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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.40 no.1 São Paulo Mar. 1982

http://dx.doi.org/10.1590/S0004-282X1982000100001 

Evaluation of flurazepam and placebo on sleep disorders in childhood

 

Avaliação de flurazepam e placebo nos distúrbios do sono na infância

 

 

Rubens ReimãoI; Antonio B. LefévreII

IAssociate Physician of Child Neurology. Department of Neuropsychiatry - "Hospital das Clínicas" - University of Sao Paulo School of Medicine
IIHead of the Department of Child Neurology. Department of Neuropsychiatry - "Hospital das Clínicas" - University of Sao Paulo School of Medicine

 

 


SUMMARY

The clinically observed results in 40 patients, from 1 to 15 years old, presenting sleep disturbances, in a comparative and statistically approached study of flurazepam 15mg daily against placebo, are reported. Placebo was administered, followed by the drug, during 14 days each. The chief complaints were sleepwalking, sleep-talking, sleep terror, sleep-related bruxism, sleep-related headbanging, insomnia and excessive movements during sleep. A significant effect of flurazepam on sleepwalking, sleep-talking, bruxism, sleep terror and excessive movement during sleep, was observed. The insomniac and headbanging patients were not enough for statistical analysis. Flurazepam side effects were excessive drowsiness during daytime in 3 cases; irritability, 3 cases; nausea and vomiting, 2 cases, and were not correlated with age. Placebo side effects were similar, except for nausea and vomiting which were not observed. It was necessary to discontinue flurazepam in 2 cases, because of excessive drowsiness during daytime, which did not improve when reducing the dose.


RESUMO

Os autores relatam os efeitos de flurazepam e placebo em estudo comparativo, em 40 crianças com distúrbios do sono. As alterações observadas são: sonambulismo, terror noturno, sonilóquio, bruxismo durante o sono, jactatio capitis nocturnus, insonia e movimentação excessiva durante o sono. São analisadas a ação da droga assim como a ocorrência de efeitos colaterais.


 

 

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Study performed by the Department of Neuropsychiatry - "Hospital das Clínicas" - University of Sao Paulo School of Medicine.
Acknowledgement: We thank Mrs. Jadwiga Myelinska for the statistical analysis.
Address reprints request to: Dr. Rubens Reimão - Clínica Neurológica, Departamento de Neuropsiquiatria - Faculdade de Medicina da Universidade de São Paulo - Caixa Postal 8461 - 01000 São Paulo, SP - Brasil.

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