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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.46 no.3 São Paulo Sept. 1988

http://dx.doi.org/10.1590/S0004-282X1988000300003 

Estudo dos linfócitos circulantes por anticorpos monoclonais na miastenia grave

 

Evaluation of circulant lymphocytes in myasthenia gravis by monoclonal antibodies

 

 

Paulo E. MarchioriI; Alberto J. DuarteII; M. Izabel A. M. BirolliIII; Cristina A. FigueiredoIII; Milberto ScaffIV; J. Lamartine de AssisIV

IMédico Assistente da DNC - Disciplina de Neurologia Clínica (DNC) do Departamento de Neurologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Laboratório de Imunogenética e Transplante Experimental (LIM 73) do Instituto dos Laboratórios de Investigação Médica (LIM) do Hospital das Clínicas (HC) da FMUSP
IIProfessor Livre Docente da Disciplina de Alergia e Imunologia da FMUSP - Disciplina de Neurologia Clínica (DNC) do Departamento de Neurologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Laboratório de Imunogenética e Transplante Experimental (LIM 73) do Instituto dos Laboratórios de Investigação Médica (LIM) do Hospital das Clínicas (HC) da FMUSP
IIIBiologista do LIM 73 - Disciplina de Neurologia Clínica (DNC) do Departamento de Neurologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Laboratório de Imunogenética e Transplante Experimental (LIM 73) do Instituto dos Laboratórios de Investigação Médica (LIM) do Hospital das Clínicas (HC) da FMUSP
IVProfessor Adjunto da DNC - Disciplina de Neurologia Clínica (DNC) do Departamento de Neurologia da Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Laboratório de Imunogenética e Transplante Experimental (LIM 73) do Instituto dos Laboratórios de Investigação Médica (LIM) do Hospital das Clínicas (HC) da FMUSP

 

 


RESUMO

Os autores avaliam os linfócitos T (CD3, CD4, CD8, CD4/8) por anticorpos monoclonais e rosácea em 20 pacientes e linfócitos B por Fab' por imunofluorescência em 9 pacientes com miastenia grave. Observam elevação significante na população de linfócito B e redução nos linfócitos T totais CD3+ por rosáceas. Não foram observadas modificações nas subpopulações celulares com timectomia e corticosteróides.


SUMMARY

A significant decline of CD3 cell detected by rosettes and a significant increased of B cell populations were observed. The total CD3+, helper CD4+ and suppressor CD8+ T-cell subsets showed no significant variation em relation to sex, age thymectomy and corticotherapy by monoclonal antibodies.


 

 

Texto completo disponível apenas em PDF.

Full text available only in PDF format.

 

 

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