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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.44 no.3 São Paulo Sept. 1986

http://dx.doi.org/10.1590/S0004-282X1986000300003 

Estudo das manifestações neurológicas em 93 doentes com intoxicação exógena por substancias químicas não medicamentosas

 

Neurologic manifestations in 93 patients with exogenous intoxication by non-medicamentous chemical substances

 

 

S. AgapejevI; I. VassilievII; M. M. F. LimaIII

IDepartamento de Neurologia e Psiquiatria, Faculdade de Medicina (FMB) - Universidade Estadual Paulista, Campus de Botucatu
IIDepartamento de Farmacologia, Instituto Básico de Biologia Médica e Agrícola (IBBMA) - Universidade Estadual Paulista, Campus de Botucatu
IIIAcadêmica, FMB - Universidade Estadual Paulista, Campus de Botucatu

 

 


RESUMO

Foram analisadas as manifestações neurológicas em 93 doentes com suspeita de intoxicação exógena. A detecção das substancias tóxicas foi realizada no sangue, urina e líquido cefalorraqueano. Verificou-se nítido predomínio do comprometimento do sistema nervoso central em relação ao periférico e aparente tropismo de herbicidas e organofosforados para o sistema nervoso central, comparando-se o comportamento dos metais pesados e organoclorados. São analisados os prováveis mecanismos de ação dessas substancias no sistema nervoso e são apresentados os sinais e/ou sintomas que foram observados.


SUMMARY

Ninety-three patients with neurological manifestations and suspected exogenous intoxication were analysed. The detection of toxic substances was performed in the blood, urine and cerebrospinal fluid. There was clear predominance of the central nervous system impairment than the peripheric, and an apparent tropism of herbicides and organophosphates to the central nervous system compared with the peripheral nervous system, and considering the manifestations caused by carbamates and organochlorines. The authors analyse some probable action mechanism of these substances in the nervous system, and show the most frequently neurological signs and symptoms found.


 

 

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Departamento de Neurologia e Psiquiatria - Faculdade de Medicina de Botucatu, UNESP - 18600 - Botucatu, SP - Brasil.

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