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Arquivos de Neuro-Psiquiatria

Print version ISSN 0004-282X

Arq. Neuro-Psiquiatr. vol.46 no.3 São Paulo Sept. 1988

http://dx.doi.org/10.1590/S0004-282X1988000300006 

Correlation between specific histological and electromyographic findings in neuromuscular disorders

 

Correlação entre anormalidades específicas da histologia e da eletromiografia em doenças neuromusculares

 

 

Lineu Cesar WerneckI; José Geraldo Camargo LimaII; Henrique KoehlerIII

IAdjunct Professor (Neurology) - Division of Neurology, Internal Medicine Department and Division of Biometry and Statistics, Agrarial Sciences Department, Universidade Federal do Paraná, Curitiba; Neurology Department, Escola Paulista de Medicina, São Paulo
IIFull Professor (Neurology) - Division of Neurology, Internal Medicine Department and Division of Biometry and Statistics, Agrarial Sciences Department, Universidade Federal do Paraná, Curitiba; Neurology Department, Escola Paulista de Medicina, São Paulo
IIIAssistant Professor (Agrarial Sciences) - Division of Neurology, Internal Medicine Department and Division of Biometry and Statistics, Agrarial Sciences Department, Universidade Federal do Paraná, Curitiba; Neurology Department, Escola Paulista de Medicina, São Paulo

 

 


SUMMARY

An attempt was made to find a correlation between specific electromyography (EMG) abnormalities with histological findings in muscle biopsies (MB) in 100 patients with neuromuscular disorders. Quantified EMG and MB with histochemistry was made in the same muscle, but on the opposite side, within a period of 3 weeks. The isolated findings of EMG and MB were analysed with a computer through a chi-square test. A statistical relation (p<0.01) was found between the isolated findings of MB and EMG in only 6.99% (39 in 558 attempts) of the abnormalities expected to occur in myopathy and denervation. Also was found 2.51% (14 in 558 attempts) of inconsistences with the current literature.


RESUMO

Estudo de 100 pacientes com doenças neuromusculares, procurando verificar a correlação entre, anormalidades específicas da eletromiografia (EMG) com alterações histológicas da biópsia muscular (BM). Foi realizada EMG quantificada e BM com histoquímica do mesmo músculo mas em lados opostos, sendo os procedimentos realizados no máximo dentro do período de três semanas. As alterações isoladas da EMG e da BM foram analisadas pelo teste do chi-quadrado e, auxílio de computador. Relação estatística adequada (p<0.01) foi encontrada entre os dados isolados da BM e EMG em somente 6,99% (39 em 558 testes) das anormalidades esperadas em miopatias e desinervações. Também foram encontradas 2,51% (14 em 558 testes) de inconsistências com os dados publicados atualmente, com referência à patogênese das alterações. Nos comentários é feita revisão da patogenia das principais alterações histológicas e eletromiográficas que podem confundir achados de miopatia com desinervações. Concluindo, os autores acreditam que os dados incompatíveis e a falta de relação da maioria dos dados pode ser decorrente do método utilizado, utilização inadequada de um dos métodos, tentativas de obter relações que os métodos não permitem ou a que os conceitos entre os achados eletromiográficos e histológicos devem ser revistos.


 

 

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Divisão de Doenças Neuromusculares, Especialidade de Neurologia, Departamento de Clínica Médica - Hospital de Clínicas, Universidade Federal do Paraná - Rua General Carneiro 181 - 80000 Curitiba PR - Brasil

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