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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.40 no.3 São Paulo Sept. 1982

http://dx.doi.org/10.1590/S0004-282X1982000300012 

Aspectos neuroquimicos do parkinsonismo: revisão da literatura

 

Neurochemistry aspects of parkinsonism: a review of literature

 

 

James Pitagoras de MattosI; Claudio CechelaII; Jonatas Galvarros AdamsIII; José Mauro Braz de LimaI

IProfessor Assistente. Instituto de Neurologia Deolindo Couto da UFRJ (Serviço do Prof. Bernardo Couto)
IIMestre em Neurologia. Instituto de Neurologia Deolindo Couto da UFRJ (Serviço do Prof. Bernardo Couto)
IIIResidente. Instituto de Neurologia Deolindo Couto da UFRJ (Serviço do Prof. Bernardo Couto)

 

 


RESUMO

Os autores fazem revisão da literatura sobre os dados neuroquímicos até agora encontrados na síndrome parkinsoniana. Analisam as alterações das concentrações da dopamina, da acetilcolina, da serotonina, da noradrenalina, de enzimas, do ácido neuroamínico e de alguns metais e amino-ácidos, concluindo pela provável existência de defeito neuroquimico mais generalizado na condição em apreço.


SUMMARY

The authors make a revision of literature on neurochemistry data, up to now found Parkinson's. They study the concentrations alteration of dopamine, acetylcholine, serotonin, noradrenalin, enzymes, neutroaminic acid, metals and amynoacids, concluding on the possible existence of a neurochemistry defect more generalized in the forementioned condition.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

REFERENCIAS

1. BARBEAU, A.; MURPHY, G. F. & SOURKES, T. L. - Excretion of dopamine in diseases of basal ganglia. Science 133:1706, 1961.         [ Links ]

2. BARBEAU, A. & JASMIN, G. - Dosage de l'acide 5-hydroxy-indolacetique urinaire dans la maladie de Parkinson. Rev. Canad. Biol, 20:837, 1961.         [ Links ]

3. BARBEAU, A. - Parkinson's disease as a systemic disorder. In GILLINGHAN, F. J. & DONALDSON, I M. L. eds. - Symposium on Parkinson's Disease. 3rs, Royal College of Surgeons of Edinburg. May 1968, Livingstone, 1969, págs. 66/73.         [ Links ]

4. BAROLIN, G. S.; BERHEIMER, H. & HORNYKIEWICZ, O. - Seitenverschiedenes Verhalten des Dopamine (3-Hydroxytyramin) im Gehirn eines Falles von Hemiparkinsonismus. Schweiz. Arch. Neurol. Psychiat., 94:241, 1964.         [ Links ]

5. BERNHEIMER, H.; BIRKMAYER, W. & HORNYKIEWICZ, O. - Verteilung des 5-Hydroxytryptamins (Serotonin) im Gehirn des Menschen und sein Verhalten bei Patienten mit Parkinson Syndrom. Klin. Wschr. 39:1056, 1961.         [ Links ]

6. BERHEIMER, H. - Distribution of homovanillic acid in the human brain. Nature (London) 204:587, 1964.         [ Links ]

7. BERHEIMER, H.; BIRKMAYER, W. & HORNYKIEWICZ, O. - Homovanillinsaure im Liquor cerebrospinalis: Untersuchungen beim Parkinson-Syondrom und anderen Erkrsnkungen des ZNS. Wien. Klin. Wschr. 78:417, 1966.         [ Links ]

8. BIRKMAYER, W. - Experimented Ergebnisse über die Kombinationsbehandlung des Parkinson syndroms mit L-DOPA und einem Decarboxylasehemmer (Ro 4-4602). Wien. Klin. Wschr. 81:677, 1969.         [ Links ]

9. CARLSSON, A. - The occurrence, distribution and physiological role of catecholamines in the nervous systems. Pharmacol. Rev., 11:490, 1959.         [ Links ]

10. CHARCOT, J. M. - Leçons sur les Maladies dy Système Nerveux faltes à la Salpètrière, ed. Bourncville, A. Delahaye et Lecrosnier, Paris, 1892, págs. 155/158.         [ Links ]

11. DUVOISIN, R. C. - Cholinergic-anticholinergic antagonism in parkinsonism. Arch. Neurol. (Chicago) 17:124, 1967.         [ Links ]

12. EHRINGER, H. & HORNYKIEWICZ, O. - Verteilung von Noradrenalin und dopamin (3-Hydroxytyramin) im Gehirn des Menschen und ihr Verhalten Erkran-kingen des extrapyramidalen Systems. Klin. Wschr. 38:1236, 1960.         [ Links ]

13. FELDBERG, W. & VOGT, M. - Acetylcholine syntesis in different regions of the central nervous system. J. Physiol. 107:372, 1948.         [ Links ]

14. HORNYKIEWICZ, O. - Neurochemistry of parkinsonism. In: Handbook of Neurochemistry, vol. 7, Pathological chemistry of the nervous system, ed. Lajtha, A.. Plenum Press, New York-London, chap. 19:465, 1972,         [ Links ]

15. LLOYD; K. - Neurochemical compensation in Parkinson's desease. In Lakke, J. P. W. F.; Korf, J. & Wesseling, EL, eds. - Parkinson's Disease: Concepts and Prospects. Proceedings of a Symposium held at the University of Gronincen, Excerpta Medica (Amsterdan) 1977. págs. 61/72.         [ Links ]

16. MAWDESLEY, C. - The management of parkinsonism. Practitioner 204:487, 1970.         [ Links ]

17. MCLENNAN, H. - The release of dopamine from the putamen. Experientia 21:725, 1965.         [ Links ]

18. NOVIS, S. A. P. & CAVALCANTI, J. L. S. - Recentes aquisições em terapêutica neurológica: afecções extrapiramidais. In VI Congresso Brasileiro de Neurologia, Rio de Janeiro, julho 1974. Resumos: 79, 1974.         [ Links ]

19. RINNE, U. K.; RIEKKINEN, P.; SONNINEN, V. & LAAKSONEN, H. - Brain acetylcholinesterase in Parkinson's disease. Acta. Neurol. Scand. 49:215, 1973.         [ Links ]

 

 

Trabalho realizado no Instituto de Neurologia Deolindo Couto da UFRJ (Serviço do Prof. Bernardo Couto).
Instituto de Neurologia Deolindo Couto da U.F.R.J. - An. Venceslau Brás 95 - Botafogo - 22290 Rio de Janeiro, RJ.

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