulation of dogs and monkeys. J. Neurosurg. 36:34, 1972.

[5] 5. GOODELL, H.; LEWONTIN, R. & WOLFF, H. G. - Familial occurence of migraine headache. A study of heredity. Arch. Neurol. Psychiat. (Chicago) 72:325, 1954.

[6] 6. GRAHAM, J. R. & WOLFF, H. G. - Mechanism of migraine headache and action of ergotamine tartrate. Proc. Ass. Res. Nerv. Ment. Dis. 18:638, 1937.

[7] 7. HOLMES, S. W. & HORTON, E. W. - The identification of four prostaglandins in the dog brain and their regional distribution in the central nervous system. J. Physiol. (London) 195:731, 1968.

[8] 8. KUNXLE, E. C; LUND, D. W. & MAHER, P. J. - Analysis of vascular mechanisms in headache by use of the human centrifuge, with observations upon pain perception under increased positive G. Arch. Neurol. Psychiat. (Chicago) 60:253, 1948.

[9] 9. NAKANO, J.; CHANG, A. C. K. & FISCHER, R. G. - Effects of prostaglandins El, E2, Al, A2 and alfa on canine carotid arterial blood flow, cerebrospinal fluid pressure and intraocular pressure. J. Neurosurg. 38:32. 1973.

[10] 10. OSTFELD, A. M.; CHAPMAN, L. F.: GOODELL, H. & WOLFF, H. G. - Studies in headache: summary of evidence concerning anoxious agent active locally during migraine headache. Psychosom. Med. 19:199. 1957.

[11] 11. PELOFSKYS, E.; JACOBSON, E. D. & FISHER, R. G. - Effects of prostaglandin El on experimental cerebral vasopasm. J. Neurosurg. 36:634, 1972.

[12] 12. PENNINK, M.; WHITE, R. P. & CROCKARELL, J. T. - Role of prostaglandin F2 alfa in the genesis- of experimental vasopasm. J. Neurosurg. 37:398, 1972.

[13] 13. SKINHOJ, E. & PAULSON, O. B. - Regional blood flow in internal carotid distribution during migraine attack. British Med. J. 3:569, 1969.

[14] 14. VARDI, Y.; RABEY, I. M.; STREIFLER, M.; SCHWARTZ, A.; LINDNER, H. R. .& ZOR, U. - Migraine attacks alleviations by and inhibitor of prostaglandin synthesis and action. Neurology (Minneapolis) 26:447, 1976.

[15] 15. WELCH, K. M. A.; SPIRA, P. J.; KNOWLES, L. & LANCE, J. W. - Effects of prostaglandins on the internal and external carotid blood flow in the monkey. Neurology (Minnneapolis) 24:705, 1974.