Tumores primarios intracranianos: analise de uma serie de autopsias e biopsias consecutivas

Lana-Peixoto, Marco Aurelio; Pittella, Jose Eymard Homem; Arouca, Eustaquio Martins Gomes

doi:10.1590/S0004-282X1981000100002

Resumos

Entre 19.760 autópsias e 72.972 biópsias consecutivas, num período de 41 anos e 4 meses, foram encontrados 294 tumores intracranianos primários representando 74,8% das lesões expansivas intracranianas. Cerca de dois terços destes tumores se localizavam no compartimento supratentorial. Os gliomas foram os tumores mais freqüentemente observados, seguidos pelos meningiomas, adenomas hipofisários, tumores de origem embrionária e tumores vasculares. Na região selar foram diagnosticados 39 tumores, incluindo os tumores intra-selares, supraselares e paraselares. A maior parte destes tumores foi constituída pelos adenomas hipofisários, seguidos pelos craniofaringiomas, meningiomas, cistos epidermóides e teratomas. Setenta e cinco tumores foram verificados em pacientes com idade inferior a 15 anos, sendo a maioria deles na fossa posterior, principalmente no cerebelo. Estes tumores foram representados pelos astrocitomas do cerebelo e tronco encefálico, meduloblastomas e ependimomas do quarto ventrículo. Os dados obtidos foram comparados com as várias séries encontradas na literatura.

A retrospective study of primary intracranial tumors found in 19.760 consecutive autopsies and 72.972 consecutive biopsies during a period of over 41 years was carried out. Two hundred and five neoplasms comprising 69,7% of the primary intracranial tumors were located in the supratentorial compartment whereas 84 tumors (28,6%) were infratentorial in site. Gliomas constituted the largest group of primary tumors comprising 60,9% of the intracranial primary neoplasms. Most of gliomas were found in the cerebral hemispheres, particularly in the frontal lobes. Of the total number of gliomas 40,2% were astrocytomas, 29,6% glioblastomas, 10,6% ependymomas, 10,1% medulloblasto-mas, 5% oligodendrogliomas and 2,2% choroid plexus papillomas. Meningiomas constituted the second most common primary intracranial tumors being found in 56 cases (19%), most of them in parasagittal region, sphenoid ridge and anterior fossa. In the sella region there were 39 neoplasms including 21 pituitary adenomas, seven meningiomas, five craniopharyngiomas, four epidermoid cysts and two teratomas. Six capillary hemangioblastomas of the cerebellum and two chordomas of the clivus were also found. Sixty-five tumors occurred in patients under 15 years of age, 53,3% of them infratentorial in location - 36% in the cerebellum, 9,3% in the brainstem and 8% in the fourth ventricle. The majority of these tumors were astrocytomas, medulloblastomas and ependymomas. The present data are discussed in relation to other pathological series found in the literature.

Tumores primarios intracranianos: analise de uma serie de autopsias e biopsias consecutivas

Primary intracranial tumors: analysis of a series of consecutive autopsies and biopsies

Marco Aurelio Lana-Peixoto^I; Jose Eymard Homem Pittella^I; Eustaquio Martins Gomes Arouca^II

^IProfessor Assistente. Departamentos de Neurologia e Anatomia Patológica da Faculdade de Medicina da UFMG, Belo Horizonte (MG)

^IIAcadêmico. Departamentos de Neurologia e Anatomia Patológica da Faculdade de Medicina da UFMG, Belo Horizonte (MG)

RESUMO

Entre 19.760 autópsias e 72.972 biópsias consecutivas, num período de 41 anos e 4 meses, foram encontrados 294 tumores intracranianos primários representando 74,8% das lesões expansivas intracranianas. Cerca de dois terços destes tumores se localizavam no compartimento supratentorial. Os gliomas foram os tumores mais freqüentemente observados, seguidos pelos meningiomas, adenomas hipofisários, tumores de origem embrionária e tumores vasculares. Na região selar foram diagnosticados 39 tumores, incluindo os tumores intra-selares, supraselares e paraselares. A maior parte destes tumores foi constituída pelos adenomas hipofisários, seguidos pelos craniofaringiomas, meningiomas, cistos epidermóides e teratomas. Setenta e cinco tumores foram verificados em pacientes com idade inferior a 15 anos, sendo a maioria deles na fossa posterior, principalmente no cerebelo. Estes tumores foram representados pelos astrocitomas do cerebelo e tronco encefálico, meduloblastomas e ependimomas do quarto ventrículo. Os dados obtidos foram comparados com as várias séries encontradas na literatura.

SUMMARY

A retrospective study of primary intracranial tumors found in 19.760 consecutive autopsies and 72.972 consecutive biopsies during a period of over 41 years was carried out. Two hundred and five neoplasms comprising 69,7% of the primary intracranial tumors were located in the supratentorial compartment whereas 84 tumors (28,6%) were infratentorial in site. Gliomas constituted the largest group of primary tumors comprising 60,9% of the intracranial primary neoplasms. Most of gliomas were found in the cerebral hemispheres, particularly in the frontal lobes. Of the total number of gliomas 40,2% were astrocytomas, 29,6% glioblastomas, 10,6% ependymomas, 10,1% medulloblasto-mas, 5% oligodendrogliomas and 2,2% choroid plexus papillomas. Meningiomas constituted the second most common primary intracranial tumors being found in 56 cases (19%), most of them in parasagittal region, sphenoid ridge and anterior fossa. In the sella region there were 39 neoplasms including 21 pituitary adenomas, seven meningiomas, five craniopharyngiomas, four epidermoid cysts and two teratomas. Six capillary hemangioblastomas of the cerebellum and two chordomas of the clivus were also found. Sixty-five tumors occurred in patients under 15 years of age, 53,3% of them infratentorial in location - 36% in the cerebellum, 9,3% in the brainstem and 8% in the fourth ventricle. The majority of these tumors were astrocytomas, medulloblastomas and ependymomas. The present data are discussed in relation to other pathological series found in the literature.

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Departamento de Neurologia - Faculdade de Medicina da UFMO - Avenida Alfredo Balena 190 - 30000 Belo Borizzonte, MG - Brasil.

1. BANERJEE, A. K.; SAMANTA, H. K. & AIKAT, B. K. - Intracranial spaceoccupying lesions: an analysis of 200 cases. Indian J. Pathol. Bacteriol. 15:83, 1972.
2. COURVILLE, B. C. - Pathology of the Central Nervous System. Pacific Press, California, 1941.
3. CUNEO, M. H. & RAND. C. W. - Brain Tumors of Chilhood. Charles C. Thomas. Springfield (Illinois), 1952.
4. CUSHING, H. W. - The intracranial trmors of prea-olescence. Amer. J. Dis. Child. 33:551, 1927.
5. CUSHING, H. W. - Intracranial Tumours. Charles C. Thomas, Springfield (Illinois). 1932.
6. DASTUR, D. K.; LALITHA, V. S. & PRABHAKAR. V. - Pathological analysis of intracranial space-occupying lesions in 1000 cases, including children: age. sex and pattern and the the tuberculomas. J. Neurol. Sci. 6:575, 1968.
7. DASTUR, D. K. & LALITHA, V. S. - Pathological analysis of intracranial spaceoccupying lesions in 1030 cases, including children: incidence, types and unusual cases of glioma. J. Neurol. Sci. 8:143, 1969.
8. GRANT, F. C. - A study of the results of surgical treatment in 2326 consecutive patients with brain tumors. J. Neurosurg. 13:476, 1955.
9. HOOPER, R. - Intracranial tumors in chilhood. Med. J. Aust. 1:624. 1976.
10. INGRAHAM, F. D. & MATSON, D. D. - Neurosurgery of Infancy and Childhood. Charles C. Thomas, Springfield (Illinois), 1961.
11. KATSURA, S.: SUZUKI, J. & WADA, T. - A statistical study of brain tumors in the neurosurgical clinics in Japan. J. Neurosurg. 16:570, 1959.
12. OLIVECRONA, H. - Citado por KATSURA. S. e col.. 1959.
13. RAMAMURTHI, B. - Citado por DASTUR, D.K. e col., 1968.
14. RUBINSTEIN, L. J. - Tumors of the Central Nervous System. Armed Forces Institute of Pathology, Washington D.C., 1972.
15. RUSSEL, D. S. & RUBINSTEIN, L. J. - Pathology of Tumors of the Nervous System. Williams and Wilkins Co. Baltimore, 1971.
16. SALLUM, J. - Tumores intracranianos, intraraquidianos e dos nervos periféricos In Bogliolo, L. - Patologia. Guanabara-Koogan, Rio de Janeiro. 1976.
17. WILLIS. R. A. - The Pathology of the Tumours of Children. Oliver and Boyd, London-Edinburgh, 1962.
18. ZÜLCH, K. J. - Brain Tumours, their Biology and Pathology. Springer Verlag. New York. 1957.

Datas de Publicação

Publicação nesta coleção
20 Ago 2012
Data do Fascículo
Mar 1981

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. BANERJEE, A. K.; SAMANTA, H. K. & AIKAT, B. K. - Intracranial spaceoccupying lesions: an analysis of 200 cases. Indian J. Pathol. Bacteriol. 15:83, 1972.

[2] 2. COURVILLE, B. C. - Pathology of the Central Nervous System. Pacific Press, California, 1941.

[3] 3. CUNEO, M. H. & RAND. C. W. - Brain Tumors of Chilhood. Charles C. Thomas. Springfield (Illinois), 1952.

[4] 4. CUSHING, H. W. - The intracranial trmors of prea-olescence. Amer. J. Dis. Child. 33:551, 1927.

[5] 5. CUSHING, H. W. - Intracranial Tumours. Charles C. Thomas, Springfield (Illinois). 1932.

[6] 6. DASTUR, D. K.; LALITHA, V. S. & PRABHAKAR. V. - Pathological analysis of intracranial space-occupying lesions in 1000 cases, including children: age. sex and pattern and the the tuberculomas. J. Neurol. Sci. 6:575, 1968.

[7] 7. DASTUR, D. K. & LALITHA, V. S. - Pathological analysis of intracranial spaceoccupying lesions in 1030 cases, including children: incidence, types and unusual cases of glioma. J. Neurol. Sci. 8:143, 1969.

[8] 8. GRANT, F. C. - A study of the results of surgical treatment in 2326 consecutive patients with brain tumors. J. Neurosurg. 13:476, 1955.

[9] 9. HOOPER, R. - Intracranial tumors in chilhood. Med. J. Aust. 1:624. 1976.

[10] 10. INGRAHAM, F. D. & MATSON, D. D. - Neurosurgery of Infancy and Childhood. Charles C. Thomas, Springfield (Illinois), 1961.

[11] 11. KATSURA, S.: SUZUKI, J. & WADA, T. - A statistical study of brain tumors in the neurosurgical clinics in Japan. J. Neurosurg. 16:570, 1959.

[12] 12. OLIVECRONA, H. - Citado por KATSURA. S. e col.. 1959.

[13] 13. RAMAMURTHI, B. - Citado por DASTUR, D.K. e col., 1968.

[14] 14. RUBINSTEIN, L. J. - Tumors of the Central Nervous System. Armed Forces Institute of Pathology, Washington D.C., 1972.

[15] 15. RUSSEL, D. S. & RUBINSTEIN, L. J. - Pathology of Tumors of the Nervous System. Williams and Wilkins Co. Baltimore, 1971.

[16] 16. SALLUM, J. - Tumores intracranianos, intraraquidianos e dos nervos periféricos In Bogliolo, L. - Patologia. Guanabara-Koogan, Rio de Janeiro. 1976.

[17] 17. WILLIS. R. A. - The Pathology of the Tumours of Children. Oliver and Boyd, London-Edinburgh, 1962.

[18] 18. ZÜLCH, K. J. - Brain Tumours, their Biology and Pathology. Springer Verlag. New York. 1957.