Densidade dos movimentos oculares rápidos durante o sono ativo em recém-nascidos pré-termo

Reimão, Rubens; Lemmi, Helio; Hamlett III, James; Sander, Craig; Zwaag, Roger Vander

doi:10.1590/S0004-282X1986000300001

Resumos

A densidade dos movimentos oculares rápidos (REM) é índice utilizado rotineiramente na polissonografia de adultos para avaliação da atividade fásica durante o sono REM. Analisamos aqui a densidade REM em 28 recém-nascidos de 34 a 39 semanas de idade concepcional (IC). Densidade REM foi medida por dois critérios distintos: a - Densidade REM como relação entre a duração dos movimentos oculares rápidos e a dos períodos REM. Tais índices variavam de 10,6% a 14,1% e foram mais elevados no grupo de 36-37 semanas IC. A densidade do primeiro período REM era mais elevada que a média dos demais; b - Densidade REM como percentagem dos segmentos de 10 s de sono REM nos quais ocorriam movimentos oculares rápidos. Tal critério confirmou os limites estreitos dos índices nessa faixa etária (39,6-44,6%), os quais foram mais elevados no primeiro período REM e no grupo de 36-37 semanas IC Nossos dados sugerem que também nos recém-nascidos pré-termo a densidade REM é uma característica consistente da atividade fásica e seus níveis se mantêm próximos aos da população adulta, apesar da redução ontogenética gradual na duração do sono REM.

Rapid eye movement (REM) density has been helpful as a reliable index of phasic eye movements activity during REM (active) sleep in adults. We evaluated this index in 28 newborns, at 34 to 39 weeks of conceptional age (CA). The 5 hours Polysomnographie recording during sleep included electroencephalogram, electrooculogram, electrocardiogram, pneumogram, nasal thermistor for detecting airflow, and continuous oxygen saturation (tcP02) monitoring. REM density was measured by two distinct criteria: a - REM density as the duration of phasic eye movements in relation to REM periods (REMP). Such index varied from 10.6 to 14.1% and was higher in the 36-37 weeks CA group. b - REM density was calculated as a percentage of 10-second epochs of REM sleep in which phasic eye movements occurred. This criterion confirmed the narrow range of such index in this age bracket (39.9-44.6%), was higher in the first REMP and in the 36-37 weeks CA group. Our data suggest that REM density is a consistent phasic REM sleep feature in preterm newborns with levels close to the adult population, inspite of the gradual decrease of REM sleep duration with age. Higher indices were also found in the first REMP and in the 36-37 weeks CA grou by both methods.

Densidade dos movimentos oculares rápidos durante o sono ativo em recém-nascidos pré-termo

Rapid eye movement density in preterm infanfs active sleep

Rubens Reimão^I; Helio Lemmi^II; James Hamlett III^III; Craig Sander^III; Roger Vander Zwaag^IV

^INeurologista - Trabalho do Department of Neurodiagnostics, Baptist Memorial Hospital, Memphis, Tennessee, E.U.A.

^IIClinical Professor of Neurology, University of Tennessee Center for Health Sciences - Trabalho do Department of Neurodiagnostics, Baptist Memorial Hospital, Memphis, Tennessee, E.U.A.

^IIINeonatologista - Trabalho do Department of Neurodiagnostics, Baptist Memorial Hospital, Memphis, Tennessee, E.U.A.

^IVEstaticista. Bolsa CAPES 3502/82. - Trabalho do Department of Neurodiagnostics, Baptist Memorial Hospital, Memphis, Tennessee, E.U.A.

RESUMO

A densidade dos movimentos oculares rápidos (REM) é índice utilizado rotineiramente na polissonografia de adultos para avaliação da atividade fásica durante o sono REM. Analisamos aqui a densidade REM em 28 recém-nascidos de 34 a 39 semanas de idade concepcional (IC). Densidade REM foi medida por dois critérios distintos: a - Densidade REM como relação entre a duração dos movimentos oculares rápidos e a dos períodos REM. Tais índices variavam de 10,6% a 14,1% e foram mais elevados no grupo de 36-37 semanas IC. A densidade do primeiro período REM era mais elevada que a média dos demais; b - Densidade REM como percentagem dos segmentos de 10 s de sono REM nos quais ocorriam movimentos oculares rápidos. Tal critério confirmou os limites estreitos dos índices nessa faixa etária (39,6-44,6%), os quais foram mais elevados no primeiro período REM e no grupo de 36-37 semanas IC Nossos dados sugerem que também nos recém-nascidos pré-termo a densidade REM é uma característica consistente da atividade fásica e seus níveis se mantêm próximos aos da população adulta, apesar da redução ontogenética gradual na duração do sono REM.

SUMMARY

Rapid eye movement (REM) density has been helpful as a reliable index of phasic eye movements activity during REM (active) sleep in adults. We evaluated this index in 28 newborns, at 34 to 39 weeks of conceptional age (CA). The 5 hours Polysomnographie recording during sleep included electroencephalogram, electrooculogram, electrocardiogram, pneumogram, nasal thermistor for detecting airflow, and continuous oxygen saturation (tcP02) monitoring. REM density was measured by two distinct criteria: a - REM density as the duration of phasic eye movements in relation to REM periods (REMP). Such index varied from 10.6 to 14.1% and was higher in the 36-37 weeks CA group. b - REM density was calculated as a percentage of 10-second epochs of REM sleep in which phasic eye movements occurred. This criterion confirmed the narrow range of such index in this age bracket (39.9-44.6%), was higher in the first REMP and in the 36-37 weeks CA group. Our data suggest that REM density is a consistent phasic REM sleep feature in preterm newborns with levels close to the adult population, inspite of the gradual decrease of REM sleep duration with age. Higher indices were also found in the first REMP and in the 36-37 weeks CA grou by both methods.

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

Sleep Disorders Center, Department of Neurodiagnostics, Baptist Memorial Hospital - 899 Madison Avenue - Memphis, Tennessee, 38146 - USA.

1. ANDERS, T.; EMDE, R. & PARMELEE, A. - A Manual of Standardized Terminology, Techniques and Criteria for Scoring of States of Sleep and Wakefulness in Newborn Infants. Brain Information Service/Brain Research Institute. University of California, Loa Angeles, 1971.
2. ANTONIONI, M.; SOLANO, L.; TORRE, A.; VIOLANI, C.; COSTA, M. & BERTINI, M. - Independence of REM density from other REM sleep parameters before and after REM deprivation. Sleep 4:221, 1981.
3. ASERINSKT, E. - The maximal capacity for sleep: rapid eye movement density as an index of sleep satiety. Biol. Psychiatry 1:147, 1969.
4. ASERINSKT, E. - Rapid eye movement density and pattern in the sleep of normal young adults. Psychophysiology 8:361, 1971.
5. ASERINSKT, E. - Relationship of rapid eye movement density to the prior accumulation of sleep and wakefulness. Psychophysiology 10:545, 1973.
6. AZUMI, K. & JINNAI, S. - Time course of sleep in 20 normal adults (Part II): on REM density and autonomic sleep parameters. Sleep Res. 3:93, 1974.
7. AZUMI, K.; SHIRAKAWA, S. & OGURI, M. - Usefulness of spindle activity and REM density in hypnotic evaluation. Sleep Res. 10:73, 1981.
8. BENOIT, O.; PAROT, S. & GARMA, L. - Evolution during the night of REM sleep in man. Electroencephalogr. clin. Neurophysiol. 36:345, 1974.
9. DEMENT, W.C. & WOLPERT, E. - The relation of eye movements, body motility and external stimuli to dream content. J. exp. Psychol. 55:543, 1958.
10. FOSTER, F.G.; KUPFER, D.J.; COBLE, P. & MCPARTLAND, R.J. - Rapid eye movement sleep density: an objective indicator in severe medical-depressive syndromes. Arch. gen. Psychiatry 33:1119, 1976.
11. HARTMAN, E. & CRAVENS, J. - Long-term psychotropic drug administration: effects on dream content and on REM density. Sleep Res. 3:1119, 1974.
12. HERTZ, G.; SAMPSON, M.G. & BAKER, T.L. - REM density and sleep apnea. Sleep Res. 14:162, 1985.
13. JOHNSON, B.; ROTH, T.; JANSEN, T. & KRAMER, M. - The effects of drugs on REM density. Sleep Res. 6:40, 1977.
14. KING, D.; AKISKAL, H.S.; LEMMI, H.; WILSON, W.; BELLUOMINI, J. & YEREVANIAN, B.I. - REM density in the differential diagnosis of psychiatric from medical-neurologic disorders: a replication. Psychiatry Res. 5:267, 1981.
15. KOBAYASHI, T.; ENDO, S.; STUJI, Y. & SAITOU, S. - REM density and sleep pattern. Sleep Res. 10:34, 1981.
16. KRAMER, M.; SCHARF, M.B.; HULTEEN, W. & ALTER, J. - Effects of alprazolam one, two and three mg on sleep architecture and REM density. Sleep Res. 11:62, 1982.
17. RECHTSCHAFFEN, A. & KALES, A. - A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. Brain Information Service/Brain Research Institute. University of California, Los Angeles, 1968.
18. WARE, J.C. & HARTMANN, E. - L-tryptophan and sleep: effects on REM density. Sleep Res. 10:72, 1981.
19. ZIMMERMAN, J.C.; CZEISLER, CA.; LAXMINARAYAN, S.; KNAUER, R. & WEITZMAN, E.D. - REM density is dissociated from REM sleep timing during free-running sleep periods. Sleep 2:409, 1980.

Datas de Publicação

Publicação nesta coleção
29 Jun 2011
Data do Fascículo
Set 1986

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

[1] 1. ANDERS, T.; EMDE, R. & PARMELEE, A. - A Manual of Standardized Terminology, Techniques and Criteria for Scoring of States of Sleep and Wakefulness in Newborn Infants. Brain Information Service/Brain Research Institute. University of California, Loa Angeles, 1971.

[2] 2. ANTONIONI, M.; SOLANO, L.; TORRE, A.; VIOLANI, C.; COSTA, M. & BERTINI, M. - Independence of REM density from other REM sleep parameters before and after REM deprivation. Sleep 4:221, 1981.

[3] 3. ASERINSKT, E. - The maximal capacity for sleep: rapid eye movement density as an index of sleep satiety. Biol. Psychiatry 1:147, 1969.

[4] 4. ASERINSKT, E. - Rapid eye movement density and pattern in the sleep of normal young adults. Psychophysiology 8:361, 1971.

[5] 5. ASERINSKT, E. - Relationship of rapid eye movement density to the prior accumulation of sleep and wakefulness. Psychophysiology 10:545, 1973.

[6] 6. AZUMI, K. & JINNAI, S. - Time course of sleep in 20 normal adults (Part II): on REM density and autonomic sleep parameters. Sleep Res. 3:93, 1974.

[7] 7. AZUMI, K.; SHIRAKAWA, S. & OGURI, M. - Usefulness of spindle activity and REM density in hypnotic evaluation. Sleep Res. 10:73, 1981.

[8] 8. BENOIT, O.; PAROT, S. & GARMA, L. - Evolution during the night of REM sleep in man. Electroencephalogr. clin. Neurophysiol. 36:345, 1974.

[9] 9. DEMENT, W.C. & WOLPERT, E. - The relation of eye movements, body motility and external stimuli to dream content. J. exp. Psychol. 55:543, 1958.

[10] 10. FOSTER, F.G.; KUPFER, D.J.; COBLE, P. & MCPARTLAND, R.J. - Rapid eye movement sleep density: an objective indicator in severe medical-depressive syndromes. Arch. gen. Psychiatry 33:1119, 1976.

[11] 11. HARTMAN, E. & CRAVENS, J. - Long-term psychotropic drug administration: effects on dream content and on REM density. Sleep Res. 3:1119, 1974.

[12] 12. HERTZ, G.; SAMPSON, M.G. & BAKER, T.L. - REM density and sleep apnea. Sleep Res. 14:162, 1985.

[13] 13. JOHNSON, B.; ROTH, T.; JANSEN, T. & KRAMER, M. - The effects of drugs on REM density. Sleep Res. 6:40, 1977.

[14] 14. KING, D.; AKISKAL, H.S.; LEMMI, H.; WILSON, W.; BELLUOMINI, J. & YEREVANIAN, B.I. - REM density in the differential diagnosis of psychiatric from medical-neurologic disorders: a replication. Psychiatry Res. 5:267, 1981.

[15] 15. KOBAYASHI, T.; ENDO, S.; STUJI, Y. & SAITOU, S. - REM density and sleep pattern. Sleep Res. 10:34, 1981.

[16] 16. KRAMER, M.; SCHARF, M.B.; HULTEEN, W. & ALTER, J. - Effects of alprazolam one, two and three mg on sleep architecture and REM density. Sleep Res. 11:62, 1982.

[17] 17. RECHTSCHAFFEN, A. & KALES, A. - A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. Brain Information Service/Brain Research Institute. University of California, Los Angeles, 1968.

[18] 18. WARE, J.C. & HARTMANN, E. - L-tryptophan and sleep: effects on REM density. Sleep Res. 10:72, 1981.

[19] 19. ZIMMERMAN, J.C.; CZEISLER, CA.; LAXMINARAYAN, S.; KNAUER, R. & WEITZMAN, E.D. - REM density is dissociated from REM sleep timing during free-running sleep periods. Sleep 2:409, 1980.

Brasil

Brasil

Densidade dos movimentos oculares rápidos durante o sono ativo em recém-nascidos pré-termo

Rapid eye movement density in preterm infant's active sleep

Resumos

Datas de Publicação